Balekane ba PARP ba ka phetha karolo efe kalafo ea kankere ea matsoele? Lithethefatsi tse 'maloa tse tsejoang e le PARP inhibitors li' nile tsa ithutoa morao tjena bakeng sa phekolo ea kankere ea matsoele. Sehlopha sena sa meriana se etsa'ng, hona se ka qetella se etsa'ng ho laola batho ba nang le kankere ea matsoele?
Mabapi le Phatlalatso ea PARP le DNA
PARP ke mantsoe a hlalosang polepole (ADP-ribose) polymerase.
PARP ke protheine e nang le likarolo tse 'maloa lits'ebetsong tsa cellular, haholo-holo ka ho lokisa DNA le ho shoa ha sele-cell (apoptosis). Lisele tse phetseng hantle li ka sebelisa PARP ho itokisa le ho phela bophelo ba tsona bo tloaelehileng. Empa lisele tsa kankere li ka boela tsa sebelisa PARP ho lokisa tšenyo ea DNA, ka tsela eo ho eketsa kholo ea bona e sa laoleheng. Lithethefatsi tse kang tsena li ka ba tse hanyetsanang le phekolo. Ho na le liprotheine tse fapaneng tsa PARP, 'me e mong le e mong o na le karolo ea hae mesebetsing ka har'a lisele.
PARP Inhibitors le Phekolo ea kankere ea matsoele
PARP inhibitor ke lithethefatsi tse thibelang liprotheine tsa PARP ho phetha karolo ea tsona ho lokisa lisele tsa kankere tse senyehileng. Chemotherapy le mosebetsi oa mahlaseli a kotsi ka ho roba DNA ea lisele e le hore li se ke tsa ikatisa. Mefuta e meng ea lisele tsa kankere e sebelisa li-enzyme tsa PARP ho lokisa tšenyo ea tsona ea DNA le ho hlaphoheloa ho hlaseloa ke kankere. Liteko tse 'maloa tsa kliniki li ntse li etsoa ho bona hore na PARP inhibitors, hammoho le mefuta e meng ea phekolo ea kankere, e ka thibela protheine ea PARP ho tloha lisele tsa kankere tse senyehileng.
Liphello Ka Lisele tsa Kankere ea Bokhachane
Haeba PARP inhibitor e ekelloa ka phekolo ea chemotherapy bakeng sa kankere ea matsoele, bafuputsi ba na le tšepo ea hore lisele tsa kankere tse hanelang lithethefatsi tsa meriana li tla ba kotsing ea tšenyo e bolaeang ea DNA. Maemong a mang, PARP inhibitor e ka sebelisoa e le mong , ho e-na le ho sebelisana le chemo le mahlaseli.
Litaba tse molemo haholo ke hore PARP inhibitors ha e bonahale e ama lisele tse tloaelehileng, tse se nang kankere. Seo se bolela hore ho na le litla-morao tse fokolang bakeng sa bakuli le ka potlako phekolo ea meriana.
Tšepo bakeng sa Kankere ea Kankere ea Botho
PARP inhibitors e ka ba e thusang haholo bakeng sa bakuli ba nang le kankere ea matsoele. Batho ba nang le BRCA1 le BRCA2 liphatsa tsa lefutso li fetohile kotsing e kholo ea ho hlahisa kankere ea matsoele. Liphatsa tsa 'mele tse phelang hantle tsa BRCA li hlahisa liprotheine tse ka thibelang ho thehoa ha mesifa ( li bitsoa likokoana-hloko tsa likokoana-hloko ), empa liphatsa tsa lefutso tsa BRCA ha li na matla ho etsa liprotheine tsena tse loantšang lisele tsa kankere. PARP inhibitors e ka sebelisa bofokoli bo nang le kankere ea kankere le BRCA e fetotsoeng. E 'ngoe e ka sebelisoang bakeng sa PARP inhibitors e ka ba thibelo ea kankere ea matsoele . Mohlomong PARP inhibitors e tla fetoha phekolo ea thibelo bakeng sa basali ba kotsing e kholo 'me e tla etsa hore maemo a se nang phihlelo a felisoe.
Ho Khothatsa Litaba tsa Kankere ea Bokhachane e sa Neng e Tšoaroang
Liteko tse 'maloa tsa lingaka tsa PARP inhibitors li fumane molemo o itseng oa tlhabollo ka ho eketsa phekolo ea PARP ho mekhoa e meng ea phekolo bakeng sa kankere ea maroana e bohloko ea matsoele . Liphuputsong tsena, PARP inhibitors e ne e mamella hantle. Ka nako ena phekolo e amohelehang feela bakeng sa kankere ea matsoele ea metastatic ke bevacizumab, empa lithethefatsi ena ha e na molemo o itseng ho batho ba tšoeroeng ke kankere ea matsoele e mararo.
Mesebetsi e meng ea PARP Inhibitors
Lithethefatsi tse entsoeng ka PARP inhibitors li ntse li lekoa ka mefuta e 'maloa ea kankere: matsoele le mae a bomme, uterine, boko, le pancreatic. Ka selemo sa 2015, PARP inhibitor e ile ea amoheloa bakeng sa phekolo ea kankere ea mae a mang.
Bohlokoa ba Bohlokoa ba likokoana-hloko tsa PARP
Ho tlatsetsoa ha PARP inhibitors ho sesosa sa morao-rao sa libetsa khahlanong le kankere ea matsoele se shebahala haholo. PARP inhibitors e eketsa katleho ea chemotherapy khahlanong le lik'hemik'hale tsa mafu tse nang le mahlaba a mahlano le a mararo, mohlomong ntle le ho eketsa litla-morao tse tebileng. Lithethefatsi tsena li bonahala li ntlafatsa boleng ba bophelo le ho atolosa bophelo ba bakuli.
Ho loantša kankere ea matsoele ka tekanyo ea DNA ea eona ho shebahala joaloka bokamoso ba bokamoso.
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