Mele ea rona e na le li-hormone tse laolang likarolo tsohle tsa metabolism, 'me tse kenyelletsang takatso ea lijo le taolo ea boima. Ho fumanoe li-hormone tse 'maloa tse amang takatso ea lijo le nts'etsopele kapa thibelo ea botenya . Ho na le li-hormone tse kholo tse 'nè: ghrelin , leptin, insulin le peptide YY (PYY). Sehlooho sena se bua ka leptin.
Leptin ke eng?
Ka mantsoe a bonolo feela, leptin ke hormone e sitisang takatso ea lijo.
E 'nile ea bitsoa "ntho e ts'oanelang" ka lebaka lena. Leptin e hlahisoa ke lisele tsa adipose (mafura). Ka hona, tekanyo ea tlhahiso ea eona e lekana le mafura a 'mele. Ha maemo a mafura a 'mele a eketseha, joalo ka leptin, e ntan'o sebeletsa ho thibela takatso ea lijo le ho eketsa tekanyo ea metabolism. Ha mafura a 'mele a oela, joalo ka leptin, le takatso ea lijo e tlosoa, ho bontša hore' mele ke nako ea ho ja hape. Qalong, sena se ne se sebeletsa morero oa ho thibela tlala.
Ka linako tse ling Leptin e nkoa e le molekane oa ghrelin hobane ghrelin (e 'ngoe ea lijo-thollo e laolang ka mpeng le ea duodenum) e etsa hore takatso ea lijo e eketsehe. Hobane leptin e ka fokotsa ho ja lijo ka ho thibela takatso ea lijo, e ka etsa hore ho be le boima ba 'mele; ho fapana le hoo, hobane ghrelin e ka eketsa ho ja lijo ka ho ba le takatso ea takatso ea lijo, e ka etsa hore boima bo be boima le botenya.
Ka 1994, liphatsa tsa lefutso tse hlahisang leptin, tse tsejoang e le liphatsa tsa lefutso tsa motho ( OB ), li ile tsa sibolloa ke Zhang le basebetsi-'moho le litoeba.
Leptin e tlalehiloe hore e na le mesebetsi e mengata ea likokoana-hloko, e akarelletsang likarabo tsa ho itšireletsa mafung le ho ruruha, karolo ea ho qaleha ha bokhachane, karolo ea ho thehoa ha masapo, le karolo ea ho folisa maqeba, har'a ba bang le ho phaella karolong ea eona ea taolo ea boima.
Ke'ng e Amehang Maemong a Leptin?
Bafuputsi ba fumane mekhoa e 'maloa ea boitšoaro le mabaka a ka eketsang kapa a fokotsa litekanyetso tsa leptin' meleng.
Ho bonahala lijo le boholo ba lijo li phetha karolo ea ho tlosoa ha leptin ho tloha mahlaheng a adipose. Ho feta moo, ho hlophisoa ha lijo ke habohlokoa. Ka mohlala, liphuputsong tse ling, lijo tse fokolang mafura li ne li bonahala li etsa hore ho be le liphallelo tse phahameng ho feta lijo tse phahameng haholo. Hape ho na le bopaki ba hore bakuli ba bangata ba fetohile leptin-resistant, kapa ba hanyetsana le liphello tsa leptin, kahoo tsela e tloaelehileng ea tsamaiso ea likokoana-hloko e bolellang 'mele ha nako ea ho khaotsa ho ja e ferekane.
Ho robala hanyenyane haholo ho ka boela ha ama leptin, e leng se fellang ka maemo a fokolang le takatso e khōlō ea ho sebetsa (ho sebetsa hammoho le ghrelin, joalokaha ho boletsoe ka holimo). Ho fumana lihora tse supileng ho isa ho tse robong tsa boroko bo sa tsitsang bosiu bo bong le bo bong ho bonahala ho thusa ho boloka litekanyetso tsa leptin moo li lokelang ho ba teng ha li arajoa.
Joalokaha ho ka 'na ha nahanoa, ka lebaka la bokhoni ba eona ba ho senya boima ba' mele, lithuto li shebile litsela tse fapaneng tsa ho sebelisa leptin le mesebetsi ea eona ea phekolo ea pharmacologic e 'nile ea tsoela pele ka nako e itseng' me e le karolo ea ho tsoela pele ho batlisisa mekhoa e atlehileng ea ho phekola botenya.
Lisebelisoa :
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