Isentress (ratelgravir) ke motsoako oa integrase -hibitla -mafu o sebelisoang ho phekola tšoaetso ea HIV . Isentress e bile setsi sa pele sa integrase inhibitor se amoheloang ke US Food and Drug Administration (FDA).
Ka October 2007, e ne e lumelloa ho sebelisoa ho batho ba baholo ba neng ba e-na le lithethefatsi tse ling tsa li-antiretroviral . Empa ka July 2009, 'me hamorao ka December 2011, FDA e ekelitse pontšo ea eona, e lumella ho sebelisoa ho batho bohle ba baholo ba nang le HIV, hammoho le bana ba lilemo li 2-18.
Isentress ke e 'ngoe ea lithethefatsi tseo hona joale li khothalletsoang hore e be khetho ea pele ea linea bakeng sa phekolo ea HIV ho US
Formulations
Isentress e teng ka mekhoa e mene e sa tšoaneng:
- Bakeng sa batho ba baholo le bana ba baholo, Isentress e fumaneha e le letlapa le koahetsoeng ka filimi e 400mg, e oval ka sebōpeho le pinki-ea bohloa. Nomoro "207" e pota-potiloe ka lehlakoreng le leng.
- Bakeng sa bana ba sa khoneng ho nka matlapa, Isentress e fumaneha e le 100mg e tsitsitseng (oval, beige, embossed ka lehlakoreng le leng le "477," e fumanoeng ka ho arohana) kapa 25mg chewable (pale e mosehla, e pota-potiloeng ka mahlakore ka lehlakoreng le leng "473 "). Ka bobeli li-orange-banana li monate.
- Bakeng sa bana ba banyenyane ba sitoang ho nka mekhoa e metle, Isentress e fumaneha ka pakete e le nngwe, 100mg ho emisoa molomo. Ho emisoa ha molomo ho kopane le metsi a 5mL 'me ho tsamaisoa ka seringe ea molomo. Hang ha e kopane, ho lokisoa ka molomo ho lokela ho sebelisoa ka metsotso e 30, 'me ho setseng ho le joalo ho lahlehe hang-hang. Ho emisoa ke banana ba khethiloeng.
Le ka mohla u se ke ua nkela li-isentress li-jowable kapa ho emisa molomo bakeng sa lipilisi tse koahetsoeng ka filimi ea Isentress kaha li-formulation ha li bioequivalent. Sebelisa feela kamoo ho laetsoeng kateng (sheba Lintlha tse ka tlase).
Dosages
Isentress 400mg, matlapa a koahetsoeng ka filimi a lokela ho laeloa bakeng sa batho ba baholo le bana ba baholo ba khonang ho metha matlapa, ka tsela e latelang:
- Batho ba baholo: tekete e le 400mg, e nkiloeng habeli ka letsatsi
- Bakeng sa bana kapa bacha ba boima ba lik'hilograma tse 25 (25kg) kapa ho feta: tekete e le 400mg, e nkiloeng habeli ka letsatsi
Lipilisi tse chewaable tsa Isentress li lokela ho ngolloa ho bana ba boima ba lik'hilograma tse 20 kapa ho feta ba sitoang ho matlafatsa matlapa, ka tsela e latelang:
- Ho boima ba lik'hilograma tse 20 ho ea ho lik'hilograma tse 28: 150mg habeli ka letsatsi
- Lik'hilograma tse 28 ho ea ho lik'hilograma tse 40: 200mg habeli ka letsatsi
- Ho feta lik'hilograma tse 40: 300mg habeli ka letsatsi
Ho qobelloa ka molomo oa Isentress kapa matlapa a tsitsitseng a lokela ho laeloa bakeng sa bana ba boima ba lik'hilograma tse 3 lik'hilograma tse 25kg, ka tsela e latelang:
- Ho na le lik'hilograma tse 3 lik'hilograma tse 4kg: 1mL (20mg) e lokiselitsoeng ho emisoa molomo ka makhetlo a mabeli letsatsi le letsatsi
- 8 lik'hilograma (4kg) ho ea ho lik'hilograma tse 6: 1.5mL (30mg) e lokiselitsoe ho emisa molomo ka makhetlo a mabeli letsatsi le letsatsi
- Lik'hilograma tse 6 ho ea ho lik'hilograma tse 8kg: 2mL (40mg) ho lokiselitsoe ho emisa molomo ka makhetlo a mabeli letsatsi le leng le le leng
- Lik'hilograma tse 8 ho ea ho lik'hilograma tse 11: 3mL (60mg) ho lokiselitsoe ho emisoa ka molomo habeli ho nkoa habeli ka letsatsi
- Lik'hilograma tse 11 ho ea ho lik'hilograma tse 14 (4kL): 4mL (80kg) e lokiselitsoe ho emisoa ka molomo habeli ha letsatsi le leng le le leng OR matla a 75mg a nooang habeli a letsatsi ka leng
- Lik'hilograma tse 14 ho ea ho lik'hilograma tse 20: 5mL (100kg) ho lokiselitsoe ho emisoa ka molomo habeli ha letsatsi le leng le le leng OR matla a 100mg a noa a nkiloeng habeli ka letsatsi
Tsamaiso ea lithethefatsi
Isentress e ka nkoa ka ntle kapa ntle le lijo. Isentress e ke ke ea nkoa e le 'ngoe' me e tlameha ho behoa e le karolo ea motsoako oa antiretroviral (pampiri) .
Liphello tse Tloaelehileng
Litla-morao tse tloaelehileng ka ho fetisisa (tse hlahang ka 2% kapa tse ka tlaase ho linyeoe) ke:
- Ho tsieleha
- Hlooho ea hlooho
- Sehlōhō
- Nausea
- Mokhathala
Litlhōlisano
Ha ho letho
Litšebelisano le lithethefatsi
Ka kopo o tsebisa ngaka ea hau haeba u noa meriana e latelang ha e sa khothalletsoa ho tsamaisana le Isentress 'me e ka kena-kenana le bothata ba lithethefatsi:
- Li-antibiotics tse thehiloeng Rifampin: Rifadan, Rifater, Rifamate, Rimactane
- Li-antacids tse thehiloeng ho aluminium kapa li-magnesium (mohlala, Li-Tums, Lebese la Magnesia, joalo-joalo)
Tlhokomelo
Bakuli ba nang le bothata ha ba qalile Isentress ba lokela ho iteanya le ngaka hang-hang. Kalafo e lokela ho emisoa 'me phekolo ea meriana e batlehe haeba lebelo le tsamaisana le feberu, mesifa kapa maqeba a kopantsoeng, marabele kapa liso, ho khubelu kapa ho ruruha ha mahlo, ho ruruha ha sefahleho kapa molomo, kapa mathata a phefumoloho. Bakuli bao pele ba neng ba e-na le tšebetso ea hypersensitive ho Isentress ha baa lokela ho tsosoa hape ka lithethefatsi ka mor'a ho rarolla matšoao.
Lipatlisiso tsa liphoofolo ha li bontše bokooa ba masea kapa bokhachane nakong ea bokhachane ho litoeba kapa mebutlanyana tse pepesehileng ho Isentress. Leha ho le joalo, tšusumetso ea Isentress ho masea a nang le matsoele ha a e-s'o thehoe, 'me ka lebaka leo, ho anyesa ha ho khothalletsoe hore bo-'mè ba nke Isentress.
Lisebelisoa:
Lefapha la Bophelo le Litšebeletso tsa Botho (DHHS). "Tataiso ea Tšebeliso ea Basebetsi ba Antiretroviral bathong ba nang le HIV-1-ba nang le tšoaetso le bacha." Rockville, Maryland.
FDA. "FDA e Hlakisa Tšebeliso ea Setlhare sa Meriana ea HIV ho Bana le Bacha." Silver Spring, Maryland; La 21 December, 2011.
Reuters. "SEHLOOHO sa 2-FDA OKs se sebelisoa haholoanyane ka Merck's Isentress HIV Meriana." La 9 July, 2009.
US Administration of Drug and Drug Administration (FDA). "Phaketeng ea Tšebeliso ea Lithethefatsi - Lebitso la Meriana: Isentress (ratelgravir) Matlapa a 400mg." Silver Spring, Maryland; La 12 October, 2007.