Li-Fibrate, tse tsejoang hape e le li-derivatives tsa fiber, ke sehlopha sa lipilisi tse fokolang lipilisi tse nang le bokhoni ba ho ama likarolo tsohle tsa boemo ba hau ba molomo.
Tsela eo fibrate e ka tlase e nang le k'holeseterole e theoha ka eona. Li-fibrate li kenyelletsa protheine e bitsoang peroxisome proliferator-activated receptor alpha (PPAR-alpha). Protheine ena e ka hlahisa enzyme e 'ngoe, lipoprotein lipase, e fokotsang palo ea apolipoprotein C-III ' meleng.
Qetellong, sena se fella ka ho fokotsa sebopeho sa VLDL le triglycerides le ho eketsa ho senyeha ha lipids. Li-Fibrate li boetse li eketseha ka maemo a HDL ka ho eketsa lenane la apolipoprotein AI le A-II e entsoeng 'meleng.
Hona joale ho na le lithethefatsi tse peli tsa fibrate tse amoheletsoeng hore li sebelisoe ke Tsamaiso ea Lijo le Drug (FDA) United States:
- Gemfibrozil (Lopid)
- Fenofibrate (Tricor)
Li-fibrate li tsebahala ka ho fokotsa triglycerides le ho eketsa k'holeseterole ea HDL. Leha ho le joalo, li ka ama likarolo tsohle tsa boemo ba hau ba molomo. Ka kakaretso, fibrates e ka:
- Fokotsa li-cholesterol tsa LDL ka karolo ea 5 ho ea ho karolo ea 20 lekholong.
- Eketsa k'holeseterole ea HDL ka kae kapa kae pakeng tsa 10 lekholong le 35 lekholong.
- Fokotsa maemo a hau a triglyceride ka karolo ea 20 ho ea ho karolo ea 50 lekholong.
E le ho ntlafatsa katleho ea lipilisi tsa hau, fibrates e ka nkoa e le mong kapa e kopane le li-agent tse fokolang lipilisi, tse kang statins kapa omega-3 fatty acids.
Kamoo U Lokelang ho Nka Nakofatsi
U lokela ho nka fibrate ea hao hantle feela joalokaha e laetsoe ke mofani oa hao ea tlhokomelo ea bophelo 'me u lokela ho netefatsa hore u se ke ua hloloheloa litekanyetso leha e le life. Meriana eohle ea fibrate e fumaneha ka foromo 'me e nkoa ka molomo. Le hoja u ka nka mefuta e 'meli ea fibrate kapa ntle le lijo; leha ho le joalo, liphuputso li bontšitse hore ho nka fibrate, gemfibrozil, ka lijo ho thusa ho eketsa ho nkoa ha eona.
Hape o lokela ho etsa bonnete ba hore u se ke ua hloloheloa likopano tsa hau le mofani oa hao oa tlhokomelo ea bophelo, hobane o tla hloka ho hlahloba hore na meriana eu sebeletsa kapa che. Mofani oa hao oa tlhokomelo ea bophelo o ka 'na a hloka ho etsa liphetoho kalafo ea ho fokotsa lipilisi, ho itšetlehile ka hore na u arabela joang le lithethefatsi. Ha u ntse u nka fibrate - kapa mofuta leha e le ofe o fokolang lipilisi - u lokela ho latela haufi le lijo ho fokotsa k'holeseterole le triglycerides.
Na ho na le Liphello Tseo U ka li Batlang?
Le hoja li-fibrate li mamelloa hantle har'a batho ba li nkang, u ka ba le litla-morao tse ling ka ho li nka, Litla-morao tse tloaelehileng tse kenyelletsoeng li kenyelletsoa ho kenyeletsa mathata a bakoang ke meno, joalo ka ho nyekeloa ke pelo, letšollo le bohloko ba mpeng. Hangata litla-morao tsena li bonolo ebile, maemong a mangata, li qeta ka mor'a ho qala fibrate ea hau.
Maemong a mang, fibrate e ka eketsa li-enzyme tsa sebete, kahoo ho phaella ho lipids tsa hao, mofani oa hao oa tlhokomelo ea bophelo o tla boela a hlahlobe li-enzyme tsa sebete nako le nako. Haeba u e-na le boloetse ba kokoana-hloko, u lokela ho lumella mofani oa hao oa tlhokomelo ea bophelo hore a tsebe, kaha ho na le kotsing e nyenyane ea ho ba le li-gallstones ha u ntse u nka fiber. Lihlabula li ka boela tsa baka boemo bo boleloang e le rhabdomyolysis.
Le hoja e le ntho e sa tloaelehang, kotsi ea ho ba le boemo bona ha u ntse u nka fibrate e eketsa haeba u noa meriana e itseng hammoho le fibrate ea hao kapa u na le maemo a mang a bophelo.
Li-fibrate li ka eketsa menyetla ea ho ba le mali ha u nka mali a fokolang, a kang Coumadin ( warfarin ). Ka lebaka la sena, mofani oa hao oa tlhokomelo ea bophelo o ka fetola lethal dose ha a ntse a nka fibrates.
Litla-morao tse bakoang ke fibrate hangata li bobebe, empa li lokela ho lebisoa tlhokomelong ea mofani oa tlhokomelo ea tlhokomelo ea bophelo ha li e-ba khathatso kapa li phehella nako e itseng. U lokela ho lumella mofani oa hao oa tlhokomelo ea bophelo hore a tsebe meriana leha e le efe eo ue nkang - ho akarelletsa le lihlahisoa tsa litlama kapa tse ling-kapa tsa bongaka tseo u nang le tsona e le hore a ka u lekola haufi-ufi nakong ea phekolo.
Lisebelisoa:
> Dipiro JT, Talbert RL. Pharmacotherapy: Pathophysiological Approach, 9th, 2014.
Malloy MJ, Kane JP. Mahlaseli a sebelisitsoeng ho Dyslipidemia. Ka: Katzung BG, Trevor AJ.eds. Basic & Clinical Pharmacology, 13e . New York, NY: Hill ea McGraw; 2015.