Mokhathala ke e 'ngoe ea matšoao a tloaelehileng a Multiple Sclerosis (MS) ,' me e ka ba e fokolisang haholo le e boima-ka linako tse ling esita le ho feta matšoao a bona a MS, joaloka mathata a mesifa kapa mathata a tekanyo.
Ntle le ho holofala, mokhathala o amanang le MS ke letšoao le qhekellang haholo ho phekola. Le hoja Provigil (modafinil) le Symmetrel (amantadine) hangata li laeloa bakeng sa mokhathala oa MS, ha ho na bopaki bo bongata ba saense bo tšehetsang tšebeliso ea bona.
Hape, meriana ena e na le litla-morao tse sa rateheng. Ka mohlala, Provigil (modafinil) e ka baka boroko, e ka senyang mokhathala oa motho. Ak'u nahane u se u le bosiu bohle-sena se tla tsoela pele ho ntlafatsa, eseng ho thusa, ho khathala ha hao.
Kahoo boholo ba litsebi tsa MS (le batho ba phelang le MS) ba batla ka potlako tharollo ea ho loantša mokhathala oa MS. Le hoja mekhoa ea bophelo ea bophelo e kang ho ikoetlisa e bontšitse tšepiso, ba bangata ba boetse ba batla "pilisi e loantšang mokhathala."
Coenzyme Q10
Coenzyme Q10 , e tsejoang hape e le CoQ10, ke antioxidant e fumanehang hoo e batlang e le sele e 'ngoe le e' ngoe 'meleng oa hau. E le antioxidant, ha e amohele li-radicals tsa mahala, tse ka senyang lisele tsa 'meleng oa hau. Ka ho loantša li-radicals tse sa lefelloeng, coenzyme Q10 e lumeloa hore li boloka lisele li phetse hantle, li ntlafatsa ts'ebetso ea tsona le matla a metabolism.
Coenzyme Q10 e boetse e lumeloa hore e na le lintho tse khahlanong le ho ruruha. Sena se bolela hore se ka kokobetsa tsamaiso ea 'mele ea motho ea ho itšireletsa mafung, eo re e tsebang e sebetsa ho feta motho ea nang le MS.
Ha e le hantle, lipatlisiso li bontšitse hore tlatsetso ea coenzyme Q10 e theola likarolo tse itseng tsa ho ruruha, joaloka tumor necrosis factor (TNF) , maling.
Ka hona, na phaello e kang coenzyme Q10 e ka fokotsa mokhathala oa moratuoa oa hau oa moratuoa oa hau? Ho latela phuputso e 'ngoe ho ka' na ha e-ba molemo hore u leke. Hore ho boleloa, etsa bonnete ba hore u buisane le lingaka leha e le life tse ncha kapa meriana pele u etsa bonnete ba hore u bolokehile.
Ho Tšoara Mokhathala oa MS le Coenzyme Q10
Phuputsong ea 2016 ho Nutritional Neuroscience, barupeluoa ba 45 ba nang le multiple sclerosis ba ile ba fumana li-500mg tsa coenzyme Q10 kapa pilisi ea placebo letsatsi le leng le le leng bakeng sa libeke tse 12. Thuto ena e ne e foufalitsoe ka makhetlo a mabeli, ho bolela hore ha ho barupeluoa kapa bafuputsi ba tsebang hore na ba fumane coenzyme Q10 hokae ba amohetseng pilisi ea placebo.
Qalong ea thuto, tekanyo e atisang ho sebelisoa ho lekanyetsa mokhathala MS (e bitsoang Mokhathala oa Sekhahla sa Matšoafo) e ne e tsamaisoa ho bohle ba kenang thupelong. E ne e tsamaisoa hape qetellong ea thuto (libeke tse 12).
Bothata ba ho ba le khatello ea mokhathala (FSS) bo na le lipolelo tse robong tse fumanoang ka tekanyo ea lintlha tse supileng, ka moelelo o le mong "o sa lumellane ka matla" le tse supileng tse bolelang "ho lumellana haholo." Palo ea kakaretso ke karolelano ea linomoro tsena tse robong, tse nang le lintlha tse phahameng tse bontšang mokhathala o matla haholo.
Mantsoe a mohlala ho tloha tekanyong ke "mokhathala o sitisa mosebetsi oa ka, lelapa, kapa bophelo ba kahisano." Haeba o lumellane ka matla le polelo ena, o tla fumana lintlha tse 7 (lintlha tse phahameng).
Liphello tsa phuputso li fumane hore barupeluoa ba neng ba nka coenzyme Q10 ba ne ba fokotseha haholo ts'ebetsong ea bona ea FSS-sena se bolela ho khathala ho fokolang-ha ho bapisoa le barupeluoa ba nkileng pilisi ea placebo.
Ho Phekola Matšoao a Tšoenyehang MS le Coenzyme Q10
Thuputsong e le 'ngoe, bohle ba kenang lihlopha ba ile ba hlahlojoa hape bakeng sa matšoao a ho tepella maikutlo ho sebelisa Beck Depression Inventory (BDI).
BDI e na le lipotso tse mashome a mabeli a metso e 'meli tse khethiloeng ka bongata tseo e mong le e mong a li fumaneng ho tloha ho zero ho ea ho tse tharo,' me tse tharo li emela matšoao a matla haholo. Mehlala ea matšoao a tepeletseng a hlalositsoeng tlhahlobo ena a kenyeletsa:
- maikutlo a ho hlomoha, ho hloka tšepo, ho nyahama, ho ikutloa molato, le / kapa ho halefa
- matšoao a 'mele joaloka ho lahleheloa ke boima, ho khathala, ho lahleheloa ke thahasello tabeng ea ho kopanela liphate le ho lahleheloa ke takatso
- maikutlo a ipolaeang
Qetellong ea thuto, barupeluoa ba neng ba nka coenzyme Q10 ba ile ba ntlafatsa haholo matšoao a bona a tepeletseng, ha ba bapisoa le litho tsa sehlopha tse ileng tsa nka pilisi ea placebo.
Se Boleloang ke Liphello Tsa ho Ithuta
Liphello li bontša hore coenzyme Q10 e thusa ho fokotsa khatello le matšoao a tepeletseng ho barupeluoa ba nang le MS. Ena ke maikutlo a thabisang, haholo-holo kaha coenzyme Q10 e fumaneha ka holimo-le-counter.
E boetse e na le boemo bo tlaase ba phello, e nang le litla-morao tse tloaelehileng ho akarelletsa:
- 'mele oa halefa
- ho nyekeloa ke pelo
- letšollo
- rash
- hlooho
Coenzyme Q10 e fumaneha ka litsela tse 'maloa tse akarelletsang li-capsules tse bonolo le tse thata, matlapa a lipilisi, esita le ho hlahisa molomo.
Sena sohle se boleloa, thuto e ne e le nyenyane (e leng barupeluoa ba 45 feela) 'me e nka libeke tse 12. Lipatlisiso tse kholo le tsa nako e telele li hlahloba liphello tsa coenzyme Q10 ho batho ba nang le MS ba lokelang ho etsoa.
Hape ke habohlokoa ho utloisisa hore Coenzyme Q10 ha e amohelehe ke US Food and Drug Administration (FDA) bakeng sa ho phekola boemo leha e le bofe ba bongaka, ho akarelletsa le mokhathala MS.
Batla Tataiso e tsoang ho Ngaka ea hau
Le hoja coenzyme Q10 ke tlatsetso mme e fumaneha ntle le lengolo la ngaka, e lokela ho nkoa feela tlas'a tlhokomelo ea ngaka, haholo-holo kaha e ka 'na ea se ke ea nepahala bakeng sa motho e mong le e mong.
Ka mohlala, ho batho ba bang, coenzyme Q10 e ka fokotsa tsoekere ea mali. Sena se ka 'na sa e-ba bothata ho batho ba nang le lefu la tsoekere ba ntseng ba noa meriana e fokolang tsoekere ea mali.
E ka boela ea kopana le meriana e meng e kang meriana ea khatello ea mali kapa meriana e fokolang mali. Kahoo le haeba ngaka ea hao e u fa ho loketse ho leka coenzyme Q10, u ka 'na ua hloka tlhokomelo e khethehileng.
Hape, litekanyo tse sebelisoang thutong ena li phahametse ka 500mg ka letsatsi. Likotlolo tse ngata tsa tlatsetso li re ha li nke ho feta 200mg ka letsatsi. Haeba o tla leka tlatsetso ena, netefatsa tekanyo e nepahetseng le ngaka ea hau. Ka mohlala, ho sebelisa tekanyo e fokolang haholo ho ka 'na ha e-ba ka tlase ho phekoloa (ka mantsoe a mang, ho sa fe monyetla oa ho tlatsetsa monyetla oa ho u thusa).
Peek In Future of Coenzyme Q10 ka Multiple Sclerosis
Coenzyme Q10 ha e e-s'o hlahlojoe haholo ka multiple sclerosis, empa sena se ka fetoha.
Ha e le hantle, phuputso e tšehetsoeng ke National Institute of Neurological Disorders le Stroke e hlahloba liphello tsa lithethefatsi tse bitsoang Idebenon-lithethefatsi tse entsoeng ke batho tse tšoanang le coenzyme Q10. Thuto e hlahloba ts'ireletso le katleho ea Idebenone ho phekola batho ba nang le MS e tsoelang pele-pele .
Phuputso ena e bapisa ka tekanyo ea tekanyo ea tsoelo-pele ea boko ba atrophy (ho fokotseha ha boko ho tloha ho lahleheloa ke lisele tsa methapo) ho batho ba nkang Idebenone ho batho ba nkang sebaka sa placebo.
Phuputso ena ke phuputso ea Phase I / II, kahoo haholo-holo, empa e thabisang leha ho le joalo-haholo-holo ha hona joale ha ho na meriana e amohelehang ea FDA bakeng sa ho phekola MS e tsoetseng pele.
Lentsoe le Tsoang ho
Le hoja lipatlisiso tse ngata tsa saense li lokela ho etsoa ka ts'ireletso le molemo oa ho nka coenzyme Q10 bakeng sa ho phekola matšoao a MS joaloka mokhathala, kapa esita le lefu ka boeona, thuto ena ea 2016 ho Nutritional Neuroscience ke qalo e ntle.
> Mehloli:
> Mezawa M et al. Mofuta o fokolitsoeng oa coenzyme Q10 o ntlafatsa ho laola glycemic ho bakuli ba nang le lefu la tsoekere la mofuta oa 2: thuto ea lifofane e bulehileng. Li-biofactors . 2012 Nov-Dec; 38 (6): 416-21.
> Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 e le phekolo ea mokhathala le ho tepella maikutlong ho bakuli ba bangata ba lefu lena: Tlhahlobo e 'meli ea bokooa e entsoeng ka mahlaseli a mabeli. Nutritional Neurosci . 2016; 19 (3): 138-43.
> Sanoobar M et al. Coenzyme Q10 tlatsetso e ntlafatsa matšoao a ho ruruha ho bakuli ba nang le multiple sclerosis: bokofu bo habeli, placebo, teko e laoloang ke lingaka. Nutritional Neurosci. 2015 May; 18 (4): 169-76.
> Mokhatlo oa Bongaka oa Maryland oa Maryland. (January 2015). Coenzyme Q10.
> Li-Institutes tsa Bophelo tsa US. (October 2016). Phaputso ea bobeli ba sebaka se nang le bokooa bo nang le thibelo ea bobeli ea lits'ebetso tsa "Idebenone" ho bakuli ba nang le mathomo a mabeli a eplerosis (IPPoMS).