Bohloko ba Matšoao a Matšoao
Prostaglandin ke li-hormone tse nang le tšusumetso e kholo holim'a lits'ebetso tsa bohlokoa tsa 'mele meleng oa hau. Li na le liphello tse ntle le tse mpe bophelong ba hao. Ka mantsoe a mang, prostaglandin e tsamaisa homeostasis, empa e boetse e khothalletsa mekhoa ea mafu.
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Lintho tsena tse khutšoanyane li entsoe ka mafura a mafura, 'me li phetha karolo mesebetsing e mengata ea motheo.
Tse ling tsa mesebetsi ena li kenyelletsa, ka mohlala, vasodilation le vasoconstriction. Vasodilation le vasoconstriction ke, ka ho latellana, mokhoa o itekanetseng oa tšebetso ea mali ea ho bula le ho koala. Tse ling li kenyelletsa li-bronchoconstriction, e leng khohlano ea litsela tsa moea, ho pata mali, ho thibela mali, feberu le tlhokomelo ea lik'hemik'hale tse kang malapa a hao a mala.
Hammoho le lintho tse lethathamong le ka holimo, prostaglandin e ama maemo a bohloko mme e laola ho ruruha, mekhoa e 'meli ea' mele e amang motho e mong le e mong ea sebetsanang le bothata ba molala kapa mokokotlo.
Ho latela mohlophisi oa 2003 ka Nature Structural Biology , ho na le mefuta e ka bang 24 e fapaneng ea prostaglandin.
Meriana eo Prostaglandins e se Lebelang
Hobane prostaglandin e phetha karolo ea bohlokoa ho qaleng le ho tsoela pele ho ruruha, lithethefatsi tse ngata li 'nile tsa ntlafatsoa ho feta lilemo ho loantša ketso ea tsona. Lithethefatsi tsena li nkoa li sebetsa hantle ebile li sa theko e tlaase, 'me batho ba pota-potileng lefatše le ho theosa le lilemo ba' nile ba retelehela ho bona bakeng sa liphallelo.
Mehleng ea boholo-holo, makhapetla a marulelo a ne a sebelisetsoa ho fokotsa bohloko le ho fokotsa feberu, 'me matsatsing ana ba bangata ba litlama tsa hohle ba phehella semela sena ho bareki ba bona ba feberu. Lilemong tsa bo-1820, motsoako o sebetsang oa makhapetla a meroho o ne o ikemiselitse ho ba salicylic acid. Empa ha bakuli ba e-na le mathata a matla a mala, ho akarelletsa letšollo le ho hlatsa, ka lebaka la ho nka salicylic acid, acetylsalicylic acid e qalile ho sebelisoa sebakeng sa eona.
Lilemong tsa bo-1890, acetylsalicylic acid e qalehile 'marakeng e le aspirin ke k'hamphani e tsejoang hona joale le Bayer.
COX Inhibitor Lithethefatsi
Lilemong tsa bo-1960 sehlopha sa lithethefatsi se bitsoang phenylolkanoic acid se fumanoe se fokotsa ho ruruha le bohloko. Li-acid tsena li etsa joalo ka ho thibela cyclooxygenase, kapa COX. (COX enzymes e atisa ho nka bohato pele ho nako molokong oa prostaglandins.) "Li-Painkillers le prostaglandins" sehlooho se re li-enzyme tse tharo tsa COX li fumanoe: COX 1 e sireletsang pampitšana ea hau ea GI, COX 2, e nang le karolo ho ho ruruha, feberu , le bohloko le COX 3 e fumanoang haholo-holo bokong. Li-COX inhibitors (tseo hona joale li leng 'marakeng) bakeng sa bohloko le ho ruruha-mofuta o nkiloeng ke batho ba nang le molala kapa bohloko ba morao-kenyeletsa aspirin le ibuprofen ( Advil ). Aspirin le Advil li thibela ka bobeli COX 1 le li-enzyme tsa COX 2. Litholoana tse tsebahalang tsa meriana ena ke liso tsa mali le mali a tsoang ka lesela la mpa.
Advil hape o tla le kotsi ea lefu la pelo le ho otloa ke lefu, ka bomalimabe.
Ha e le hantle, ntle le aspirin, lithethefatsi tsohle tse sa thibeleng ho ruruha (NSAID) li tla le temoso ea FDA "lebokose le batsho" hore ho noa meriana ho phahamisa kotsi ea lefu la pelo.
U ka 'na ua hopola Vioxx le Bextra , bao pele ba tšepisitseng bohloko ba ho ntša bohloko ba ileng ba tlosoa' marakeng ka 2004. Liketso tsa lithethefatsi tsena e ne e le ho thibela feela enzyme ea COX 2; ka hona, ba ne ba boetse ba tsejoa e le COX 2 inhibitors. Melemo ea bona e bile hore litla-morao tse amanang le mpa li fetile; bothata e ne e le hore ka nako e tšoanang lithethefatsi tsena li ne li thabela maemo a thibelang marang-rang marakeng, ho ile ha etsoa qeto ea hore COX-2 inhibitors e ekelitse kotsi ea ho hlaseloa ke pelo haholo le ho bolaea pelo.
Ka September 2004, Merck ka boithaopo o ile a hula Vioxx ka 'marakeng. Ka April 2005, FDA e laetse Pfizer moetsi oa lithethefatsi hore a hule Bextra 'marakeng empa a lumella Celebrex (Celecoxib) hore e lule, moo e etsoang le kajeno.
Lentsoe ho
Ho tsebahala hore ho ruruha ke motso oa maloetse a mangata a mehleng ea kajeno, ho akarelletsa bohloko bo sa foleng. Hape ho tsebahala hore ho noa meriana ho sebetsana le mathata a amanang le ho ruruha ho ka 'na ha e-ba le litla-morao, tse ling tsa tsona e ka ba tse tebileng haholo.
Ho finyella seo, bafani ba bangata ba bophelo bo botle, bakuli le meriana ea meriana ea tlhaho ba buella kapa ba latela lijo tse khahlanong le ho ruruha . Sehlooho se hatisitsoeng Harvard Women's Health Watch se tlalehile hore lipatlisiso tse ngata li bontšitse lijo li ka ba le phello e khahlanong le ho ruruha.
Ho tseba hore na ke eng e ka thusang ho theha motheo oa lijo tse ka u thusang ho loantša liphello tsa ho ruruha.
Batho ba bang ba boetse ba nka litlama tse khahlanong le ho ruruha kapa li-supplement , tse kang marang-rang a marulelo, a neng a tšohloa ka holimo.
> Mehloli:
> Mohlophisi. Li-Painkillers le prostaglandins. Boemo ba Bioloji ea Tlhaho. 2003
> Harvard Women's Health Watch. Lijo tse loantšang ho ruruha ka August 2017.
> Ricciotti, E., PhD, FitzGerald, Garret A., MD. Prostaglandins le Inflammation. Arterioscler Thromb Vasc Biol. May 2011.