P-protheine ke antibody-kapa karolo ea anti-e ka hlahisang liteko tsa mali a hau le / kapa moroto, mme boteng ba eona bo ka bolela lintho tse fapaneng. Metsing ea mali e kang myeloma , 'M' ka 'M' protheine 'e emela monoclonal. Protheine ea monoclonal e hlahisoa ke lisele tse sa tloaelehang, tsa kankere kapa tsa precancerous. E bitsoa protheine ea monoclonal hobane ho na le khoele e le 'ngoe, e leng mono-clone ea "lisele tsa kankere tse tšoanang-le lipaha," tsohle li etsa protheine ena.
Protheine ea M e tšoana le sehlahisoa se nang le sekoli, se hlahisoang ke boima; ha e loantše tšoaetso mme ha e sebelise.
Setšoantšong, setlolo sa 'mala o moputsoa oa' mala oa Y, kapa immunoglobulin, ke protheine ea M.
Ntho e kholo e potolohang ka morao ke seleng ea mali, e etsang hore li-antibodies li be teng. Hase li-proteine tsohle tsa M li-antibodies tse kang tse bontšitsoeng. Ka linako tse ling, protheine ea Myeloma ke karolo e le 'ngoe feela ea antibody.
Litlhaloso tse ling tsa M protheine
Molaong oa protheine ea Myeloma, e bolela tlhahiso e sa tloaelehang ea lisele tsa mali tsa 'mele oa' mele oa motho. Ka bomalimabe, "protheine" ea M e ka 'na ea e-ba le litlhaloso tse fapaneng tsa bongaka, ho itšetlehile ka taba kapa boloetse bo ntseng bo tšohloa.
Protheine ea M e ka 'na ea hlalosoa hape ka mantsoe a latelang:
- Monoclonal protein
- Myeloma protein
- Bolokolohi ba immunoglobulin bo sa lefelloeng
- Paraproteins
- Liprotheine tsa Bence Jones
- The spike
- Karolo ea M
Sehloohong sena, re bua haholo ka protheine ea M e amanang le kankere-mme, haholo-holo, ho mefuta e itseng ea kankere ea mali le maemo a tšoaetsanoang a mali le mofu oa masapo.
Leha ho le joalo, liprotheine tse ling tse tummeng tsa M li etsahala meriana, haholo-holo mabapi le likokoana-hloko tse tšoaetsanoang joalokaha ho bontšoa mona:
- M protheine e ka 'na ea emela liprotheine tsa kokoana-hloko ea kokoana-hloko joaloka liprotheine tsa M1 tsa kokoana-hloko ea mafu .
- M protheine e ka sebelisoa ha e bua ka baktheria e itseng, streptococcus pyogenes.
- M protheine, kapa ha e le hantle "protheine ea M" e bohlokoa ho baktheria ea mycoplasma genitalia .
Kankere ea Mali
Liprotheine tsohle tsa anti-inflammone li bitsoa immunoglobulins. Protheine ea protini ke immunoglobulin-kapa karolo ea immunoglobulin-e hlalositsoeng e le monoclonal, e bolelang hore e hlahisoa ke khanya e le 'ngoe ea lisele tsa bothata. Ha hoa tloaeleha hore 'mele o be le likopi tse ngata haholo tsa protheine e tšoanang joalo ka kakaretso e hlaha ka myeloma,' me ho feteletseng hoa fumanoa lithutong tsa laboratori. E ka boetse ea bakela mathata mathata 'meleng, haholo haeba maemo a phahame haholo.
Moo e Tsoang Teng
In myeloma e mengata, protheine ea M e hlahisa lisele tse ngata tsa mali tsa mali. Ka tlhaho, lisele tsa plasma li tla hlahisa li-antibodies tse ngata. Bophelong bo tloaelehileng kapa bo phetseng hantle, palo ea lisele tsa mali tsa mali li khona ho hlahisa mefuta e mengata ea li-antibodies-tse bitsoang polyclonal antibodies, kapa li-immunoglobulin tse nang le polyclonal. Ha lisele tsa mali tsa mali li e-ba le kankere, hangata ho na le seleng e le 'ngoe, e mpe haholo e entseng hore ho be le litone tse ngata tse tšoanang. Li-minion tsena ke li-clone tsa sele e le 'ngoe,' me li etsa liprotheine tse le mong feela. Kaha ho na le lisele tse ngata tsa mali, li atisa ka mokhoa o sa tloaelehang, li etsa liprotheine tse ngata tsa monoclonal. Ho hongata, kapa spike, ka bophara ba protheine e le 'ngoe feela, ho ka fumanoa litekong tsa laboraka.
Tsela ea likokoana-hloko tsa Monoclonal
Selefouno se seng le se seng se entsoe ka likarolo tse 'nè. Ho na le liketane tse peli tse telele ka hare, le liketane tse peli tse khutšoanyane ka ntle. Setšoantšong, o ka bona seleng ea mali e nang le antibody le li-antibodies tse ling tse nyenyane ka morao.
Liketane tse khanyang, kapa tse khutšoanyane, ka ntle ho mela le "blue Y" setšoantšong, li boetse li bitsoa liprotheine tsa Bence Jones , kapa lihlopha tse khanyang tsa immunoglobulin . Tabeng ena, ke karoloana e nyane ea anti-antibody. Ha protheine e le leseli le khanyang, e le lekaneng, ha e le hantle, e ka feta liphio 'me ea kena ka morong.
Kahoo, haeba feela ho hlahlojoa mali ho etsoa lihlopha tse khanyang li ka hloloheloa kaha li kene ka morong.
Ka lehlakoreng le leng, haeba protheine ea M e e-na le immunoglobulin eohle-e kholo eohle Y e setšoantšong-joale e ka fumanoa maling hobane e kholo haholo hoo e ke keng ea fetela meleng. 'Me kaha liprotheine tsena tse kholo li bolokiloe, ho haha liprotheine tse joalo tse ngata ka liphio ho ka baka mafu a liphio.
Bohlokoa
- Ho lemoha: M protheine e atisa ho fumanoa mefuteng e mengata ea myeloma le maemo a mang a 'maloa
- Ho senyeha ha liphio: Ha liprotheine li le ngata ka ho lekaneng 'me li ngata ka ho lekaneng tabeng ea malignancy ho koala lihlopha tse sebetsang tsa liphio, sena se ka lebisa ho lefu la liphio' me qetellong ho hloleha ha liphio.
- Ho itšetlehile ka litšobotsi tsa protheine e entsoeng ka sephiri, liphello tse ling tse kotsi li ka khoneha.
Mali le Marrow Maemo a Nang le Li-Protein tse eketsehang
Maemo a ka 'nang a fella ka boemo bo phahameng ba liprotheine ka teko ea moroto kenyeletsa:
- Myeloma - Tlhahlobo ea moroto e tla ba ntle bakeng sa protheine ea M ho 50 ho ea ho 80% ea batho ba nang le myeloma.
- MGUS - Monoplonal gammopathy ea bohlokoa bo se nang motheo e ka ba le boemo bo phahameng.
- Macroglobulinemia ea Waldenstrom - Kankere ena, e akarelletsang lisele tse ka pele ho lisele tsa mali, e ka 'na ea e-na le protheine e phahameng ea M.
Maemong a mang, lisele tse bakang protheine ea M li kotsi, 'me li ka hlasela lesapo, lymph nodes, sebete, spleen, kapa litho tse ling. Sena ke se etsahalang ho tse ngata tsa myeloma, plasmacytoma e le mong, le Waldenström macroglobulinemia.
Maemong a mang, protheine ea M e hlahisoa ke lisele tse nyane tse sa fokolang tsa lisele tse atolositsoeng, 'me sena ha se bake matšoao. Ho joalo ka monoclonal gammopathy ea bohlokoa bo sa bolelloang MGUS.
Lentsoe le Tsoang ho
Maemo a mangata a ka baka monmlonal gammopathy, spike ka protheine e le 'ngoe; 'me, hase maemo ana kaofela a nang le kankere. O ka ba le protheine e nang le mathata a mang a maiketsetso, joaloka systemic lupus erythematosus, ramatiki ea ramatiki, le ramoriki ea psoriatic. O ka ba le tšoaetso ea kokoana-hloko ea Hepatitis C le HIV / AIDS. U ka ba le eona le lefu la ve Willebrand le fumanoeng, boloetse bo sa tloaelehang ba ho tsoa mali. Ka hona, maemong a mangata, sesosa sa protheine ea M ke sa bohlokoa ho feta ho ba teng ha sena feela.
Lisebelisoa:
Leukemia le Lymphoma Society. Tsejoa. https://www.lls.org/disease-formation/myeloma/diagnosis
Papanikolaou X, Rosenthal A, Dhodapkar M, et al. Phallo ea cytometry e hlalositsoeng ke cytoplasmic immunoglobulin index ke sesosa se ka sehloohong sa ho fetela ha li-gammopathies monoclonal monoclonal ho multiple myeloma (tlhahlobisiso ea tlhahiso ea SWOG S0120). Mali a Kankere ea Journal. 2016; 6 (3): e410-.