Na Phekolo ea Gene e ka Sebelisoa ho Tšoara Botenya?

Hona joale bo-rasaense ba fumana liphatsa tsa lefutso tse amanang le botenya haholo. Mofuta o mong oa liphatsa tsa lefutso, o tsejoang e le FTO, o 'nile oa fumanoa o e-na le botsoalle bo tobileng le botenya.

Botenya ba Master Switch

Hona joale bafuputsi ba fumane hore liphatsa tsa lefutso tsa FTO li ka 'na tsa e-ba le senotlolo sa hore na ke batho bafe ba lebisitseng ho nona haholo.

Ka mohlala, bo-rasaense ba fumane hore liphatsa tsa lefutso tsa FTO li ka ba le tšekamelo ea ho ja lijo tse ngata le ho ntlafatsa botenya ba bacha .

'Me ha ho entsoe bakuli ba ka bang 1 000 Afrika Boroa, bo-rasaense ba fumane liphatsa tse' nè tsa liphatsa tsa lefutso (e 'ngoe ea tsona e amanang le liphatsa tsa lefutso tsa FTO) tse neng li amana le BMI e phahameng ha a le lilemo li 13.

Phuputso e 'ngoe e shebileng liphello tsa FTO ho bana ba fetang 3 000 ba Chaena e fumane hore liphello tsa FTO ka holimo ho BMI li boetse li lebisitse kotsing e amanang le khatello e phahameng ea mali (e leng khatello ea mali), e tsejoang e bakiloe ke botenya.

Lefu la FTO le boetse le bonahala le amahanngoa le liphello tsa takatso ea lijo, lijo tsa motsoako le boima ba 'mele (BMI). Ka lebaka la liphetho tsa morao-rao tsa lipatlisiso, bafuputsi hona joale ba lumela hore ho na le kamano pakeng tsa FTO, ho ja joala, le botenya. Ba bang ba se ba le haufi le ho bitsa FTO "mastermind" ha ho tluoa tabeng ea liphatsa tsa lefutso tsa botenya le ho ikemisetsa bokamoso ba BMI.

Kamoo FTO e ka "Fetolang" Botenya

Tse ling tsa mefuta-futa ea liphatsa tsa lefutso (nahana hore tsena e le "liphetoho" tse fapaneng tsa liphatsa tse tšoanang tsa lefutso tse ka fumanoang) tsa liphatsa tsa lefutso tsa FTO li fumanoe li kopantsoe eseng feela ka botenya empa le kankere hammoho-'me, ka mokhoa o hlollang, mefuta e mengata ea kankere botenya-bo amanang le bona.

Ho litoeba, bafuputsi ba hlokometse hore mathata a mang a ts'ebetsong ea enzyme e amanang le FTO a ka thibela kapa a tima li-genese tse ling tse laolang metabolism. Hona, ho ka etsa hore ho boloke mafura ka mokhoa o sa lokelang, kapa ho ba le "metabolism e liehang". Sena se ka boela sa lebisa Mofuteng oa lefu la tsoekere oa Mofuta oa 2, e leng lefu le leng le amanang le botenya.

Bafuputsi ba hlokometse hore ho sebelisa likarolo tse itseng tsa lefutso la FTO ho ka fetola boima ba 'mele le metabolism ho litoeba, ho kenyeletsa le tsela eo mafura a bolokiloeng ka eona-esita le ntle le phetoho ea ho ikoetlisa kapa takatso ea lijo.

Therapy Therapy to Treat Meal

Le hoja ha ho na phekolo e nepahetseng ea liphatsa tsa lefutso e teng hona joale bakeng sa phekolo ea botenya, bo-rasaense ba na le tšepo ea hore liphatsa tsa lefutso tse kang FTO "liphatsa tsa lefutso" li tla lebisa litabeng tsa phekolo ea nakong e tlang. Pele ho moo, leha ho le joalo, ho na le tse ling tse ngata tse ntseng li lokela ho ithuta ka liphatsa tsa lefutso ka mor'a botenya.

Lisebelisoa:

Claussnitzer M, Dankel SN, Kim KH, Quon G, et al. FTO e mengata ea boima bo feteletseng le adipocyte e soabisang batho. N Engl J Med 2015 Aug 19. [Epub pele ho khatiso]

Liu C, Mou S, Pan C. Sephatsa sa lefutso sa FTO rs9939609 polymorphism e bolela esale pele kotsi ea lefu la pelo: ts'ebetso e hlophisitsoeng le mokhoa oa ho etsa lipatlisiso. PLoS One 2013; 8: e71901.

Lombard Z, Hohle NJ, van der Merwe L, et al. Litakatso tsa lefutso tsa liphatsa tsa lefutso li amahanngoa le moelelo oa 'mele oa batho ba batšo ba Afrika Boroa: thuto ea liphatsa tsa lefutso. BMJ Open 2012; 2 (3).

Micali N, Tšimo ea AE, Letlotlo la JL, Evans DM. Na botenya bo bakoa ke liphatsa tsa lefutso tse amanang le ho itlopa joala lilemong tsa bocha? Botenya (Silver Spring) 2015; 23: 1729-36.

Smemo S, Tena JJ, Kim KH, Gamazon ER, le al. Mefuta-futa e amanang le botenya ka har'a mofuta oa FTO maqhubu a nako e telele a sebetsang le IRX3. Tlhaho 2014; 507: 371-5.

Xi B, Zhao X, Shen Y, le al. Mekhatlo ea botenya ba ho nona haholo ke loci le khatello ea kelello ho bana ba Chaena. Int J Obes (London) 2013; 37: 926-30.

Zhao X, Yang Y, Sun BF, Zhao YL, Yang YG. FTO le botenya: mekhoa ea botsoalle. Curr Diab Rep 2014; 14: 486.