Botenya bo 'nile ba amahanngoa le maloetse a mangata, ho akarelletsa le kankere , lefu la pelo le lefu la tsoekere, har'a ba bang. Hona joale bafuputsi ba se amahanya le lefu la Alzheimer.
Middle Age le Alzheimer's
Bafuputsi ba fumane ka ho toba hore botenya bo lilemong tsa bohareng, kapa bohareng ba lilemo, bo bolela esale pele hore lefu la Alzheimer le qala ho ba teng-le boima bo bongata ba lefu (ho bolelang hore lefu lena le tla ba matla haholo ha le otla).
Ha ho hlahlojoa Thuto ea Botsofali ea Longitudinal ea Baltimore, bafuputsi ba ile ba sheba kamano pakeng tsa lipalo tsa boima ba 'mele (BMI) le nako ea ho qala ha lefu la Alzheimer hammoho le ho teba ha lefu lena. Bangoli ba thuto ba fumane hore BMI e holimo lilemong tse bohareng (lilemo tse 50) e amahanngoa le lefu la pele la lefu la Alzheimer hammoho le mehato e phahameng ea maloetse.
Bafuputsi ba fumane hore ho ne ho e-na le likheo tse ngata tse nang le li-amyloid (ho hlalosang lefu la Alzheimer) bokong ba bakuli ba nang le bokooa bo phahameng ba BMI, ha bapisoa le ba nang le bophelo bo botle ba BMI ba le lilemo li 50. Sena se bontša mofuta o matla haholo oa lefu lena .
Bafuputsi ba ile ba fihlela qeto ea hore BMI e phetseng hantle nakong ea bo-midlife e ka 'na ea lieha ho qala ha lefu la Alzheimer. Sena se khothatsa, hobane se bolela hore ho etsa hore BMI e be le boemo bo botle nakong ea midlife e ka thibela ho qala ha Alzheimer's. 'Me mesebetsi e mengata e phetseng hantle e lahleheloang ke boima bo feteletseng le ho boloka boima bo botle, joaloka ho ja ka tsela e leka-lekaneng le ho ikoetlisa kamehla, ke lisosa tse bolokang boko bo phetseng hantle le ho thusa ho thibela' meleng oa 'mele.
Botenya le Dementia
Liphuputso tsa khale li 'nile tsa bontša hore botenya bo amana le' dementia '' me ha BMI e ntse e phahama, ho joalo le ka tekanyo ea kotsi. Phuputsong e 'ngoe e tšoanang le e ka holimo, empa e khannoa karolong e ka bochabela ea Finland, bafuputsi ba ile ba latela bakuli ka lilemo tse 26, ba lekanya ba bona ba lilemo li 50 ka nako e lekaneng le hamorao, ka karolelano ea lilemo tse 71. Bafuputsi ba hlokometse hore na bakuli ba ile ba e-ba le bothata ba 'dementia' hamorao bophelong, 'me ba fumana hore, hape, bohareng ba midlife BMI e ne e amahanngoa le kotsi e kholo ea lefu la dementia le lefu la Alzheimer.
Bafuputsi ba ile ba etsa qeto ea hore "Boima bo fetang boima ba 'mele le botenya bo pakeng tsa bo-'mè le bona bo eketsa kotsi ea lefu la dementia [le lefu la Alzheimer]."
Ba bang ba fumane hore lefu la tsoekere, e leng boloetse bo amanang le botenya, le ka lebisa ho dementia ea pele ho moo. Kahoo ho na le mabaka a mangata a ho lebisa tlhokomelo ho lahleheloa ke boima bo feteletseng ka tsela e phetseng hantle.
Tlosa Boima ba Boima Ho Fumana Bohareng ba Boholo
Bopaki bo bonahala ka ho hlaka hona joale: ho feta boima ba 'mele le botenya bohareng ba bophelo ba bophelo bo beha motho kotsing e kholo ea ho ba le bothata ba' dementia 'hammoho le ho qala ha lefu la Alzheimer. Ka bomalimabe, bo-midlife hape ke nako eo batho ba bangata ba atisang ho ba boima, kaha metabolism e fokotseha hanyenyane 'me ba bangata ba lula ba le boemong bo phahameng.
Leha ho le joalo, ho tseba sena, ho lokela ho lebisa tlhokomelo e khōloanyane lilemong tsa bohareng ho boloka bophelo bo sebetsang le ho ja hantle. Ho na le, ka lehlohonolo, litsela tse ngata tsa ho etsa sena.
Lijo tse ling tse ncha tse ntlafatsang bophelo ba boko li tsejoa e le lijo tsa MIND. Lijo tsena li entsoe ke sehlopha sa bafuputsi ba ileng ba se fa lebitso le lelelele la "Methane ea Mediterranean ea lijo-phetheho ea Systolic Hypertension (DASH) bakeng sa lijo tsa lijo tsa Eurodegenerative d elay (MIND)." Ke molomo, ho netefatsa! Kahoo e tsejoa e le feela lijo tsa MIND.
Palo ena e nka likarolo tsa lijo tsa Mediterranean le lijo tsa DASH tse bontšitsoeng hore li sireletsa ho fokotseha ha maikutlo le lefu la Alzheimer. 'Me, joaloka lijo tse joalo, lijo tsa MIND li fumanoe lithuputsong tsa lipatlisiso ho fokotseha kelellong; e ka boela ea fokotsa kotsi ea lefu la Alzheimer.
Sena se bontša hore seo u se jang ke sa bohlokoa. E le hore u latele lijo tsa MIND, u lokela ho tseba lihlopha tse 15 tsa lijo, tse leshome tsa tsona li nkoa e le "lihlopha tsa lijo tsa bokooa, 'me tse hlano ke lihlopha tsa lijo tseo u lokelang ho li qoba.
Lisebelisoa
Chuang YF, An Y, Bilgel M, le al. Bophelo ba Midlife bo bolelang esale pele ho qaleha ha dementia ea Alzheimer, neuropathology le ho itšireletsa ha motho a le mong. Mol Psychiatry 2015 Sep 1. [Epub pele ho khatiso]
Lefu la tsoekere har'a midlife le ka 'na la potlakela ho tepella maikutlo bophelong ba morao. Harv Health Lett 2015; 40: 8.
> Morris MC, Tangney CC, Wang Y, Sacks FM, le al. METHO ea lijo e amana le ho fokotseha ha lefu la Alzheimer. Alzheimer Dement 2015; 11: 1007-14.
Tolpannen AM, Ngandu T, Kareholt I, et al. Midlife le morao-rao oa 'mele oa' mele le lefu la ho qetela la bophelo la 'dementia: liphello tse tsoang ho sehlopha sa batho ba ka bang teng sechabeng.
RA, ea bitsoang Gunderson EP, Quesenberry CP Jr, et al. Tlhaloso ea boima ba 'mele nakong ea midlife le kotsing ea lefu la Alzheimer le lefu la' meleng oa dementia. Curr Alzheimer Res 2007; 4: 103-9.
Xu WL, Atti AR, Gatz M, Pedersen NL, et al. Midlife ho feta boima ba 'mele le botenya haholo ho eketsa kotsi ea ho qetella e e-na le bothata ba ho ba le' dementia '. Neurology 2011; 76: 1568-74.