Meriana e thibelang COX e ka 'na ea se ke ea e-ba ntho e ntle
Bothata le ho ruruha, tlhaloso e ka sehloohong ea batho ba bangata ka nako e itseng bophelong ba bona le maemo a tloaelehileng a letsatsi le leng le le leng ho batho ba bangata ba tšoeroeng ke ramatiki, haholo-holo e bakoa ke cyclooxygenase kapa COX ka nakoana.
COX ke enzyme e etsang li-prostano- prostaglandins , prostacyclins, le thromboxanes-e leng tsohle tse ikarabellang bakeng sa karabo ea ho ruruha.
Ho hlahisa hore COX ha e mpe kaofela, ho hlokahala le bakeng sa mekhoa e tloaelehileng ea lik'hamera.
Lithethefatsi tse reretsoeng ho thibela COX ho fokotsa ho ruruha, li bonahala eka ke khopolo e ntle, empa ka ho thibela COX, ho na le bothata bo fokolang.
COX-1 le COX-2
Lilemong tsa bo-1990, ho fumanoe hore ho na le mefuta e 'meli ea COX-1 le COX-2 ea enzyme. Sepheo sa bobeli ke se lakatsehang haholo ho tse peli. COX-1 e tsejoa hore e teng liphatsong tse ngata. Ka pampiri ea meno, COX-1 e boloka lesela le tloaelehileng la mpa mme e sireletsa mpa ho tswa ho lero la lijo. Enzyme e boetse e ameha mosebetsing oa liphio le platelet. COX-2 e fumanoa haholo libakeng tsa ho ruruha.
Ka bobeli COX-1 le COX-2 li ka baka bohloko le ho ruruha, empa kaha COX-1 ke enzyme e molemo joalo, ho sebelisa lithethefatsi ho thibela ho ka 'na ha se ke ha e-ba le maikutlo a joalo.
NSAID e thibela COX
Lithethefatsi tse sa thibeleng ho ruruha (NSAID), tse atisang ho behoa ho phekola ramatiki, li sebetsa ka ho thibela prostaglandins. Masiana a tloaelehileng, joaloka ibuprofen le naproxen, a ka baka mathata a bokhachane ho akarelletsa le liso .
Li-NSAID tsena ha li tlohele, ho bolelang hore li thibela ka bobeli COX-1 le COX-2. Ho thibela COX-2 ka li-NSAID tsa setso ho molemo bakeng sa liphello tsa eona tse khahlanong le ho ruruha, empa ho nyahama ke thibelo ea COX-1 e ka lebisa litla-morao tse kang lisosa, nako ea mali a nako e telele le mathata a liphio.
COX-2 NSAID tse khethiloeng
Ho elella bofelong ba lilemo tsa bo-1990, lik'hamphani tsa lithethefatsi li ile tsa hlahisa meriana e 'maloa e neng e lebisitse ho COX-2 feela, li-NSAID tsena e ne e le Celebrex, Vioxx le Bextra.
Har'a tsona, Celebrex ke eona feela lithethefatsi tse setseng 'marakeng United States' me e na le lebokose le letšo le lemosang hore le na le kotsi ea lefu la pelo le ho otloa ke lefu.
Ho tloha ka ho tlosoa ha Vioxx ka 2004, US Administration le Drug Administration e ile ea hlahloba sehlopha sohle sa lithethefatsi, ho akarelletsa le li-NSAID tsohle le li-inhibitor tsa COX-2 tse neng li rekisoa ka holimo-limo kapa ka lengolo la ngaka, 'me li kenyelelitsoe litemoso tse bobebe ho litaelo .
Tse ling tse peli tsa COX-2 inhibitors, Arcoxia le Prexige, tse sebelisoang linaheng tse ling, li hanngoe ke FDA. Prexige e ile ea tlosoa 'marakeng Australia le Canada ka lebaka la mathata a sebetsang le sebete.
Bafuputsi ba bang ba lumela hore ka mor'a hore ba fumane likarolo tse tlaase tsa COX-2 linthong tse ling tseo e seng tsa maiketsetso, COX-2 e ka ba le karolo mesebetsing e meng e tloaelehileng ea 'mele ntle le ho ruruha. Bafuputsi ba UK ba hlokometse hore COX-2 e ka sireletsa khahlanong le ho fokotsa matla a ho bolaoa ha methapolasetiki, lentsoe la bongaka bakeng sa ho thatafala ha arter, ho fokotsa le ho koala.
Le hoja li-NSAID le li-inhibitor tsa COX-2 li nkoa e le likhetho tse kholo tsa phekolo bakeng sa bakuli ba ramatiki , melemo le likotsi li lokela ho nahanngoa bakeng sa mokuli ka mong. Kotsi ea bophelo le mofuta o motle oa NSAID o lokelang ho o sebelisa o lokela ho hlahlojoa.
> Mohloli
> Arthritis Foundation. NSAIDs.
> Bathon, Joan M. Puisano ea Li-COX-2 tse thibelang likokoana-hloko. Johns Hopkins Setsi sa Ramatiki.
> Kirkby N, Lundberg M, Wright W, Warner T, Paul-Clark M, Mitchell, J. COX-2 O sireletsa khahlanong le lefu la tšoaetso ea mali ka botšepehi ea Local Vascular Prostacyclin: Ho khetholla COX-2 Associated Pathways Implicate Rgl1 le Lymphocyte Networks. PLOS One. La 2 June, 2014.