Li-monocyte li Sebetsa Ts'ebetso ea 'Mele ea' mele
Li-monocyte ke mofuta oa sele e tšoeu ea mali. Joaloka lisele tse ling tse tšoeu tsa mali, li-monocyte ke tsa bohlokoa matla a 'mele ea ho itšireletsa mafung, empa hape le ho thusa ho folisa le ho lokisa. Li-monocyte li thehoa lerung la masapo 'me li lokolloa mali a meleng, moo li tsamaeang ka matsatsi a' maloa. Li na le hoo e batlang e le karolo ea 5-10 lekholong ea lisele tse tšoeu tsa mali tse potolohileng batho ba phelang hantle.
Li-monocyte li tsebahala haholo ka karolo ea tsona ea ho sebetsa e le ntho e lekaneng ho boloka mabotho a sesole. Tse ling tsa tsona li ka 'na tsa bitsoa haeba ho hlokahala, ho etsa li-precurse tsa mefuta e meng e' meli ea lisele tse tšoeu tsa mali: macrophages le lisele tsa dendritic . Empa li-monocyte li boetse li na le karolo e meng ea tšoaetsano le maloetse, ao a mang a 'ona a sa amane le macrophages le lisele tsa dendritic.
Li-monocyte tse phetseng hantle li etsa'ng 'meleng?
Ho fihlela morao tjena, karolo e ka sehloohong ea li-monocyte e ne e nkoa e le ho lemoha tikoloho ebe e tlatsa letamo la macrophages le lisele tsa dendritic, ha ho hlokahala.
Hona joale hoa tsebahala hore li-subsette tse fapaneng tsa monocyte li na le li-marker tse fapaneng, kapa li-protheme tse ka ntle, mme li-subset tsena li ka boela tsa itšoara ka tsela e fapaneng. Mefuta e meraro e sa tšoaneng ea monocyte ea batho e hlalosoa hona joale:
- Li-monocyte tsa boholo-holo li na le hoo e ka bang karolo ea 80 lekholong ea palo ea batho bohle ba monocyte.
- Tse ling tse 20 tse setseng li ka aroloa ka maqiti a tsona a protheine
- li-monocyte tse sa tloaelehang le
- monocyte e bohareng.
Ha ho tluoa tabeng ea mefuta e fapaneng ea monocyte le hore na e sebetsa joang tsamaisong ea 'mele ea ho itšireletsa mafung, bafuputsi ba sa ntse ba etsa lintlha tse ngata,' me tse ling tse ngata hona joale li tsejoa ka monocyte ea mouse ho feta monocyte ea motho.
Mantsoe "ho ruruha" le "anti-inflammatory" a boetse a sebelisetsoa ho hlalosa monocyte ea motho, e thehiloeng ho li-tags tse itseng tsa protheine, kapa li-receiving, tse fumanoang ka ntle ho lisele tsena. Ha e e-s'o tiisehe ho batho, leha ho le joalo, ke karolo efe ea li-monocyte tse tsamaeang ka mokhoa o lekaneng ho kena le ho tsoa ka mahlahahlaha, 'me bopaki bo fana ka maikutlo a hore ho na le mefuta ea monocyte e ka khonang le ho cheka, kapa phagocytize, bahlaseli empa e sa khothalletse ho ruruha.
Ka Spleen
Ho nahanoa hore li-monocyte tse ngata li fallela ka har'a 'mele oa hao moo li ka lulang teng kapa li hlahisa macrophages e etsang mesebetsi ea bohlokoa ho loantša tšoaetso le ho hloekisa lisele tse shoeleng. Spleen e na le mefuta eohle e meholo ea "mononuclear phagocytes," ho akarelletsa le macrophages, lisele tsa dendritic le monocyte. Ka tsela ena, spleen e ka ba sebaka se sebetsang sa tsamaiso ea 'mele ea ho itšireletsa mafung .
Innate Immunity
Ho itšireletsa mafung ho sa hlokahale ho bolela ho itšireletsa mafung ao u tsoetsoeng le 'ona, eseng ho itšireletsa mafung a mangata ho ka' na ha hlaha ka morao, ho re, ente kapa ka mor'a ho hlaphoheloa ke boloetse bo tšoaetsanoang. Mokhoa oa ho itšireletsa mafung oa innate o sebetsa ka mekhoa e sa tšoaneng, ho akarelletsa phagocytosis le ho ruruha. Macrophages e ka kenela phagocytosis, e leng mokhoa oo li kenang ka oona le ho senya marotholi le lihlaseli.
Ba ka boela ba "tlohela mosebetsi" leha e le ofe oa khale, ba lemose lisele tse khubelu tsa mali ka tsela ena. Macrophages ka spleen e thusa ka ho hloekisa mali a litšila le lisele tsa khale, empa le tsona li ka thusa li-lymphocyte hore li lemohe bahlaseli ba tsoang linaheng tse ling. Ha sena se etsahala, se bitsoa mehlala ea antigen. Karolo ena ea ho qetela, tlhahiso ea antigen, ke moo tsamaiso ea 'mele ea ho itšireletsa mafung e qetelloang teng le moo ho fumanoeng kapa ho ithuta ho itšireletsa mafung ho motho ea hlaselang ka ntle ho naha ho qala.
Li-Monocyte li Thusa ho loantša tšoaetso ka litsela tse sa tšoaneng
Ho tloha ka holimo, rea tseba hore li-monocyte tse ling li fetoha macrophages likarolong tse kang Pac-Man, ho qhaqha libaktheria, likokoana-hloko, litšila le lisele leha e le life tse tšoaelitsoeng kapa tse kulang.
Ha li bapisoa le li-infantry tse khethehileng tsa immune, li-T-cell, macrophages li fumaneha kapele ho lemoha le ho hlasela tšoso e ncha. Ba ka ba ba lutse maemong a bona a tloaelehileng a li ratang, kapa ba ka fallela kapele sebakeng sa ho ruruha moo ba ka hlokang ho loantša tšoaetso.
Li-monocyte tse ling li fetoloa hore e be lisele tsa dendritic lihloeng, moo li sebetsang le li-lymphocyte tsa T. Macrophages e ka boela ea hlahisa li-antigen tsa T-lisele, empa lisele tsa dendritic li 'nile tsa nkoa e le litsebi tse ngata tabeng ea mosebetsi ona.
Ba bokella lithōle ho senyeha ha libaktheria, livaerase le lisebelisoa tse ling tse tsoang linaheng tse ling ebe ba li beha ho li-T-cell e le hore li ka li bona 'me li iketsetse karabo ea' meleng ho bahlaseli. Joaloka macrophage, lisele tsa dendritic li khona ho hlahisa likokoana-hloko ho li-T-cell moemong o itseng, joalokaha eka ho re, "Heba sheba sena, na u nahana hore re lokela ho etsa ho eketsehileng ka see?"
Li-monocyte Lipelong Tsa Batho
Ha u e-na le teko ea mali ea CBC e etsoang ka phapang, li-monocyte tse tšoeu tsa mali li baloa 'me palo e tlalehoa, hammoho le hore na ke karolo efe ea lisele tse tšoeu tsa mali tse tšoeu tsa monocyte.
- Ho eketseha ha monocyte ho ka bakoa ke tšoaetso ea baktheria, li-fungus kapa vaerase. E ka boetse ea e-ba karabo ho khatello ea kelello. Maemong a mang, litekanyetso tse phahameng tsa monocyte li ka bakoa ke bothata ka tsela eo 'mele oa hao o etsang lisele tse ncha tsa mali,' me maemong a mang, ho feteletseng ho bakoa ke ho bolaea, joalo ka mefuta e itseng ea kankere ea mali.
- Maemong a tlaase a monocyte a ka bonoa ka mor'a chemotherapy , hangata hobane kakaretso ea lisele tsa mali tsa hao e tlaase.
Ho batho, li-monocyte li 'nile tsa ameha ka maloetse a' maloa ho akarelletsa le tšoaetso ea likokoana-hloko, tšabo e mpe le e potlakileng ea likarolo, ho kula ha masapo, lefu la pelo, mafu a metsoako le maloetse a mangata. Leha ho le joalo, ho ka etsahala joang hore mefuta e fapaneng ea monocyte e itšoare ka maloetse a sa tšoaneng a batho e ntse e le sebaka sa lipatlisiso tse sebetsang.
Monocytes ho Listeria
Listeria monocytogenes ke mofuta oa libaktheria tse ka bakang listeriosis, boloetse bo tummeng ba ho ja lijo. Litlhokomelo tsa Listeria ke tse ling tsa tse fanoeng nakong ea bokhachane, kaha listeria e ka baka meningitis ho masea a sa tsoa tsoaloa; hangata bo-'mè ba moimana ba eletsoa hore ba se ke ba ja li-cheeses tse bonolo, tse ka 'nang tsa e-ba le listeria.
Hoa etsahala hore li-monocyte li ka thusa ho loantša tšoaetso, empa hape e ka ba "lipere tsa Trojan," ka ho tsamaisa libaktheria boko, 'me seo se amehile ka listeria. Listeria e kena ka har'a li-monocyte, empa joale li-monocyte ha li khone ho bolaea libaktheria 'me lia ata.
Monocytes ka Leukemia
Moeli oa lisele tse hlahisang monocyte li ka senyeha 'me tsa ata ka taolo. Lefuemia e matla haholo ea monocytic, kapa "FAB subtype M5" e sebelisang tsamaiso e le 'ngoe ea lihlopha, ke e' ngoe ea mefuta ea mafu a myelogenous leukemia . Ka M5, karolo ea 80 lekholong ea lisele tse senyehileng ke monocyte.
Ha motho a sa phekolehe lefu la myelomonocytic leukemia, kapa CMML, ho na le palo e eketsehileng ea monocyte le lisele tsa mali tse se nang mali maling a bone le ho potoloha maling. CMML e na le litšobotsi tse peli tse fapaneng tsa mali, kahoo e arotsoe ka mokhoa oa ho sebelisa tsamaiso ea lihlopha tsa lefapha la lefats'e la bophelo bo botle: myelodysplastic syndrome / myeloproliferative neoplasm , kapa MDS / MPN. E ka tsoela pele ho ea ho mafu a myeloid a leukemia hoo e ka bang karolo ea 15-30 lekholong ea bakuli.
Li-monocyte tse Lymphoma le li-Cancers tse ling
Bafuputsi ba fumana hore li-monocyte li ka ba le liketso tse sa rateheng mabapi le li-tumor le boitšoaro ba kankere ea lelapa la tšoeu ea lisele tsa mali (mafu ana a tsejoa e le mafu a lymphoproliferative).
Ho ba teng ha macrophages le mesebetsi ea bona ka lihlahala li 'nile tsa amahanngoa le ho nolofalletsa lisele tsa' mele hore li hahe mali le ho hlasela le ho feta ka mali. Nakong e tlang, ho fumanoa hona ho ka lebisa tlhokomelo ea phekolo e thibelang macrophage ho thibela metastasis le kholo ea hlahala.
Bakeng sa maloetse a fapa-fapaneng, lingaka tse ling li qala ho sebelisa palo e feletseng ea monocyte e le pontšo ea kotsi, kapa ho hlaseloa ho hobe pele ho kalafo. Palo e eketsehileng ea monocyte e ka holimo ho monyako o itseng e amana le liphello tse futsanehileng ho bakuli ba nang le T-cell lymphomas le lefu la Hodgkin . Tlhaloso ea lymphocyte-to-monocyte e ka boela ea thusa ho tseba bakuli ba kotsing e kholo ea B-cell lymphoma e kholo le kankere e sa sebetseng ea methapo ea kankere.
Lisebelisoa:
Tadmor T (2013) Li-monocyte, Myeloid ea Monocytic e Nkiloeng ke Li-cell phone le Lymphoma: Ke joang Tight is Knot of the Tie? J Leuk (Los Angel) 1: e103.
Eigenbrod T, Dalpke AH. J Immunol. Bacterial RNA: Tšusumetso e sa Lebelloang bakeng sa Likarabo tsa 'mele tsa ho itšireletsa mafung. 2015; 195 (2): 411-8.
Gui-Nan Lin, le. al. " Boikarabello ba selelekela sa karolelano ea pele-chemotherapy ea lymphocyte-to-monocyte ho bakuli ba nang le kankere e chesang ea metastatic pele e sa sebetsoe ba fumanang chemotherapy ea FOLFOX ." Chin J Kankere . 2016 Dec; 35: 5.