Meriana ea Lithethefatsi e fana ka lits'ebeletso tse phahameng tsa pheko bakeng sa likokoana-hloko tsa 1 le tse 4 tsa Genotype
Kemiso
Sefate (elbasvir / grazoprevir) ke tekanyo e tsitsitseng e kopantseng lithethefatsi tse sebelisoang ho phekola tšoaetso e sa foleng ea hepatitis C (HCV) . Lithethefatsi tse peli tse kenyang mosebetsi oa Zepatier (elbasvir, grazoprevir) ka ho thibela ka bobeli protheine (NS5a) le enzyme (NS3 / 4a protease) e bohlokoa bakeng sa ho pheta-pheta ha vaerase.
Zepatier e ile ea amoheloa ka la 28 January, 2016 ke US Food and Drug Administration (FDA) e sebelisoang ho batho ba baholo lilemong tse 18 kapa ho feta ka tšoaetso ea HCV ea 1 kapa ea 4 , ho kenyeletsa le ba nang le boloetse ba boloetse.
E amoheloa hore e sebelisoe ka bobeli bo sa sebelisoang (kalafo-naïve) kapa bakuli ba neng ba kile ba phekoloa (ba nang le phihlelo), ho itšetlehile ka mofuta oa HCV le boemo ba kalafo.
E sebetsa hantle
Ho boleloa hore Zepatier e na le litefello tse ikhethang tsa phekolo ea liteko tsa batho ba bobeli. Pheko ea HCV e hlalosoa e le ho boloka kokoana-hloko e sa bonahaleng ka libeke tse 24 ka mor'a phekolo ea phekolo (eo hape e tsejoang e le phetoho ea virologic, kapa SVR ).
Litefiso tsa SVR ka kakaretso li fapane ho tloha ho 94% ho isa ho 97% ho bakuli ba nang le tšoaetso ea mofuta oa HCV, ha ba bakuli ba nang le tšoaetso ea 4 ea genotype ba tlalehiloe hore ba na le likhau tsa SVR tsa 97% ho 100%.
Tekanyo
Letlapa le le leng (50mg / 100mg) le nkiloe letsatsi kapa leng le le leng ka lijo kapa ntle le lijo. Matlapa a sefate a sephara, a mebala-bala le a koahetsoeng ka filimi, a na le "770" e khabisitsoeng ka lehlakoreng le leng.
Ho hlalosa Litlhahiso
Sefapati e behiloe ka ntle kapa ntle le ribavirin bakeng sa tšoaetso ea genotypes 1 kapa 4. Ho fapana le mekhoa ea pele ea phekolo ea HCV, peginterferon (sethethefatsi se amanang le hangata se ke keng sa qojoa) ha se hlokehe.
Pele ho qala ts'oaetso, liteko tsa liphatsa tsa lefutso li ka etsoa ho fumana hore na o na le mofuta oa kokoana-hloko e sa hanyetsanang le karolo ea elbasvir ea Zepatier (e tsejoang e le mokhoa oa ho hanyetsa oa NS5a o amanang le polymorphism).
Nako ea lisebelisoa tsa meriana ho tloha libeke tse 12 ho isa ho 16, ho itšetlehile ka mofuta oa HCV le boemo ba kalafo.
| Genotype | Sebaka sa phekolo | E nkiloe le ribavirin? | Nako |
| Genotype 1a | phekolo-naïve ntle le elbasvir-resistant kokoana-hloko | Che | Libeke tse 12 |
| kalafo-naïve e nang le elbasvir-resistant kokoana-hloko | e | Libeke tse 16 | |
| e neng e tšoaroa ka nako e fetileng le ribavirin peginterferon ntle le kokoana-hloko e mamellang elbasvir | Che | Libeke tse 12 | |
| e neng e tšoaroa ka nako e fetileng le ribavirin peginterferon le kokoana-hloko e mamellang elbasvir | e | Libeke tse 16 | |
| e neng e tšoaroa ka nako e fetileng le ribavirin peginterferon + HCV protease inhibitor | e | Libeke tse 12 | |
| Genotype 1b | phekolo-naïve | Che | Libeke tse 12 |
| e neng e tšoaroa ka nako e fetileng le ribavirin peginterferon | Che | Libeke tse 12 | |
| e neng e tšoaroa ka nako e fetileng le ribavirin peginterferon + HCV protease inhibitor * | e | Libeke tse 12 | |
| Genotype 4 | phekolo-naïve | Che | Libeke tse 12 |
| e neng e tšoaroa ka nako e fetileng le ribavirin peginterferon | e | Libeke tse 16 |
* - Olysio (simeprevir), Victrelis (boceprevir), Incivek (telaprevir)
Liphello tse Tloaelehileng
Litla-morao tse tloaelehileng tse amanang le ts'ebeliso ea likhahla (tse fetang bakuli ba fetang 5%) ke:
- Mokhathala
- Hlooho ea hlooho
- Nausea
Ha e sebelisoa le ribavirin, litlaleho tse atisang ho tlalehoa kalafo (tse fetang bakuli ba fetang 5%) li kenyelletsa:
- Hlooho ea hlooho
- Mokhathala
- Anemia
- Nausea
- Ho tsuba
- Boitšoaro
- Phefumoloho e khutšoanyane
- Ho tsieleha
- Mahlaba a mesifa
- Ho fokotsa takatso ea lijo
- Ho tsuba
- Ho halefa
- Rash
Litšebelisano le lithethefatsi
Meriana e latelang ha ea lokela ho sebelisoa ha e nka Zepatier ha e ntse e ka baka likamano tse kholo tsa lithethefatsi:
- Likokoana-hloko: nafcillin
- Anticonvulsives: Dilantin (phenytoin), Tegretol (carbamazepine)
- Li-antifungals: Li-tablet tsa Nizoral (ketoconazole)
- Lithethefatsi tse nang le chefo e matla: Tracleer (bosentan)
- Lihlahisoa tsa lihlahisoa: Litlhapi tsa St. John's
- Meriana ea mafu a meriana ea kokoana-hloko ea HIV: Aptivus (tipranavir), Genvoya (elvitegravir, cobicistat, emtricitabine, tenofovir alafenamide), Intelence (etravirine), Invirase (saquinavir), Kaletra (lopinavir, ritonavir), Prezista (darunavir), Reyataz (atazanvir) elvitegravir, cobicistat, emtricitabine, mokokotlo oa tenofovir), Sustiva (efavirenz),
- Lithethefatsi tsa immunosuppressant tse sebelisetsoang ho thibela ho tlosoa ha setho: cyclosporine
- Meriana ea Rifampin e sebelisoang kalafo ea lefuba: Mycobutin, Priftin, Rifater, Rifamate, Rimactane, Rifadin
Litlhahlobo tsa Kalafo
Ho 'nile ha tlalehoa lipatlisisong tsa bongaka hore 1% ea bakuli ba Zepatier ba hlahisitse matla a matla a likokoana-hloko tsa sebete tse bontšang chefo ea sebete, ka kakaretso kapa ka mor'a beke ea borobeli ea phekolo. Ka hona, liteko tsa mali tse amanang le sebete li lokela ho etsoa pele ho qalo ea phekolo le kamehla nakong ea phekolo ea HCV.
Mofuta oa likhahla ha oa lokela ho ngolloa ho bakuli ba nang le bothata bo matla ba sebete.
Tšebeliso ea ribavirin e hanyetsanoa nakong ea bokhachane 'me ha ea lokela ho behoa e le ka Zepatier kapa kalafo leha e le efe ea hepatitis C. Bakuli ba nang le phekolo ea basebetsi ba ribavirin ba lokela ho eletsoa ho qoba bokhachane le ho sebelisa bonyane mekhoa e 'meli e seng ea hormone ea thibelo ea bokhachane nakong ea phekolo le likhoeli tse tšeletseng ka mor'a phekolo ea phekolo.
Mohloli:
US Administration of Drug and Drug Administration (FDA). "FDA e amohela Sepatier bakeng sa phekolo ea lefuba le sa foleng la lefu la sebete la 1 le la 4." Silver Spring, Maryland; khatiso ea khatiso e fanoeng ka la 28 January, 2016.
Khotsofatsa. "Sekoti - Lintlha-khōlō Tsa ho Hlalosa Boitsebiso." Kenilworth, New Jersey; e fihlile ka la 29 January, 2016.