Ho ela hloko matšoao a PML ho feta a Ts'ebetsong ea MS Relapse
Mokhoa o tsoelang pele oa leukoencephalopathy (PML), ke ntho e sa tloaelehang empa hangata e bolaeang e bakoang ke kokoana-hloko ea JC . Ka tloaelo kokoana-hloko ena e hlahlojoa ke 'mele ea hau oa' mele e le hore e se ke ea baka tšenyo.
Leha ho le joalo, haeba tsamaiso ea 'mele oa hao ea' mele ea ho itšireletsa mafung e fokolisoa ke lefu le kang lefu la HIV / AIDS , kankere ea mali , kankere e 'ngoe, kapa kankere e' ngoe, kapa kokoana-hloko, kokoana-hloko e ka boela ea senya boko ba hao.
Bothata ba boko bo bakiloeng ke PML bo ka lebisa matšoao a sa tšoaneng.
Le hoja PML e le ntho e sa tloaelehang ka kakaretso, ho na le ho ameha haholo haeba u e-na le multiple sclerosis (MS) hobane meriana e meng ea immunosuppressant e sebelisetsoang ho phekola lefu lena e eketsa menyetla ea ho hlahisa PML.
Tysabri (natalizumab) e bonahala e amahanngoa le kotsi e kholo ea PML. Leha ho le joalo, meriana e meng ea MS ea immunosuppressive e ka 'na ea baka kotsi, ho akarelletsa Gilenya (fingolimod), Tecfidera (dimethyl fumarate), Ocrevus (ocrelizumab), mohlomong le tse ling.
PML Matšoao
MS ka boeona ha e eketsa kotsi ea PML. Empa haeba uena kapa moratuoa oa hau a noa meriana e fetolang lefu e thibelang tsamaiso ea 'mele ea ho itšireletsa mafung, ho itlhalosa ka matšoao a PML ho u lumella hore u ikakhele ka setotsoana' me u tsebise ho hlahloba mathata ana a tebileng.
Joaloka matšoao a MS, ba kopantsoeng le PML ba fapana, ho itšetlehile ka libaka tsa boko tse amehang.
Matšoao a ka kenyelletsa:
- Bofokoli, hangata ka lehlakoreng le leng la 'mele
- Matla a ho nahana a sa nahaneng, ao hangata a iponahatsang e le pherekano le / kapa ho lahleheloa ke mohopolo
- Ho thata ho bua
- Tšebelisano e mpe, e tloaelehileng e le ho tsieleha kapa ho tsamaea mathata
- Mathata a ho bona, a kang pono e hlabang kapa ho se bone hantle sebakeng se itseng sa tšimo ea hau ea ponahalo
- Liphetoho tsa botho
- Boikutlo bo sa tloaelehang kapa ho lahleheloa ke maikutlo sebakeng sa 'mele oa hau
- Lits'oants'o, le hoja sena se sa tloaeleha
PML vs. MS Relapse
Matšoao a PML a atisa ho khetholla ho tsoa ho ts'oaetso ea MS hape. Sena ha se makatse kaha mafu a mabeli a baka ho fokolloa ha metsi, ho bolelang ho timetsoa ha ntho e sireletsang e potolohileng methapo. Ho lahleheloa ke ntho ena e sireletsang, e bitsoang myelin, e sitisa phetiso ea lipontšo tsa motlakase pakeng tsa boko ba hao le 'mele.
Hobane matšoao a PML le a ho khutlela ho MS a ka 'na a e-ba joalo, ho thata ho tseba PML matsatsing a pele a lefu lena. Seo se boletse, lebelo la tsoelo-pele ea matšoao a macha ke letšoao le thusang ho khetholla hore na ba bakoa ke PML kapa MS hape. Hangata matšoao a PML ha a hlahe ka tšohanyetso empa ho e-na le hoo a ntshetsa pele mme a tsoelapele ka matsatsi a mangata ho isa ho libeke
Lingaka li ka utloisisa ka ho hlaka hore PML e tsoa ho MS ka ho hlahloba ka hloko matšoao a motho. Hobane PML ke tšoaetso e atileng ea boko, e atisa ho baka matšoao a mabeli kapa a ntseng a mpefatsa, athe letšoao le le leng le joalo le ka 'na la e-ba le ts'oaetso ea MS hape. Leha ho le joalo, sena ke feela leseli, eseng molao o thata le o potlakileng.
Tsela e 'ngoe e ka sehloohong ea ho khetholla PML ho ts'oaetso ea MS ke ho hlahloba boitsebiso ba MRI ba boko ba motho ea amehileng.
Joaloka MS, PML e baka lisosa tsa boko bo bonahalang ho MRI, empa li atisa ho fapana le liso tsa MS tse tloaelehileng ka boholo, sebōpeho, sebaka le litšoaneleho tse ling.
Moferefere oa mokokotlo ho leka tlhahlobo ea cerebrospinal bakeng sa kokoana-hloko ea JC e boetse e sebelisetsoa ho netefatsa hore na lefu la PML le fumanoa joang. Qetellong, ka nako e 'ngoe bokopi bo ntse bo etsoa.
Lentsoe le Tsoang ho
Ha re utloisisa hore esita le monyetla o moholo oa ho ba le PML ke taba e tebileng haholo ha u noa meriana e meng ea phekolo ea MS. Haeba u le Tysabri, Gilenya, Tecfidera, Ocrevus, kapa meriana e meng ea immunosuppressant bakeng sa MS 'me u hlokomela matšoao afe kapa afe a macha kapa a mpefala, ikopanye le ngaka hang-hang.
Le hoja matšoao ana a sa bontše tsoelo-pele ea PML, tlhahlobo ea bongaka ea potlakase ke ea bohlokoa hobane tšoaetso ena e sa tloaelehang ea boko ke bophelo bo kotsing. Tlhahlobo ea pele ea tlhahlobo ea mali e u fa monyetla o motle oa sephetho se setle ha u ka hlahisa PML.
> Mehloli:
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> Greenlee LE. Progressive Multifocal Leukoencephalopathy (PML). Ka: Porter RS, Kaplan JL, Lynn RB, et al. Merck Manual Professional Version .
> Maas RPPWM, Muller-Hansma AHG, Esselink RAJ, et al. Tšebelisano ea Meriana e Kopantsoeng le Lithethefatsi Leukoencephalopathy: Meriana ea Meriana, ea Radiological le ea Cerebrospinal Analysis ea Liketsahalo tse 326. J Neurol . 2016; 263 (10): 2004-2021.
> Mokhatlo oa Sechaba oa Mathata a Tloaelehileng. (2015). Progressive Multifocal Leukoencephalopathy.
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