Chromosome ea Philadelphia

Chromosome ea Philadelphia ke mokhoa o tobileng oa ho fumanoa liphatseng tsa lefutso la masea a tšoeu a motho-ho fumanoa hoo ho na le moelelo oa kankere ea mali. Hangata ho hlaha ka ho bua ka "Philadelphia chromosome-positive leukemia."

Ka ho khetheha, kankere e ka 'na ea bitsoa "Philadelphia-chromosome-positive (Ph +) e sa foleng ea myeloid leukemia " (CML) kapa "Philadelphia chromosome-positive (Ph +) acute lymphoblastic leukemia" (ALL).

Chromosome e tsosolosa

Karolong e 'ngoe le e' ngoe ea sele, molek'hule ea DNA e kenngoa ka mekhatlo e kang ea khoele e bitsoang li-chromosome. Chromosome e 'ngoe le e' ngoe e entsoe ka DNA e thata-thata-ka makhetlo a mangata-e leng liprotheine tse bitsoang histones. Ntle le hore sele e arohane ka bobeli, li-chromosome ha li bonahale ka hare ho nucleus-eseng le ka tlas'a microscope. Hobane ka seleng e sa arohaneng, DNA ha e tletse le ho feta ka mokhoa o hloekileng, kaha e sebelisoa ke sele ka libakeng tse fapaneng. Leha ho le joalo, DNA e entsoeng ka li-chromosome e tlama ka thata haholo nakong ea karohano ea seleng 'me e bonahala ka tlas'a microscope e le chromosome.

Chromosome e 'ngoe le e' ngoe e na le sebōpeho sa eona, 'me sebaka sa liphatsa tsa lefutso tse itseng li ka fumanoa ho amana le sebōpeho sa chromosome. Ha liphatsa tsa liphatsa tsa lefutso tsa seleng ea motho li kenngoa, li na le li-chromosome tse 23, ka kakaretso ea li-chromosome tse 46 seleng ka 'ngoe.

Ha e le hantle, mefuta e sa tšoaneng ea limela le liphoofolo e na le linomoro tse fapaneng tsa li-chromosome. Ka mohlala, sefofane se na le lihlopha tse 'nè tsa li-chromosome, ha semela se raese se na le 12 le ntja, 39.

Chromosome ea Philadelphia

Chromosome ea Philadelphia e na le pale le maemo, empa e le hore e sebetse, e ka hlalosoa e le ntho e sa tloaelehang ea chromosome 22 eo karolo ea chromosome 9 e fetisetsoang ho eona.

Ka mantsoe a mang, karolo ea chromosome 9 le karolo ea chromosome 22 e senya le libaka tsa khoebo. Ha khoebo ena e etsahala, e baka khathatso liphatseng tsa lefutso - liphatsa tsa lefutso tse bitsoang "bcr-abl" li thehoa ka chromosome 22 moo karolo ea chromosome 9 e kopanyang. Chromosome e fetohileng 22 e bitsoa chromosome ea Philadelphia .

Lisele tsa masapo a bone tse nang le chromosome ea Philadelphia li atisa ho fumanoa ke kankere e sa foleng ea myelogenous 'me ka linako tse ling e fumanoa ke lefu la acute lymphocytic leukemia . Le hoja chromosome ea Philadelphia e atisa ho nkoa e amana le CML le ALL, e ka boela ea hlahella libakeng tse ling, tse kang "phetoho e fapaneng ea Philadelphia," le "lefu la myeloproliferative le sa foleng la chromosome la Philadelphia."

Kahoo u bona, chromosome ea Philadelphia ke phetoho e khethehileng ea liphatsa tsa lefutso e fetohileng letšoao la bohlokoa meriana, e thusang ho khetholla mafu a mang a kankere ka boteng ba eona, le mefuta e meng ea kankere ka ho se be teng.

E le karolo ea tlhahlobo ea bona, lingaka li tla batla boteng ba chromosome ea Philadelphia ho thusa ho fumana hore na mokuli o tšoeroe ke mofuta o itseng oa kankere ea mali.

Chromosome ea Philadelphia e fumaneha feela lisele tse amang mali. Ka lebaka la tšenyo ea DNA, chromosome ea Philadelphia e etsa hore ho be le enzyme e sa tloaelehang e bitsoang tyrosine kinase.

Hammoho le tse ling tse sa tloaelehang, enzyme ena e etsa hore sele ea kankere e hōle ntle ho taolo.

Lingaka li tla batla ho ba teng ha mokhoa ona o sa tloaelehang ha li ntse li hlahloba mehlala ea masapo a hao a marotholi le marulelo ho thusa ho etsa hore o fumane hantle.

Ho khetholloa ha chromosome ea Philadelphia lilemong tsa bo-1960 ho ile ha lebisa tsoelo-pele e khōlō ho phekola CML. Sena se ile sa beha motheo oa nako e ncha ea phekolo ea CML e bitsoang "tyrosine kinase inhibitors," e kang Gleevac (imatinib mesylate) le Sprycel (dasatinib).

Morao tjena, Tasigna (nilotinib) o ile a lumelloa ho phekola batho ba baholo ba sa tsoa fumanoa hore ke Philadelphia chromosome-positive (Ph +) CML boemong bo sa foleng.

Nilotinib e boetse e nkoa e le tyrosine kinase inhibitor.

_Lisebelisoa

_{Goldman, J. le Daley, G. (2007). Lefu la Myeloid le sa foleng. A Melo, J., le Goldman, J. (Eds.) Mathata a Myeloproliferative (pp.1-13). New york. Mokokotlo.}

_{Sherbenou, D. le Druker, B. "Ho sebelisa ho fumanoa ha chromosome ea Philadelphia" Journal of Clinical Investigation August 2007 117: 2067-74.}

_{Adamson PC. Ho ntlafatsa Phello ea Bana ba nang le Kankere: Ntšetso-pele ea Mekhatlo e Ncha e Lebelitsoeng. CA Kankere J Clin. 2015; 65 (3): 212-220.}

_{Nowell PC. Ho fumanoa ka chromosome ea Philadelphia: pono ea motho ka mong. Journal of Investigation ea Bongaka. 2007; 117 (8): 2033-2035.}