HER2 , e boetse e bitsoa HER2 / neu le HER-2, ke mantsoe a hlalosang motho epidermal kholo kholo receptor 2. Ho tseba boemo ba hau ba HER2 ke karolo ea bohlokoa ea ho hlahlojoa ha hao.
HER2 ke liphatsa tse hlahisang protheine tse teng ka holim'a lisele. Selefu e phetseng hantle ea matsoele e na le likopi tse peli tsa liphatsa tsa lefutso tsa HER2. Hoo e ka bang karolo ea 30 lekholong ea kankere ea matsoele, lisele tsa kankere ea matsoele li na le likopi tse fetang tse peli tsa liphatsa tsa lefutso, 'me sena se lebisa ho hlahisoeng ho feta ea protheine ea HER2.
Ka lebaka leo, lisele tse amehileng li hōla 'me li arola kapele haholo.
Ho buuoa ka ho feteletseng kapa ho hōlisa liphatsa tsa lefutso tsa HER2 ho bontšitsoe hore ho phetha karolo ea bohlokoa ho nts'etsopele le nts'etsopele ea mefuta e meng ea kankere ea matsoele le mefuta e meng ea kankere.
Na e Lefa?
Bothata bona ba lefutso ha bo futsane ho batsoali ba hao. Lintho tse sa tloaelehang tsa lefutso lena li amana le ts'ebetso ea kankere.
Liphello Tse Molemo le Tse Ntle Tsa Teko
Haeba kankere ea matsoele ea hao e lekoa bakeng sa boemo ba HER2, liphello li tla kenngoa ka mokhoa o nepahetseng kapa o fosahetseng. Haeba liphetho tsa hau li hlophisitsoe joaloka HER2 e ntle, seo se bolela hore liphatsa tsa hau tsa HER2 li fetile ho feta ho hlahisa protheine ea HER2. Haeba liphetho tsa hau li lefshoa HER2 e fosahetseng, joale liphatsa tsa HER2 ha lia hlakisoa.
Litlhare tse fumanehang
Herceptin (trastuzumab) ke moriana o sebelisoang ho tšoara kankere ea matsoele ea HER2 e ntle. Ke phekolo e thibelitsoeng mme e boetse e bitsoa kalafo ea mmele.
Lithethefatsi tsena li tla fuoa intravenously, hanngoe libeke tse peli ho isa ho tse tharo. Hang ha e le tsamaisong ea hau, Herceptin e hlasela liprotheine tsa HER2 tse nang le nomoro e fetang holim'a lisele tsa kankere ea matsoele. Sena se thusa ho emisa kholo ea lisele tsa kankere tse ntle tsa HER2.
Litholoana tse ling tsa phekolo ea Herceptin li kenyelletsa:
- e fokotsa li-tumor tse ntle tsa HER2, pele ho buuoa
- e felisa lisele tsa kankere tse ntle tsa HER2 tse jalileng ka nģ'ane ho hlahala ea pele.
- E thusa ho thibela ho khutlela morao (kananelo) ea kankere e ntle ea HER2
Liteko tsa HER2
Ngaka ea hau e ka 'na ea letsetsa liteko tse seng kae:
- FISH: Fluorescence In Situation Hybridization -llhahlobo ena e sebelisa lisebelisoa tsa fluorescent ho sheba palo ea likopi tsa liphatsa tsa lefutso tsa H22 ka selefouno. Haeba ho na le likopi tse fetang tse peli tsa lefu la HER2, joale kankere ke HER2 e ntle.
- IHC: ImmunoHistoChemistry -liteko ena e lekanyetsa tlhahiso ea protheine ea HER2 ka hlahala. Liphetho tsa liteko li hlahisoa e le 0, 1+, 2+, kapa 3+. Haeba liphetho li le 3+, kankere ea hau ke HER2-positive. Haeba liphello li le 2+, u tla hloka tlhahlobo ea FISH ho fumana hore na kankere ke ea HER2-positive.
The Bottom Line
HER2 kankere ea matsoele e ntle e fumanoa ke tlhahlobo ea IHC kapa FISH. Phello ea HER 2 e ntle ke ea bohlokoa, kaha e bontša hore kankere e ka phekoloa le Herceptin, hammoho le Perjeta le Kadcyla. Haeba kankere ea hau e fumanoa e le HER2 e ntle, e ka 'na ea e-ba e mabifi. Ho qala kalafo ka potlako ho tla thusa ho ntlafatsa pholoho ea hau, hammoho le thuso ea ho thibela pheta-pheto.