Kamoo lisele tsena li leng bohlokoa kateng bakeng sa ho fumana lefu
Ho baeloji le meriana, sekoti "-blast" e bolela lisele tse sa tsejoang tse tsejoang e le lisele tsa pele-pele kapa lisele tsa stem. O ka ba le ho phatloha ho hlahisang mefuta eohle ea lisele tse khethehileng tse fapaneng. Ka mohlala, li-neuroblasts li hlahisa lisele tsa methapo le li-angioblasts li hlahisa lisele tse mafura. Feela joalokaha methapo le metsoako e mafura li hlaha ho tloha lisele tse sa tsoeng pele, lisele tsa mali li boetse li tsoa lisele tse sa tšoaneng tse nang le mali, kapa tse phatsimang, mofuteng oa masapo.
Lisele tsa mali li tsoela pele ho thehoa hore li nkeloe sebaka ke tse tsofetseng kapa tse tsofetseng.
Kahoo ke hobane'ng ha e le habohlokoa ho tseba ka ho phatloha? Haholo-holo, lisele tse phatsimang tsa marrow?
Kaofela re na le ho phatloha. Ha e le hantle, re ile ra qala ho phatloha, blastocyst e le hantle-e leng jumble ea lisele tse arohaneng nako e lekaneng ea ho ba lesea le sa tsoa emoloa. Ntho ea bohlokoa ea ho tseba ke hore ponahalo ea mefuta e sa tšoaneng ea ho phatloha likarolong tse sa lebelloang tsa 'mele kapa tsoelo-pele ea ho phatloha ho sa tloaelehang e ka ba pontšo ea mafu kapa kankere.
Bone Marrow e Blastla Lisele
Mongoaneng o phetseng hantle, lisele tse nang le mali tse tsejoang e le lisele tsa mali tsa hematopoietic li fetoha lisele tse khubelu tsa mali, lisele tse tšoeu tsa mali le liplatelete ka mokhoa o bitsoang hematopoiesis . Tshebetso ena e etsahala ho pholletsa le bophelo bohle ba hao. Sekala sa stem se khetha tsela ea tsoelo-pele e le 'ngoe ea lisele tse peli, lisele ea lymphoid kapa cell myeloid line. Meleng ea cellyelo ea myeloid, lentsoe "ho phatloha sele" le bolela myeloblasts kapa ho phatloha ha myeloid.
Tsena ke lisele tsa pele ka ho fetisisa le tse ngata ka ho fetisisa tsa semeloid cell line.
Le hoja liseleng tsa myeloid cell cell li etsa hoo e batlang e le karolo ea 85 lekholong ea lisele tsa masapo, karolo e ka tlase ho karolo ea 5 lekholong ea mokoallo e lokela ho phatloha lisele.
Myeloblasts e hlahisa lisele tse tšoeu tsa mali . Lelapa lena la lisele tse tšoeu tsa mali le akarelletsa li-neutrophils, li-eosinophil, li- basophil le li-monocyte, le macrophages.
Ho ba teng ha myeloblasts tsena ho fumanoang ho potoloha mali ho ka ba letšoao la bohlokoa la maloetse a mang a kang a myelogenous leukemia le metsoako ea myelodysplastic.
Mathata a Myeloblast
Tabeng ea lefu le matla la myelogenous leukemia (AML) le myelodysplastic syndromes (MDS) , ho na le ho tlōla ho tlōla ha myeloblasts e sa tloaelehang. Lisele tsena li sitoa ho ntshetsa pele ho lisele tse tšoeu tsa mali.
Moriana o nang le kankere ea mali haholo ke mofuta oa kankere o tsamaeang ka mabitso a mangata a mangata, a kang a myelocytic leukemia, mahlaba a maholo a myelogenous leukemia, kankere e matla ea granulocytic leukemia, kapa ka linako tse ling e le AML. E atile haholo ho batho ba baholo. Maemo a mangata a AML a hlahisoa ho tloha lisele tse neng li tla fetoha lisele tse tšoeu tsa mali ntle le lymphocyte, leha ho le joalo, maemong a mang a AML a hlahisa mefuta e meng ea lisele tse entsoeng mali.
Myelodysplastic syndrome ke sehlopha sa mathata a amanang le tlhahiso ea lisele tse ncha tsa mali maling a masapo. Mafu ana, 'mele oa masapo o hlahisa lisele tse sa tloaelehang tsa lisele tse sitoang ho hōla hantle le tse sa khone ho sebetsa.
Ts'ebetso ena e sa tloaelehang e qala ho nka mofu 'me e thibela tlhahiso ea linomoro tse lekaneng tsa mefuta e meng ea mali, tse kang liplatelete, lisele tse khubelu tsa mali le lisele tse tšoeu tsa mali.
Ha e le hantle, tlhahiso ea likokoana-hloko tsa leukemua e ka 'na ea e-ba joalo hoo masea a seng makae a seng a ntse a tšoloha ho tloha lefung la masapo a fetela hohle. Ho ba teng ha lisele tsa lisele ka tekanyo e feletseng ea mali (CBC) ka hona ho belaella haholo ka kankere ea mali. Lisele tse phatlohang ha li atlehe ho fumanoa mali a potolohang a batho ba phetseng hantle.
> Mehloli:
> Mokhatlo oa Kankere oa Amerika. Li-acute lemonia leukemia li khetholla joang? La 22 February, 2016.
> Larson RA, Le Beau MM. Matšoao a Mafu le Therapy Ha ho Atlehile Promyelocytic Leukemia le Tse ling "Kotsi e Ntle" Li-Acute Myeloid Leukemia li Etsahala e le Myeloid Neoplasm e Amanang le Phekolo. Mediterranean Journal ea Hematology le mafu a tšoaetsanoang . 2011; 3 (1): e2011032.
> Zahid MF, Parnes A, Savani BN, Litzow MR, Hashmi SK. Merioplasms e amanang le phekolo ea meriana - re ithutile eng ho fihlela joale? World Journal of Stem Cell . 2016; 8 (8): 231-242.
> "Tlhaloso e hlakileng ea Hematopoiesis le Immunology: Tlhaloso ea Baemeli ba Hematopoietic Bakeng sa ho Fetisetsa Lisele" ho Ezzone, S. (2004) Hematopoietic Plant Stemplantation Plant: Manual ea Mokhatlo oa Booki oa Booki ba Incology: Pittsburgh, PA (pp.1- 12).