FDA-Approved Hepatitis C Lithethefatsi

Meriana e fanang ka meriana ea pheko e ka hodimo ho karolo ea 99 lekholong

Ha moriana oa Sovaldi (sofosbuvir) o ne o qala ho tsejoa ka September 2014, ha oa ka oa tšoaea feela phetoho ea leoatleng hore na tšoaetso ea lefu la hepatitis C e tšoaroa joang, e ile ea etsa hore meriana ea moloko pele ho moo e se ke ea e-ba teng. Ka mor'a hore Sovaldi a fihle likhoeli tse seng kae, lefu la hepatitis C le ts'oanang le Incivek (telaprevir) le Victrelis (boceprevir) ba ile ba tsoa ka 'marakeng ka potlako, ba se ke ba hlola ba bonoa hape.

Ho latela ka tieo lirethe tsa Sovaldi ke ho kenyelletsa lihlahisoa tse ling tse tšeletseng tsa lithethefatsi tse khonang ho phekola mefuta e mengata ea liphatsa tsa lefutso tsa lefu la sebete la Hepatitis C. Lithethefatsi tsena tse ncha ha lia ka tsa fana ka litla-morao tse fokolang, li ile tsa fokotsa mokhoa oa phekolo ka likhoeli tse tharo.

Le lihlahisoa tsa phekolo tse fetang karolo ea 95 lekholong maemong a mangata, phephetso ea sebele feela ke mokhoa oa ho atolosa phihlelo ho batho ba 130 ho ea ho tse 150 ba tšoaelitsoeng ke lefu la hepatitis C lefatšeng ka bophara.

Mona ke lits'ebeletso tse robeli tse ncha tsa phekolo ea lefu la hepatitis C, tse thathamisitsoeng ke taelo ea tumello ea bona ea FDA:

1 -

Epclusa

E amoheletsoeng ka la 28 June, 2016, Epclusa (sofosbuvir, velpatasvir) ke lisebelisoa tse peli ka bonngoe tse kopanetsoeng tse khonang ho tšoara liphatsa tsa lefutso tse kholo tse tšeletseng tsa lefu la sebete. E ka sebelisoa ho tšoara batho ba nang le boloetse ba ho ruruha (ho kopanyelletsa le ho ruruha ha cirrhosis ). Epclusa e behiloe ka tekanyo ea hang-hang ea letsatsi ka nako ea libeke tse tšeletseng ho isa ho tse tšeletseng.

Hape

2 -

Mofokolisi

E amoheletsoe ka Senyesemane 2016, Zepatier (elbasvir, grazoprevir) ke motsoako o tsitsitseng oa lithethefatsi o sebelisetsoang ho phekola genotype 1 le 4 e nang le kapa ntle le boloetse ba sebete. Zepatier ke phekolo ea pilisi e le 'ngoe e sa hlokeng hore e tsamaisoe ka lithethefatsi leha e le life. E nkoa hang ka letsatsi ka libeke tse 12 ho ea ho tse 16, kapa ho se na lijo, ho itšetlehile ka mofuta oa genotype motho a nang le oona le hore na motho o kile a tšoaroa ka lefu la lefu la sebete kapa che.

Hape

3 -

Daklinza

E amoheletsoe ka July 2015, Daklinza (daclatasvir) e sebelisoa kalafo e kopanetsoeng ho phekola lefu la lefu la sebete la mofuta oa 3. Daklinza e ne e le setsi sa pele se sebetsang ka ho toba se khonang ho tšoara genotype 3 ntle le ho kenyelletsa peginterferon kapa ribavirin . Daklinza e nkiloe le Sovaldi hanngoe ka letsatsi le letsatsi le e-na le lijo kapa li se na lijo ka libeke tse 12.

Hape

4 -

Technivie

E amoheletsoe ka July 2015, Technivie (ombitasvir, paritaprevir / ritonavir) ke lithethefatsi tse sebelisoang kalafo e kopanetsoeng ho tšoara batho ba nang le tšoaetso ea genotype 4. Lisebelisoa tse tharo tsa lithethefatsi tse kenyelletsang Technivie li kenyelletsoa likhethong tse peli tsa pilisi, Viekira Pak . Tekanyo e khothalletsoang ke matlapa a mabeli a nkiloeng habeli ka letsatsi le ribavirin libeke tse 12.

Hape

5 -

Viekira Pak

E amoheletsoe ka December 2014, Viekira Pak ke phekolo ea meriana e kopantsoeng e sebelisetsoang ho phekola lefu la sebete la hepatitis C le nang le tšoaetso kapa le se nang tšoaetso. Paka e kenyelletsa khoebo ea Technivie e kopantsoe hammoho le lithethefatsi tse ling tse tsejoang e le dasabuvir. Tekanyo e khothalletsoang ke matlapa a mabeli a Technvie a nkiloeng hanngoe ka letsatsi le lijo le letlapa le le leng la dasabuvir e nkiloeng habeli ka letsatsi le lijo. Nako ea phekolo e tsoa libeke tse 12 ho isa ho tse 24.

Hape

6 -

Harvoni

E amoheletsoe ka October 2014, Harvoni (ledipasvir, sofosbuvir) ke motsoako o tsitsitseng oa tekanyo e sebelisetsoang ho phekola mafu a li-genotype a 1 le a 4 a nang le tšoaetso kapa e se nang tšoaetso. E ka boela ea sebelisoa maemong a mang a genotype 3. Harvone e ne e le eona ea pele ea ho sebelisa lithethefatsi ka ho feletseng e sa kang ea hloka kho-administration le peginterferon kapa ribavirin. Tekanyo e khothalletsoang ke tefo e le 'ngoe letsatsi le leng le le leng e nkiloeng ka ntle le ntle le lijo Nako ea phekolo e tsoa libeke tse 12 ho isa ho tse 24.

Hape

7 -

Sovaldi

E amoheletsoe ka December 2013, Sovaldi (sofosbuvir) ke buka e tobileng-e sebelisang lithethefatsi tse thibelang likokoana-hloko tse sebelisetsoang ho phekola li-genotypes 1, 2, 3 le 4. Tekanyo e khothalletsoang ke letlapa le le leng letsatsi le leng le le leng le nkiloeng ka ntle le ntle le lijo. Ho itšetlehile ka genotype, ribavirin e ka kenngoa phekolo. Bakeng sa tšoaetso ea genotypes 3, Sovaldi e tsamaisana le Daklinza. Nako ea phekolo e tsoa libeke tse 12 ho isa ho tse 24.

Hape

8 -

Olysio

E amoheletsoe ka November 2013, Olysio (simeprevir) ke protease inhibitor-class drug e sebelisetsoang ho phekola kalafo ho phekola batho ba nang le lefuba la lefu la hepatitis C. Li-Olysio li sebelisoa hammoho le li-peginterferon le ribavirin ka nako ea libeke tse 24 ho isa ho tse 36. Tekanyo e khothalletsoang ke tablet e le 'ngoe e nkiloeng letsatsi ka leng le lijo.

Hape