CD20 ke letšoao la CD-molek'hule e ka holim'a seleng e ka sebelisoang ho khetholla le ho beha sele e khethehileng 'meleng. CD20 e fumanoa holim'a lisele tsa B, empa a re khutliseng morao 'me re nolofalletse ho utloisisa sena.
Libaka tsa CD ke eng?
Li-CD ke limolek'hule tse fumanehang holim'a lisele tsa 'mele ea rona. U ka ba utloa ba bitsoa li-antigen - 'me antigen ke ntho leha e le efe e ka holim'a seleng e ka tsejoang ke' mele oa rona oa 'mele.
Ka mohlala, lisele tsa rōna tse tšoeu tsa mali li ka 'na tsa lemoha likokoana-hloko holim'a libetsa tsa baktheria' me lisele tse tšoeu li na le bokhoni ba ho arabela ho seo ho nkoang hore ke kotsi.
Sele e 'ngoe le e' ngoe ea 'mele ea rona e na le letšoao la CD,' me ho na le li-antigen tse fetang 250 tse ngata. Mantsoe a CD a emela lihlopha tsa ho khetholla - hape, ke tsela e le 'ngoe eo mefuta e fapaneng ea lisele e ka bolelloang ka eona. Ho tseba ho tseba lintlha tsena tsa CD ho ka ba bohlokoa ka ho khetheha ha u sa khone ho hlokomela mofuta oa sele.
Lik'hamphani tsa CD, B li-cell, le li-cell tsa T
Lymphomas ke kankere ea mofuta oa sele e tšoeu ea mali e tsejoang e le lymphocytes. Ho na le mefuta e 'meli e meholo ea lymphocyte - li-lymphocyte B kapa lisele tsa B , le li-lymphocyte tsa T kapa lisele tsa T. Mefuta e 'meli ea lymphocyte e thusa ho sireletsa' mele ea rona ho tsoa ho mafu.
Lisele le lisele tsa T li na le mesebetsi e fapaneng, 'me kankere ea sele e' ngoe le e 'ngoe ea B e sebetsana ka tsela e fapaneng le kankere ea lisele tsa B.
Ho sa tsotellehe phapang ena kaofela, ho ka ba thata ho bolela phapang pakeng tsa 2 tlas'a microscope. Mofuta o tšoanang le oa 2 mafahla a tšoanang le a itšoarang ka tsela e fapaneng haholo mme a arabela batho ka tsela e fapaneng empa a shebahala ka ntle ka ntle.
CD20 ke eng?
CD20 ke antigen e fumanoang holim'a lisele tsa B empa eseng lisele tsa T.
Mohlala oa hore na CD-20 e ka sebelisoa joang ho bolella lisele tse arohaneng e fanoa mona:
Ho na le lik'hemik'hale tse peli tse sa tšoaneng tse shebahalang joaloka mafahla a tšoanang ka tlas'a microscope, empa li na le lithuto tse fapaneng haholo tsa mafu 'me li arabela ka tsela e fapaneng le litlhare: Ho fetisa boholo ba l cell lymphoma (DLBCL) ke kankere e amang lisele tsa B. Ka tlas'a microscope lisele li shebahala joaloka lisele tsa T tse nang le kankere tse fumanoang ka lisele tse khōlō tsa lymphoma (ALCL) . Li-cancers tsena ka bobeli li na le lisele tse ngata tse "kankere" tse shebahalang 'me e ka ba tse sa tsejoeng. CD20 e ka sebelisoa ho bontša phapang pakeng tsa lik'hemik'hale tsena tse peli meleng ea liteko tseo CD20 e atisang ho ba le boemo bo botle tabeng ea DLBCL empa e le mpe ho ALCL.
E Lekoa Joang?
Mokhoa o khethehileng o bitsoang immunohistochemistry (IHC) o sebelisetsoa ho khetholla CD20 le ho fumana hore na sele e sa tloaelehang ea kankere ea mali e tšoeu (lymphocyte ka ho khetheha) ke B-cell kapa T-cell.
Ho Tšoaroa Joang?
Kalafo le ho phatloha ha B-cell le T-cell lymphomas hangata li fapane.
Sehlopha se secha sa meriana e bitsoang monoclonal antibodies e sebetsa hantle bakeng sa lymphomas tse ling. Feela joalokaha 'mele ea rona e etsa hore li-antibodies li loantše libaktheria le likokoana-hloko, li-antibodies tse monoclonal ke li-antibodies tse entsoeng ho loantša lisele tsa kankere.
'Me feela joalokaha' mele ea rona e etsa li-antibodies tse hlokomelang likokoana-hloko libaktheria likokoana-hloko, likokoana-hloko tsena tsa monoclonal li lemoha likokoana-hloko holim'a lisele tsa kankere; tabeng ena, CD20.
Ho sebelisa moriana o mong oa monoclonal o tlama ho CD20 o tla sebetsa feela khahlanong le kankere e nang le li-antigen tsa CD20 holim'a metsi, joalo ka ALCL ka mokhoa o hlalositsoeng ka holimo.
Monoclonal Antibody Treatment le CD20
Ho na le li-antibodies tse ngata tsa monoclonal tse seng li sebelisoa hona joale. Likokoana-hloko tse monoclonal tse tšoarang li-lymphomas le leukemias tsa B li-CD20 antigen tse ka holim'a lisele li akarelletsa:
- Rituxan (rituximab)
- Zevalin (ibritumomab tiuxetan)
- Bexxar (tositumomab)
- Gazyva (obinutuzumab)
- Arzerra (ofatumumab)
Le hoja kaofela ba tlama CD20, ho na le phapang pakeng tsa li-antibodies tsena. Tse ling li bitsoa chimeric e kang rituximab, e bolelang hore li-bio-engineer li sebelisitse 'ho kopanya lisebelisoa tsa kaho' ho etsa li-antibody, tse ling tsa batho, tse ling tsa mouse; tse ling li na le botho ba motho (obinutuzumab) 'me tse ling ke batho ka botlalo (ofatumumab), e bolelang likarolo tsohle li tsoa liphatseng tsa liprotheine tsa batho. Joale, ntlha e 'ngoe e khethollang ke hore tse ling li amahanngoa le li-radioactive elements (ibritumomab tiuxetan le tositumomab).
Ho Sebetsana le Lymphoma
Ha u se u fihlile leqepheng lena, u nka mohato o moholo oa ho ba karolo ea mafolofolo tlhokomelong ea hau. Liphuputso li fumane hore ho ithuta haholo ka lefu la hao ka hohle kamoo ho ka khonehang , le ho bapala karolo e mafolofolo tlhokomelong ea hau, ha ho thuse feela ho sebetsana le matšoenyeho a kankere empa ho ka thusa le liphello hape. Finyella lelapa le metsoalle. Sheba sebopeho se setle sa Inthaneteng sa batho ba tšoeroeng ke kankere ea mali le lymphoma - batho bao u ka fihlelang ho 24/7 bakeng sa tšehetso le lipotso. Etsa bonnete ba hore u moemeli oa hao ka tlhokomelo ea kankere ea hau . Meriana e fetoha 'me ba oncologists ha ba mamelle feela empa ba lebeletse ho sebetsa ka lehlakore le uena ho lokisetsa lenaneo la phekolo le molemo ho uena ka motho.
Lisebelisoa:
National Cancer Institute. Batho ba baholo bao e seng Hodgkin Lymphoma Treatment - Health Professional Version (PDQ). E fetotsoe 01/15/16. http://www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq