Benfotiamine ke mofuta o entsoeng ke batho oa thiamine kapa B1. Thiamine ke vithamine e qhibilihang ka metsi 'me kahoo ha e sebelisoe habonolo ke' mele. Benfotiamine ke sebopeho se nang le mafura 'me se ntlafatsoa le ho sebelisoa. Ho 'nile ha e-ba le bopaki ba hore benfotiamine e ka thusa ho felisa bothata ba lefu la tsoekere joaloka retinopathy, nephropathy, le neuropathy.
- Bothata ba lefu la tsoekere ke eng?
- Ke lefu la tsoekere la Nephropathy?
- Sehlopha sa lefu la tsoekere ke eng?
Benfotiamine bakeng sa Diabetes Neuropathy
Benfotiamine e entsoe lithuto tse 'maloa lilemong tsa morao tjena. Sepheo se seholo sa liphuputso se kenyelletsa ho sebelisa benfotiamine e le phekolo ea mathata a lefu la tsoekere.
Mathata a mangata a tsoekere a bakoa ke lefu la tsoekere le phahameng ka nako e telele ka lebaka la tšelo ea mali e sa laoleheng kapa ho feta ha nako e ntse e feta. Ho ba le tsoekere e feteletseng maling ho kenngoa lisele tsa methapo le methapo e nyenyane ea mali ea lipheletsong, ho baka tšenyo libakeng tsena tse hlahisang matšoao le matšoao a mathata.
Litsela Tse 'nè tsa Tlokotsi ea Lisele
Ho na le litsela tse 'nè tse fapaneng tse hlahang' meleng o ka lebisang tšenyo e nyenyane ea lisebelisoa tsa mali ka lebaka la hyperglycemia le lefu la tsoekere.
- Li-endproducts tse tsoetseng pele tsa li-glycation (AGE)
- Protein kinase C (PKC)
- Hexosamine tsela ea activation
- Tsela ea polelo ea Polyol
Benfotiamine e bonahala e thibela litsela tse tharo tsa lithuto tsa bongaka. Sehlooho se hlahang koranteng ea Nature Medicine ka February 2003, se bitsoang "Benfotiamine Blocks Three Major Ways of Hyperglycemic Damage 'me se thibela ho hlahloba lefu la tsoekere la lefu la tsoekere" se bontšitse hore benfotiamine e ile ea thibela lefu la tsoekere la lefu la tsoekere liphoofolong tsa laboratori.
Lihlahisoa tse qetellang tsa Glycation End
Hyperglycemia e baka tšenyo meleng ea mali le methapo ea 'mele, e leng eona e fetohang mathata a maholo a lefu la tsoekere. Tšenyo e etsahala ha khase e feteletseng ea mali e kenella ka liseleng ebe e etsa ntho e tsejoang e le li-endproducts tse tsoetseng pele tsa li-glycation. LILEMO li fumanoa lijaneng tsa mahlo, liphio le lipheletsong. Li boetse li fumanoa meleng e meng ea methapo ea mali mme li lebisa ho sebopeho sa plaque le atherosclerosis, e tlatsetsang ho lefu la pelo.
Seo Benfotiamine e se Etsang
Liphuputso li bontšitse hore benfotiamine e bonahala e thusa ho thibela mathata a lefu la pelo, lefu la retinopathy, le nephropathy ka ho thibela ho haha ha tsoekere lijaneng. Sena se bolela hore ho ba teng ha mathata a tsoekere ho ka 'na ha lieha kapa ho thibeloa. Phuputso ea bongaka e ileng ea hlaha koranteng ea ADA ea Diabetes ka 2003 e bontšitse hore thiamine e phahameng le thibelo ea benfotiamine e ne e bonahala e thibela microalbuminuria le proteinuria (liprotheine mouteng) likokoanyana tsa tsoekere. Lithuto tse entsoeng ho batho li bontšitse hore benfotiamine e bonahala e boetse e kokobetsa bohloko ba pelo.
Boemo ba Hona joale ba Benfotiamine
Benfotiamine e ntse e le mohato oa teko ea meriana. Hangata liphuputso li entsoe ka likhoto tse 'nileng tsa susumelletseha ho ba le lefu la tsoekere.
Liteko tse matla haholo li hlokahala ho fumana hore na benfotiamine e sebetsa ka tsela e ts'oanang le batho ba nang le lefu la tsoekere. Litekanyetso tse atlehang ha lia lokela ho thehoa, 'me litla-morao tsa nako e telele ha li tsejoe.
Le hoja benfotiamine e sa khothaletsoe ka molao ke litsebi tsa bophelo bo botle ba Amerika nakong ena, ho bonahala eka e ka ba phekolo e tšepisang ea mathata a tsoekere tlas'a tsela.
Kamohelo e ntse e emetsoe ke FDA
Tsamaiso ea Tsamaiso ea Lijo le Lithethefatsi (FDA) ha e e-s'o amohele benfotiamine bakeng sa tšebeliso ea sechaba. Ho na le likhohlano mabapi le hore na motsoako ona o lokela ho ngoloa joang, ebang ke motsoako oa lijo kapa vithamine.
Ho na le lintho tse amehileng ka polokeho e akaretsang ea tšebeliso ea nako e telele ea benfotiamine le hore na ke tekanyo efe e sireletsehileng. FDA e hloka bopaki bo bongata ba hore benfotiamine e hlahisa liphello tse bonngoeng litsing.
Selemong se fetileng, benfotiamine e ile ea kenngoa ho FDA e le tlatsetso ea lijo, empa tumello e ntse e emetse ka nako ena.
- Lethathamo la FDA Lengolo la ho Araba ea Benfotiamine e le Tlatsetso ea Lijo
Lisebelisoa:
> Haupt, E., Lederman H., Kopcke W. "Benfotiamine ho Phekolo ea Diabetic Polyneuropathy - Kemiso e 'Ngoe ea Boraro e Fetotsoeng, Leihlo la Tlhahlobo e laoloang." International Journal of Clinical Pharmacology, Therapy le Toxicology Jun 2005: 304. PubMed.gov. Laebrari ea Sechaba ea Meriana le Mekhatlo ea Sechaba ea Bophelo. 09 Mar 2007.
> Huebschmann, MD, Amy G., Regensteiner, Ph.D., Judith G., Vlassara, MD, Helen, le Reusch, MD, Jane EB "Lefu la tsoekere le Lihlahisoa tsa ho qetela tsa Glycoxidation." Tlhokomelo ea lefu la tsoekere ka 2006 1420-1432. 09 Mar 2007.
> Melpomemi >, MD, Peppa, Uribarri, MD, Jaime, le Vlassara, MD, Helen. "Glucose, Lihlahisoa tse Phahameng tsa Glycation End, le Mathata a Ts'oaetsong: Ke Eng e Ncha le e Sebetsang." Meriana ea lefu la tsoekere 2003 186-187. 09 Mar 2007.
>>>>>>>,>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> , MD, Michaela, Koschinsky, MD, Theodor, Uribarri, MD, Jaime, Vlassara, MD, Helen le Tschoepe, MD, Diethelm, "Benfotiamine e Thibela Mathata a Macro-le Microvascular Endothelial Dysfunction le Khatello ea Kelello ea Khatello ea Kelello Ka mor'a ho ja Lijo Tse Phahameng Lihlahisoa Tse Phahameng ka Glycation ho Batho ba nang le Mofuta oa 2 oa Lefu la tsoekere. " Tlhokomelo ea lefu la tsoekere 2006 2064-2071. 13 Mar 2007.
> "Lithethefatsi ho Tšoara Likotsi." Ho Fuputsoa ho ea Sebele. 2005. Mokhatlo oa Machaba oa Ts'oaetso oa lefu la tsoekere oa Machaba. 18 Mar 2007.
> Hammes, Hans-Peter, Xueliang Du, Diane Edelstein, Tetsuya Taguchi, Takeshi Matsumura, Qida Ju, Jihong Lin, Angelika Bierhaus, Peter Nawroth, Dieter Hannak, Michael Neumaier, Regine Bergfeld, Ida Giardino, Michael Brownlee. "Li-Blofo tsa Benfotiamine Mekhoa e Mehlano e Meholo ea Tšenyo ea Hyperglycemic le ho thibela ho hlahloba lefu la tsoekere la Diabetes." Nature Medicine, 18 Feb. 2003 294-299. 18 Mar 2007.