P53 ke eng le hore na e bapala karolo efe kankere?
P53 Gene ke eng?
Hantle-ntle palo ea liphatsa tsa lefutso e na le karolo efe ho nts'etsopele le nts'etsopele ea kankere?
P53 Gene ke Gene ea khatello ea tumor
Pene ea p53 ke liphatsa tsa lefutso tse hlahisang protheine e thibelang nts'etso-pele le kholo ea lihlahala (ho phaella mesebetsing e meng). E tsejoa e le setho sa khatello ea liphatsa tsa lefutso . Haeba lefutso lena le fetoha-ke hore, le fetotsoe ka tsela e itseng ka tikoloho kapa lefa, lisele tse senyehileng li lumelloa ho phela, 'me qetellong li fetoha lisele tsa kankere.
P53 Gene Mutation ke Tloaelehileng
Phetoho ea liphatsa tsa lefutso tsa p53 (e teng ka chromosome 17) ke phetoho e tloaelehileng ka ho fetisisa e fumanoang liseleng tsa kankere 'me e teng ho feta 50% ea kankere.
P53 Gene Etsa'ng?
Pene ea p53 e ikarabella bakeng sa liprotheine tse khonang ho lokisa lisele tse senyehileng kapa ho baka lisele tse senyehileng ho shoa, ts'ebetso e bitsoang apoptosis. Ha liphatsa tsa lefutso li sa sebetse ka lebaka la phetoho, liprotheine tsena tse lokisa lisele kapa tse felisang lisele tse senyehileng ha li hlahisoe, 'me lisele tse sa tloaelehang li lumelloa ho arola le ho hōla.
Tsela e bonolo haholo ea ho sheba liphatsa tsa lefutso tsa p53 e ka ba ho ipeha setšoantšo sa liphatsa tsa lefutso tsa p53, le plumber e le e 'ngoe ea liprotheine tseo u ka li laolang. Haeba u na le metsi a fokolang 'me u "sebetsana hantle," o tla khona ho letsetsa mohala oa plumber. Joale plumber e ka fihla lapeng la hao mme e lokisa lipompeta tse nang le leaky kapa e tlose ka ho feletseng ho emisa metsi a fokolang.
Haeba o ne o sa khone ho etsa pitso (e lumellanang le liphatsa tsa lefutso tse fosahetseng tsa p53), plumber e ne e ke ke ea bitsoa 'me ho phomola ho ne ho tla tsoelapele (ho tšoana le lisele tsa kankere tse arohaneng),' me qetellong moroallo o tla lula lapeng.
Ka mantsoe a mang, liphatsa tsa lefutso tsa p53 li sebetsa joaloka letlooa la tšireletso le thibelang lisele tse sa tloaelehang hore li se ke tsa fetoha li-tumor ka litsela tse tharo tse ka sehloohong (joalo-joalo ho na le lintho tse ngata tseo re li hlokang ho ithuta ka p53.) Ka:
- Ho fokotsa tšenyo ka DNA pele lisele tse senyehileng li arola ('me li fetise phoso.)
- E bakang apoptosis. Ha tšenyo ea DNA e le khōlō hoo e lokelang ho lokisoa, liphatsa tsa lefutso tse hlaselang likokoana-hloko li entse hore ho be le lefu la sele (apoptosis) e le hore tšenyo e se ke ea fetisoa.
- Ho ka 'na ha etsahala hore P53 e na le mesebetsi e mengata e mengata, ho akarelletsa le liphello tsa metabolism e phethang karolo ea bohlokoa ho hōla ha kankere.
Ke Eng e Bakang Tšenyo ho Gene P53?
Pene ea p53 e ka senyeha (e fetotsoe) ke lintho tse bakang kankere tikolohong , tse kang mosi oa koae . E ka boela ea ba sieo ho batho ba bang ho tloha tsoalong. Batho ba ruang phetoho e le 'ngoe feela ea liphatsa tsa lefutso tsa li-p53 (Li-Fraumeni syndrome) ba kentse ho ba le kankere hamorao bophelong.
Bohlokoa ba P53 Gene ka Kankere ea Lung
Tlhaloso ea liphatsa tsa lefutso tsa p53 le liprotheine tseo e li rutang li ka lebisa mekhoa e molemo ea ho hlahloba le ho phekola kankere ea matšoafo nakong e tlang.
Lisebelisoa:
Demirhan, O. et al. Mefuta e meng ea liphatsa tsa lefutso tsa p16 le p53 le likhetho tsa chromosomal ho bakuli ba nang le kankere ea matšoafo: Fluorescence in hy hyridization le lithuto tsa cytogenetic. Kankere ea Epidemiology . 2010 May 3. (Epub pele ea khatiso).
Farnebo, M. et al. P53 tumor supprossor: molaoli ea hloahloa oa mekhoa e sa tšoaneng ea lisele le lisosa tsa phekolo ea kankere. Likokoana-hloko le Lipatlisiso tsa Lipatlisiso tsa Likokoana-hloko . 2010. 396 (1): 85-9.
Hecht. S. Ts'ebetso le liphephetso libakeng tse khethiloeng tsa k'homphieutha ea koae. Lipatlisiso tsa lik'hemik'hale ho Toxicology . 2008. 21 (1): 160-71.
Ba bonolo, D. Tlhaloso ea karabo ea p53 le kamano ea eona le kankere. Journal of Biochemical Journal . 2015. 469 (3): 325-46.
Muller, P., le K. Youden. liphetoho tsa p53 tsa kankere. Cell Cell Biology . 2013. 15 (1): 2-8
Pfeifer, G. le A. Besaratinia. K'hatholike ea motho ea moloko oa batho. Human Genetics . 2009. 125 (5-6): 493-506.
Wang, X., Simpson, E., le K. Brown. p53: Tšireletso khahlanong le Khōlo ea Mokokotlo ho feta Metsoalle ea Selemo le Apoptosis. Patlisiso ea kankere . 2015 Nov 16. (Epub pele ea khatiso).