Bafuputsi ba bang ba lumela hore se-amyloid se senya khopolo-taba e hlalosang hantle sesosa sa lefu la Alzheimer .
Le hoja lipotso tse ngata li ntse li sa arajoe, li-amyloid li senya khopolo-taba e hlalosang hore ho bokella ho feteletseng peptide e bitsoang amyloid-beta ke ketsahalo ea bohlokoa ho lefu la Alzheimer: Ho bokella hona ho hlahisa letoto la liketsahalo tse lebisang lefung la lisele tsa boko, 'me qetellong, Lefu la Alzheimer.
Kamoo Amyloid-Beta e ka Bakang Alzheimer's
Amyloid-beta e thehoa ho tsoa ho protheine e kholo e bitsoang amyloid precursor protein (APP). Bafuputsi ha ba tsebe hantle mosebetsi oa APP, empa ho ka ama mosebetsi oa lisele tsa boko. Li-enzyme tse khethehileng (tse bitsoang secretase) li khaola liprotheine tsena libakeng tse itseng, 'me se seng sa lihlahisoa tsa "cleavage" ena ke peptide ea amyloid-beta. Li-peptide tsena tse nang le amyloid-beta li kopana ka se bitsoang oligomers, 'me ho ea ka li-oligomers tse hlahisang maikutlo, ke li-oligomers tsena tse nang le chefo ho lisele tsa boko, tse bakang mathata a pele a ho nahanisisa a lefu la Alzheimer. Hamorao, li-oligomers tsena li etsa li- plaque tse nang le tšoaetso ea lefu la Alzheimer, empa ke li-oligomers-ho fapana le li-plaques-ke tsona tse hlileng li nang le chefo.
Le hoja mehlala e mengata ea bopaki ba tšehetso ea li-amyloid e senya khopolo-taba, ho na le mathata a 'maloa ho eona.
Taba e 'ngoe ke hore ho na le boloetse bo tloaelehileng ba lefu la Alzheimer. Ho e 'ngoe, li-deposit tsa protheine e' ngoe e bitsoang litau tsa mofuta oa tau tse tsamaisanang hantle le mathata a kelello ka lefu la Alzheimer ho feta plaque. Qetellong, ho na le likhopolo tse ling tse fapaneng, tse kang mongochondrial cascade hypothesis, tse hlalositsoeng e le tlhaloso ea se bakang lefu la Alzheimer.
Mohloli:
Christensen DD. Lefu la Alzheimer: nts'etso-pele ho nts'etsopele ea mafu a khahlanong le bo-amyloid-phekolo ea phekolo. CNS Spectr. 2007; 12: 113-123.
-Kehlooho e hlophisitsoeng ke Esther Heerema, MSW