MTHFR Gene le TRPV1 Gene e tlatsetsang ho Migraines
Haeba u e-na le bothata ba ho thibela migraine, ho na le monyetla o motle oa hore khaitseli ea hau, motsoal'ae kapa 'mè a etse joalo. Lebaka ke hobane liphatsa tsa lefutso tsa hau li etsa hore u khone ho hlasela migraine.
A re hlahlobe liphatsa tsa lefutso tsa migraine le hore na sena se bolela'ng ho uena le ba lelapa la hau.
Tšebelisano pakeng tsa Genese le Tikoloho ea Hlooho ea Hlooho
Boholo ba lihlooho tse bohloko bo bakoa ke mefuta e mengata ea liphatsa tsa lefutso le tikoloho e sebelisanang le websaeteng e rarahaneng.
Le hoja ba bangata ba lona ba sebetsa ka ho sa feleng ho laola lits'ebeletso tsa tikoloho ka ho qoba ho qoba le ho fetola boitšoaro, ho totobetse hore o ke ke oa fetola liphatsa tsa lefutso tseo u tsoetsoeng le tsona. Leha ho le joalo, ka ho ithuta liphatsa tsa lefutso tse amanang le tšimoloho ea migraine, bo-rasaense ba ka etsa lithethefatsi tse ncha tse lebisang liphatsa tsa lefutso tse itseng, ka tšepo ea ho folisa, le ho fokotsa hlooho ea rona e boima le e senyang.
Mefuta ea liphatsa tsa lefutso e na le karolo efe ho Migraines?
Ho na le karolo ea bohlokoa ea ho ba lefa ho nts'etsopele ea migraine le tse ling tsa hlooho e ka sehloohong . Sena se bontšitsoe ka lithuto tse ngata tsa malapa le mafahla. Empa liphatsa tsa lefutso tsa sebele li fetisetsoa hokae? Ka tlaase mona ke mohlala oa liphatsa tsa lefutso tse peli tse nahanoang hore li phetha karolo ea ho thehoa ha migraine.
Sephatsa se seng sa lefutso se bitsoa liphatsa tsa lefutso tsa MTHFR , e leng nako e telele, methylenetetrahydrofolate reductase. Lefu lena le kenngoa tseleng ea homocysteine. Homocysteine ke amino acid e maling a rona hoo ha e phahame, e ka lebisa ho tšeloa mali ea sekepe, hammoho le ho thunngoa ha lisele tse itseng tsa methapo tse ka 'nang tsa ameha hloohong.
Liphetoho tse ling tsa lefutso lena li 'nile tsa amahanngoa le bobeli ba migraine le hlooho ea hlooho .
Phuputso e 'ngoe ho Pharmacogenetics le Genomics e fumane hore ho basali ba nang le migraine le aura , vithamine supplementation e theolela haholo maemong a bona a homocysteine, mahlaba a migraine le ho holofala ha migraine, ha bapisoa le basali ba ileng ba nka placebo.
Vithamine supplementation e ne e etsoa ka vithamine B6, B9 (folic acid) le B12, tse fumanoeng ho fokotsa maemo a homocysteine maling.
Ho phaella moo, ha sehlopha sa phekolo ea vithamine se hlahlojoa ka hloko, se fumanoe hore bakuli ba nang le bothata bo itseng ba liphatsa tsa lefutso ba MTHFR ba na le ho fokotseha ho hoholo ha maemo a homocysteine, hammoho le boima ba migraine le bokooa ba batho ba nang le bokooa, ho feta ba nang le sekolo se fapaneng . Sebaka sa mofuta o mong oa liphatsa tsa lefutso tse nang le sebaka se itseng ka chromosome e itseng. Tlhaloso ena e bontša hore mefuta e itseng ea liphatsa tsa lefutso e ka susumetsa hore na basebetsi ba tsamaeang hantle ba arabela vithamine ea tlatsetso joang.
TRPV1 (e tloaelehileng e amanang le e ka 'nang eaba e na le mofuta oa Vanilloid Type 1) e nkiloe ho phetha karolo ea bohlokoa ho hlokomelisoang ke migraine - lentsoe le bolelang tsamaiso ea methapo e feteletseng kapa e sebetsang ka matla ho bakuli ba nang le migraine.
Lefu lena le na le karolo ho migraine hyperalgesia le allodynia , maemo a mabeli a ka hlahang nakong ea tlhaselo ea migraine. Hyperalgesia e bolela ho arabela ho eketsehileng ho tsosumetso e bohloko. Allodynia e bua ka boikutlo bo utloisang bohloko bo bakoang ke tšusumetso e tloaelehileng e se nang kotsi, e kang ho ikutloa u sa phutholoha ka tsela e bonolo nakong ea tlhaselo ea migraine.
Lilemong tse 'maloa tse fetileng, lithethefatsi tse amanang le litsela tsa TRP li ithutiloe e le mekhoa ea phekolo ea migraine.
Mohlala o mong oa lithethefatsi tse lebisang mochine oa TRPV1 ke sumatriptan , phekolo e tloaelehileng ea migraine.
Sena se Bolela'ng ho 'na?
Setšoantšo se seholo ke hore migraine e na le matla a liphatsa tsa lefutso. Ka ho ithuta ho eketsehileng ka liphatsa tsa lefutso tse hlahisang motho pele ho migraine, bo-rasaense ba ka qhekella lithethefatsi ho liphatsa tsena tsa lefutso.
Hape, ho utloisisa liphatsa tsa lefutso tsa migraine ho ka felisa moroalo o mong oo batho ba o fumanang, ha ba leka ho laola litlhaselo tsa migraine. Nahana ka ho tšohla histori ea lelapa la hau le mofani oa hao ea tlhokomelo ea bophelo, kaha sena se ka fana ka kutloisiso ea migraine ea hau le ho susumetsa phekolo ea ka moso.
Lisebelisoa:
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Mees JE, Neeb L, Reuter U. TRPV1 ho migraine pathophysiology. Mekhoa ea Mol Med. 2010; 14 (4): 153-159.
Menon S, Leah RA, Roy B, Hanna M, Wee S, Haupt LM, Oliver C, Griffiths LR. Li-genotypes tsa MTHFR C677T le MTRR A66G li hlahisa liketso ka boinotšing ho fokotsa bokooa ba migraine ka lebaka la vithamine supplementation. Pharmacogenet Genomics. 2012 Oct; 22 (10): 741-9.
Rainero, I. Rubino E, Paemeleire K, Gai A, Vacca A et al. Liphatsa tsa lefutso le hlooho e ka sehloohong: ho fumana mekhoa e mecha ea ho phekola litlhaselo. J Headache Pain. 2013; Mar. 12; 14 (1): 61. 14 (1): 61.
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