Ho tse ling, ACE inhibitors joaloka lisinopril sesosa sa ho khohlela le ho ruruha.
Li-enzyme-inhibitors (ACE inhibitors) tsa Angiotensin) tse kang li-lisinopril, captopril le li-enalapril ke meriana ea antihypertensive. ACE inhibitors e sebetsa ka ho fokotsa khatello ea mali 'me hangata e khetha ho khetha tse ling tse kang beta-blockers (nahana propanolol). Leha ho le joalo, batho ba bang ba ACE inhibitors ba hlahisa ho khohlela ho omeletseng kapa ho hlasela hohle hohle, molomo le puo (angioedema) e etsang hore meriana ena e be thata kapa e bolaeang.
ACE Inhibitors ke eng?
ACE inhibitors e thibela li-enzyme tse fetolelang angiotensin tse fetolelang angiotensin ke ho angiotensin II. Ka ho thibela mohato ona o hlokahalang tsamaisong ea renin-angiotensin , ACE inhibitors e khona ho fokotsa khatello ea mali ka ho sebelisa vasoconstriction le ho senyeha ha mosebetsi oa aldosterone.
Aldosterone ke hormone ea steroid (mineralocorticoid) e hlahisoang ke litšoelesa tsa adrenal (zona glomerulosa), tse lutseng liphio tsa hau. Aldosterone e laola ho hloekisoa ha moroto ka liphrone tsa liphio. Ka ho khetheha, aldosterone e sebeletsa ho tlisa sodium le metsi ho potoloha ha hao bakeng sa potassiamo e tsoelang pele le ho ntša metsi. Tlhokomelo, joalokaha e laoloa ke melao ea osmosis, e bolokile khatello ea mali ea sodium le metsi.
Mehlala e meng ea ACE inhibitors:
- lisinopril
- captopril
- perindopril
- enalapril
- benazepril
- fosinopril
ACE inhibitors joaloka lisinopril e sebelisetsoa ho tšoara khatello ea meriana kapa khatello e phahameng ea mali 'me e sebetsa ka ho khetheha ho batho ba nang le mafu a sa foleng le a hlokang pelo.
ACE inhibitors le eona e sebelisoa ho phekola lefu la pelo, tlhaselo ea pelo, ho hloleha ha pelo le ho thibela liketsahalo tsa nakong e tlang tsa pelo. Re lokela ho hlokomela hore ka kakaretso, ACE inhibitors-joaloka mefuta e meng ea meriana ea antihypertensive-ha e sebetse haholo ho fokotsa khatello ea mali le ho thibela ts'oaetso le lefu la pelo Afrika Boroa.
Ka kakaretso, ACE inhibitors e sireletsehile ebile e mamelloe hantle. Haeba ho nkoa ho feteletseng, leha ho le joalo, ACE inhibitors e baka ho se tšoane kapa khatello e tlaase ea mali 'me e liehisa pelo ea hao (bradycardia), hape. Ha motho a hlahisa khatello ea mali e tlaase haholo ho ACE inhibitors, ACE inhibitor e emisoa mme metsi a fanoa ho tlisa likhatello morao. (Hangata bahatelli ha ba hlokehe ho tsosolosa khatello ea mali ea motheo.)
Ho ba nang le ts'ebetso ea ho ba le tšenyo e mpe kapa ba nang le li- NSAID (lithethefatsi tse kang aspirin), ACE inhibitors e ka boela ea senya likarolo tsa 'mele oa hau oa letsoai tse hlahisang hyperkalemia kapa maemo a mangata a potassium . Hyperkalemia e mpe hobane e senya pelo ea hao 'me e ka u bolaea. Ka mor'a ho khaotsa hang-hang ea ACE inhibitor, mofuta ona oa hyperkalemia o phekoloa sepetlele o sebelisa lithethefatsi joaloka calcium, insulin hammoho le tsoekere le tse ling tse joalo.
ACE Inhibitors, Angioedema le Cough
Tlas'a maemo a tloaelehileng, enzyme ea fetola angiotensin e senya bradykinin, moemeli oa ho ruruha o nahannoang hore ke sesosa sa ho khohlela e omileng le ho ruruha ho bonoang hoo e ka bang karolo ea 25 lekholong ea ba nkang lisinopril le tse ling tsa ACE inhibitors. Liketso tse joalo li atile haholo bathong ba Afrika Boroa
Ho ba hlahisang angioedemia, mofuta oa mofuta o mong oa phekolo, mofuta oa ACE inhibitor o khaotsa hang-hang 'me li-steroid le diphenhydramine (Benadryl) li fuoa ho laola ho ruruha. Ho ruruha ho joalo e ka ba tšohanyetso ea bongaka hobane e ka thibela moea oa hau 'me e ka ba nako leha e le efe ha u ntse u le ACE inhibitors. Ka mantsoe a mang, u ka 'na ua nka li-inhibitor tsa ACE ka nakoana pele u e-ba le li-angioedema.
Sefuba se bakoang ke ACE inhibitors ha se hloka phekolo ntle le ho khaotsa lithethefatsi. ACE inhibitors e na le halofo ea bophelo bo khutšoanyane haholo mme e lokela ho hlatsuoa ka hare ho letsatsi.
Haeba uena kapa moratuoa a nka ACE inhibitor joaloka lisinopril le ho khohlela, ka kōpo iphe nako ea ho bona ngaka ea hau bakeng sa tlhahlobo. Ngaka ea hau e ka 'na ea tlohela ACE inhibitor' me ea qala ka meriana e meng ea antihypertensive e kang ARB (ea angiotensin II receptor blocker).
Haeba uena kapa motho eo u mo ratang a tšoeroe ke angioedema le ho senya bophelo ha u ntse u le ACE inhibitor, u se ke ua nka meriana leha e le efe 'me u founele hang-hang 911. Ka mor'a hore u phekoloe ka li-steroids le Benadryl, ngaka ea hau e ka u hlahloba' me ea u fa moriana o mong oa khatello ea meriana . Ka kopo hlokomela hore lithethefatsi ena e ka 'na eaba e ke ke ea e-ba ARB hobane li-ARB li tsebahala ka seoelo se bakang angioedema, hape.
Mantsoeng a ho qetela, liphello tse ling tse bohloko tse bakoang ke ACE inhibitors tse kang khatello e tlase ea mali le khatello ea metsolic (hyperkalemia) hangata li bakoa ke ho sebelisana ho feteletseng, meriana (NSAID) kapa ts'ebetso e holofetseng ea liphio e fetolang tumello. Kahoo, ha u ntse u nka ACE inhibitors, etsa bonnete ba hore u hlahloba khatello ea mali ea hao khafetsa, u latele le ngaka ea hao mme u ikopanye le ngaka ea hau haeba u kile ua ikutloa u soabile kelello, u na le moriri o motlakase, u na le dizzy kapa joalo.
Lisebelisoa
Atkins G, Rahman M, Wright JT, Jr. Khaolo ea 70. Ho tseba le ho phekoloa ha khatello ea kelello. Ka: Fuster V, Walsh RA, Harrington RA. eds. Hurst's The Heart, 13e . New York, NY: Hill ea McGraw; 2011. O fumaneha ka la 18 April, 2015.
Hayashi SA. Khaolo ea 10. Li-Blockers tsa Angiotensin le ACE Inhibitors. Ka: Olson KR. eds. Ho chefo le ho feta ha lithethefatsi, 6e . New York, NY: Hill ea McGraw; 2012. E fumaneha ka la 18 April, 2015.