Ho Hasana ha Sefuba sa Hepatitis C ka potlako Likokoana-hloko Litlaleho tsa ho Fetoha ha Liphatsa Tsa Lefutso
Hona joale ho na le mefuta e 11 e fapaneng ea liphatsa tsa lefutso (genotypes) ea kokoana-hloko ea hepatitis C (HCV) lefatšeng, le hoja ho ata ho hoholo ho bonoa ka li-genotypes 1 ho ea ho 7. Ho phaella ho sena, genotype ka 'ngoe e ka senyeha ka hare ho li-subtypes tse itseng, li aroloa ka lipalo (mohlala, gencope ea HCV 1a kapa 1b).
Ho nka liphatsa tsa lefutso ho nkoa e le tsa bohlokoa kaha ho thusa lingaka hore li tsebe hore na ke lithethefatsi life tse tla sebetsa ka katleho bakeng sa kokoana-hloko ea hao (kapa likokoana-hloko haeba u na le tšoaetso ea genotype e fetang e le 'ngoe).
Tshebetso ea boitsebiso ha e hloke letho ho feta teko ea mali feela, eo mohlala oa eona o hlahlojoang ho sebelisa theknoloji e tsejoang e le teko ea polymerase chain reaction (PCR) .
Genotype 1
Genotype 1 ke mofuta o tloaelehileng ka ho fetisisa oa HCV ho Amerika Leboea le Europe 'me litlaleho tsa likarolo tse ka bang 80 lekholong tsa tšoaetso ho tsoa ho US Genotype 1 likooa li nkoa e le tse ling tse thata ka ho fetisisa ho li phekola, le hoja likokoana-hloko tse ncha tse sebetsang ka ho toba (DAAs) li fumana phekolo e phahameng litekanyetso tse peli tse sa tsoa phekoloa le bakuli ba neng ba tšoeroe pele Karolo ea 1 ea HCV e ka fetisetsoa ho ea ka karoloana 1a, 1b, le 1c.
Genotype 2
Genotype 2 ke karolo ea bobeli e tloaelehileng ea genotype ea HCV US, e ikarabella bakeng sa hoo e ka bang 10% ea tšoaetso eohle. Pele ho etsoa li-DAAs, e ne e le e 'ngoe ea liphatsa tsa lefutso tse sebelisoang habonolo, le bakuli ba nang le menyetla ea 80% ea ho fumana pheko ea kokoana-hloko ea HIV (SVR) e ts'oanang le pheko. Kajeno, palo eo e haufi le bakuli ba bangata ba neng ba kile ba tšoaroa pele ho karolo ea 90% 'me e ka ba 99% ho bakuli ba sa tsoa phekoloa.
Genotype 2 e boetse e na le likarolo tse tharo tse ka sehloohong: 2a, 2b, le 2c.
Genotype 3
Genotype 3 e atile haholo Asia Boroa-bochabela 'me e arolelitsoe ka ho sa feleng ho pholletsa le Australia, India le likarolo tse ling tsa Bochabela bo Hare. Ho hakanngoa hore hoo e ka bang 6% ea Maamerika a na le li-genotype 3 tsa HCV, tse ka theohelang likarolo tse peli tse ka sehloohong: 3a le 3b.
Genotype 4
Genotype 4 e atile haholo Afrika, Bochabela bo Hare le linaheng tse 'maloa tsa Europe bochabela. Egepeta e na le palo e phahameng haholo ea batho ba tšoaelitsoeng ke genotype 4, hammoho le HCV e kholo ka ho fetisisa lefatšeng. Palo e phahameng ea tšoaetso ea HCV litlalehong tsena tsa libaka, karolo e khōlō, bakeng sa likokoana-hloko tse fapaneng tsa liphatsa tsa lefutso, tse kenyeletsang subtypes 4a, 4b, 4c, 4d le 4e.
Genotype 5
Genotype 5 e atisa ho bonoa karolong e ka boroa ea Afrika 'me e nkoa e na le phapang e nyenyane ea liphatsa tsa lefutso le karolo e le' ngoe e ka sehloohong: 5a.
Genotype 6
Genotype 5 e tloaelehile karolong e ka boroa ea Chaena, Hong Kong, le linaheng tse ling tsa Asia Boroa-bochabela. Joaloka genotype 5, ho na le karolo e le 'ngoe e ka sehloohong: 6a.
Genotype 7
Genotype 7 e ile ea kenngoa boitsebisong ba sechaba ka 2014 'me hajoale e fumanoe Thailand le Democratic Republic of Congo. E na le karolo e le 'ngoe e ka sehloohong: 7a.
Ho phaella moo, li-genotypes 9, 10 le 11 li 'nile tsa khetholloa, le hoja tšoaetso e' nile ea e-ba e thōko ka hare ho Vietnam le likarolo tsa Indonesia.
HCV Treatment ea Genotype
Ha ho e-ba le likokoana-hloko tse sebetsang ka ho toba, bakuli ba na le mefuta e mengata ea phekolo ea HCV. Hona joale, Tsamaiso ea Lijo le Meriana ea United States e amohetse li-DAA tse latelang hore li sebelisoe ho bakuli ba li-genotype tsa HCV 1-4 le 6:
- Daklinza (daclatasvir) : HCV genotype 3
- Harvoni (sofusbuvir + ledipasvir) : genotype ea HCV 1
- Sovaldi (sofusbuvir) : liphatsa tsa lefutso tsa HCV 1, 2, 3 le 4
- Technivie (ombitasvir + paritaprevir + ritonavir) : HCV genotype 4
- Viekira Pak (ombitasvir + paritaprevir + ritonavir e kopantsoe le dasabuvir) : HCV genotype 1
- Olysio (simeprevir) : genotype ea HCV 1
- Zepatier (grazoprevir + elbasvir): liphatsa tsa lefutso tsa HCV 1, 4 le 6
Lisebelisoa:
Rockstruh, J. "Kakaretso e tsoang ho EASL 2015 bakeng sa Hepatitis C Kaofela ha molomo oa HCV DAA phekolo ea tsela ea ho ntlafatsa: ho ntse ho hongata hoo u ka ithutang." Seboka sa bo50 sa Mokhatlo oa Europe oa Thuto ea sebete (EASL). La 22-26 April, 2015; Vienna, Austria.
Lihlopha tsa National Diseases Clevelhouse Information. "Chronic Chronic Hepatitis C: Tsamaiso ea Tsamaiso ea Mafu."
Lefapha la United States la Bo-Veterans Affairs. "Hepatitis C Genotype."