Liphello tsa pele ho Meriana e Lebelloang CGRP le Moeletsi oa eona
Peptide e amanang le liphatsa tsa lefutso (CGRP) ea Calcitonin, protheine e hlahisoang ke lisele tse ling tsa methapo ea methapo ea methapo ea methapo ea methapo le methapo ea methapo ea methapo, e lumeloa hore e phetha karolo ea bohlokoa ho migraine. Hase feela hore protheine e fumaneha nakong ea tlhaselo ea migraine, empa ho fokotsa bohloko ba migraine ka meriana ea migraine e bitsoang triptan e lumellane le ho tloaeleha ha maemo a CGRP maling.
Nakong ea tlhaselo ea migraine, ho ka 'na ha etsahala hore litlhaselo tse itseng tsa migraine li susumelletsa methapo ea mali ho pota-potile, kapa e atolose. Tsena methapo ea mali e tsoekere e ntan'o etsa hore ho be le metsoako ea methapo ea methapo ea trigeminal. Hang ha e ts'ebetsoe, li-trigeminal nerve fibers li romela bohloko ba boko - e leng se etsang hore ho lokolloe liprotheine tse sa tšoaneng, joaloka CGRP.
CGRP e ntan'o etsa hore ho be le ho eketseha ha methapo ea mali le ntho e bitsoang "ho ruruha ha neurogenic". Ha litlhaselo tsa migraine li ntse li tsoela pele, bokhoni ba kelello bo fetoha. Sena se lebisa kotsing e sehlōhō ea bohloko ba hlooho le ho ba le kutloisiso e eketsehileng tikolohong ea motho.
Lithuto tsa Pele li etsoa joang ka CGRP?
Lithuto tsa Phase II - liphuputso tse entsoeng ka lenane le lenyenyane la bakuli ho fumana hore na lithethefatsi li na le liphello life le tse ka hlahang ho fihlela joale li fana ka tlhahiso ea hore li-antibodies tsa CGRP li thibele migraine 'me li mamelloe hantle.
Phuputsong e le 'ngoe, barupeluoa ba 217 ba fumanoang ka makhetlo a mane ho isa ho a mane ka khoeli, ba ne ba sa hlokomeloe ka sekhukhu hore ba fumane ka tlas'a liente tsa letlalo ka makhetlo a mabeli beke le beke ea lithethefatsi tse bitsoang LY2951742 kapa placebo - e leng tsoekere kapa metsi a kenang libeke tse 12.
(LY2951742 ke antibody ho peptide e amanang le liphatsa tsa lefutso (CGRP) - sena se bolela hore e tlama ho CGRP mme e e thibela kapa e e thibela).
Liphello li ile tsa bontša hore barupeluoa ba amohetseng LY2951742 ba fokotsehile haholo palo ea matsatsi a bona a hlooho ea hlooho ea migraine ha ba bapisoa le placebo. Litaba tse monate hape ke hore moriana ona o fumanoe o sireletsehile mme o mamelloa hantle ke lihlooho.
Ho boleloa hore liphello tse bohloko li kenyeletsa:
- bohloko ba mahlaba a ente
- bohloko ba mpeng
- pheko ea tšoaetso e phahameng (mohlala, bronchitis)
Moriana o mong o bitsoang ALD403 - hape o hlahlojoa ke batho ba 163 ba nang le phihlelo ea 5 ho isa ho e 14 khoeli ka khoeli. Karolo e 'ngoe ea lihlooho li amoheloa ka sekhukhu ka 1000mg e se nang methapo (ka methapo) tekanyo ea lithethefatsi, ha halofo e' ngoe e fumana sebaka sa placebo. Litaba li ile tsa lateloa likhoeli tse 6.
Nakong ea libeke tse 5 ho ea ho tse 8, barupeluoa ba fumaneng lithethefatsi ba bone ts'oaetso ea 66 lekholong matsatsing a matsatsi ao ba ileng ba ba le bothata ba migraine le liphesente tse 52 bakeng sa ba amohetseng placebo.
Hape, libeke tse 12, bakuli ba 16 lekholong ba fumaneng lithethefatsi ba ne ba se na bolokolohi ba migraine ka ho feletseng ho ba amohetseng placebo.
Qetellong, lithethefatsi tse ling, tse tsamaisoang ka tlas'a letlalo (injection subcutaneous) e bitsoang AMG 334 - e leng antibody e tlamang mofuthu oa CGRP (sebaka sa ho etela sekolo sa CGRP) - sa sa tsoa fumanoa ho thibela migraine hape. Joaloka lithethefatsi tse ling tse peli, AMG 334 e ne e mamella hantle. Liphetho tse bohloko ka ho fetisisa li ne li le:
- matšoao a batang
- mokhathala
- hlooho kapa migraine (ho ea setšoantšo - se senyenyane haholo, karolo ea 3 ho ea ho 1 lekholong sehlopha sa placebo)
- ho nyekeloa ke pelo
- pheko ea tšoaetso e phahameng (mohlala, bronchitis).
The Bottom Line
Ka sebele tsena ke liphello tse thabisang ho sechaba sa migraine. Leha ho le joalo, thuto e kholoanyane ea bo-III - lithuto tse kholoanyane le ho netefatsa lipolelo tsa lipatlisiso tsa phalliso ea II - li lokela ho etsoa pele meriana ena e tla fumanoa ho bakuli.
Lisebelisoa:
Bigal ME, Walter S, Rapoport AM. Lihlahisoa tsa Calcitonin li tlalehile peptide (CGRP) le kutloisiso ea hona joale ea migraine le boemo ba tsoelo-pele. Hlooho ea hlooho . 2013; 53 (8): 1230-44.
Durham PL. Calcitonin Gene-Related Related Peptide (CGRP) le Migraine. Hlooho ea hlooho. 2006; 46 (Tlatsetso ea 1): S3-S8.
Goadsby PJ, & Edvinsson L. Ts'ebetso ea trigeminovascular le migraine: lithuto tse bontšang liphetoho tse se nang mokokotlo le li-neuropeptide tse bonoang ho batho le likatse. Ann Neurol. 1993 Jan; 33 (1): 48-56.
Liphello tsa pele bakeng sa ALD403, Phetoho e ncha ea Investigational bakeng sa Thibelo ea Migraine. (nd). Mokhatlo oa Mahloa-hlooho oa Amerika. E khutlisitsoe ka la 18 Mantaha, 2014.
Sun H et al. Tšireletseho le katleho ea AMG 334 bakeng sa thibelo ea migraine ea mahlomola: tlhahlobo ea bobeli ea bobeli, e bobeli, e bofubelu, e nang le bobeli bo sebetsanang le placebo. Lancet Neurol. 2016; 15 (4): 382-90.