Livalo (pitavastatin) ke meriana e theohelang k'holeseterole ea sehlopha sa statin ea lithethefatsi. E sebelisetsoa ho phahamisa lipilisi tse phahameng mongoaneng o moholo oa hyperlipidemia kapa meriana e tsoakiloeng ea dyslipidemia maemong ao ho ja lijo, phetoho ea bophelo, kapa meriana e meng ha e fokolise litekanyetso tsa lipid. Livalo ke e 'ngoe ea li-statins tse matla haholo marakeng.
Ho ea ka liphuputso, baetsi ba Livalo, 2 mg ea Livalo e sebetsa hantle ho theola lipids ka 10 mg ea Lipitor (atorvastatin).
Ho phaella moo, 2 mg ea Livalo e theola k'holeseterole ho isa tekanyo e lekanang le 20 mg ea Zocor (simvastatin). Joaloka li-statine tse ling, Livalo e ama likarolo tsohle tsa boemo ba hau ba k'holeseterole: E theola LDL le triglycerides le ho phahamisa HDL . Liphuputso tse ikhethang tse hlahlobang phello ea Livalo lihlopheng tsa lipilisi li bontšitse hore:
- Cholesterol ea LDL e theoleloa ke hoo e ka bang 44%
- Kakaretso ea k'holeseterole e theoha ka 32%.
- Triglycerides e theoleloa ke 19%.
- Li-cholesterol tsa HDL li eketseha ka karolelano ea 5%.
- Apolipoprotein B e theoleloa ke hoo e ka bang 35%.
Livalo e ile ea amoheloa hore e sebelisoe United States ke Tsamaiso ea Lijo le Drug (FDA) ka August 2009. Pele ho amoheloa US, pitavastatin e ne e fumaneha bakeng sa ho sebelisoa linaheng tse ling ho feta lilemo tse hlano pejana.
Livalo e Sebetsa Joang?
Livalo e thibela enzyme e bitsoang 3-hydroxy-3methylglutaryl coenzyme A (HMG CoA) reductase, e leng protheine ea bohlokoa e hlokahalang ho hlahisa k'holeseterole 'meleng.
Ketso ena e fokotsa k'holeseterole eohle, LDL le cholesterol ea VLDL 'meleng.
Livalo e Lokela ho Nkoa Joang?
Livalo e fumaneha ka foromo 'me e ka nkoa ka ntle kapa ka ntle hang ka letsatsi, joalokaha e laoloa ke mofani oa tlhokomelo ea bophelo. Li-Livalo ha lia lokela ho feta 4 mg ka letsatsi. Livalo e lokela ho nkoa hammoho le lijo tse fokolang ho theola k'holeseterole le triglycerides.
Hangata livalo e ngotsoe ha bophelo bo fetoha kapa meriana e meng ha e fokotse lipids tsa hao ka katleho.
U lokela ho etsa bonnete ba hore u ea libokeng tsa hao tsa tlhokomelo ea tlhokomelo ea bophelo ka nako e le 'ngoe ho tloha moo a tla hloka ho hlahloba litekanyetso tsa lipid, hammoho le lisebelisoa tse ling, ha u ntse u noa meriana ena.
Ke Mang ea sa Lokelang ho Nka Livalo?
Haeba u na le e 'ngoe ea maemo a bongaka a thathamisitsoeng ka tlase, ha ua lokela ho nka Livalo. MAHLENG ana, mofani oa hao oa tlhokomelo ea bophelo a ka u beha kalafo e fapaneng ho fokotsa lipids tsa hau:
- Fetela ho Livalo . Haeba u se u kile ua finyella Livalo kapa lintho tsohle tsa eona, ha ua lokela ho noa meriana ena.
- Matšoao a sebete a sebetsang . Haeba o na le boloetse bo sebetsang ba sebete kapa maemong a sa tloaelehang a enzyme ea sebete, Livalo ha ea lokela ho nkoa.
- Boimana. Livalo e na le likarolo tse kang mokhachane oa sehlopha sa X. Livalo e 'nile ea bontšoa hore e tšela sebaka se ka tlaase ho likhoto' me ho bile le litlaleho tsa ho senyeha ha maikutlo le ho se fetele ha liphoofolo liphoofolong. Ho phaella moo, sena se boetse se tlalehiloe ho basali ba imme ba noang meriana ea molao. Haeba u rerile ho ima kapa u se u ntse u imme 'me u nka Livalo, mofani oa hao oa tlhokomelo ea bophelo o tla lekanyetsa melemo ea ho noa meriana bophelong ba hao le mathata a ka bang teng ho ngoana oa hau.
- Booki. Livalo e 'nile ea bontšoa hore e tšela lebese. Ha ho tsejoe hore na sena se ka ba le phello efe ho ngoana oa hau.
- Ho sisinya Cyclosporine. Meriana ena e ka eketsa mabala a Livalo 'meleng, e ka' nang ea baka liphello tse kotsi 'meleng. Moetsi o khothalletsa hore haeba u nka Livalo, ha ua lokela ho nka cyclosporine.
Ke maemo afe ao ho hlokahalang hore a behoe hloko ha a ntse a nka libuka?
Haeba u nka Livalo, mofani oa hao oa tlhokomelo ea bophelo o ka 'na a hloka ho u hlahloba haufi haholo haeba u e-na le maemo a itseng a bophelo a ka fetisetsoang ka ho noa meriana. Haeba u na le maemo a latelang a latelang, mofani oa hao ea tlhokomelo ea bophelo a ka 'na a etsa qeto ea ho qala ka Livalo ka tekanyo e tlaase,' me o tla hloka ho u lebela hore a tsebe hore na li tla nka eng kapa li se ke tsa u ntša kotsi.
Maemo ana a bongaka a kenyelletsa:
- Li-enzyme tse phahameng tsa sebete. Libukeng, Livalo e ile ea eketsa sebete sa sebete sa aspartate aminotransferase (AST) le alanine aminotransferase (ALT). Le hoja hangata keketseho ena ke ea nakoana, mofani oa hao oa tlhokomelo ea bophelo o tla hlokomela litekanyetso tsena ho netefatsa hore li-enzyme tsa sebete ha li phahamisetsoe litsing tse kotsi.
- Maloetse a liphio. Haeba u e-na le lefu la liphio tse itekanetseng kapa tse matla, mofani oa hao oa tlhokomelo ea bophelo a ka 'na a qala ka tekanyo e tlaase ka ho fetisisa ea Livalo' me a shebella bophelo bo botle ha u le meriana.
- Litekanyo tse phahameng tsa tsoekere ea mali. Liphuputso li bontšitse hore Livalo e ka eketsa hemoglobin A1C le ho itima lijo ka lebelo la tsoekere. Haeba o na le lefu la tsoekere, mofani oa hao oa tlhokomelo ea bophelo a ka 'na a shebella likarolo tsena tsa mali' me a fetola lethal dose ea Livalo.
Ke Mefuta Efe ea Litla-morao e Tla Etsahala?
Litla-morao tse tloaelehileng ka ho fetisisa li kenyeletsa bohloko ba morao, mathata a bokhachane (ho kang ho patoa kapa letšollo), mahlaba a mesifa le bohloko maemong. Tse ling tsa litla-morao tse tloaelehileng tse nang le phihlelo li kenyelletsa hlooho le bohloko bo kopantsoeng Haeba u e-na le litla-morao tse ling ha u nka Livalo e leng nako e telele kapa e khathatsang, u lokela ho lumella mofani oa hao oa tlhokomelo ea bophelo hore a tsebe.
Joaloka li-statins tse ling, liphello tse sa tloaelehang - rhabdomyolysis - li ka boela tsa etsahala ho batho ba nkang Livalo. Matšoao a rhabdomyolysis a kenyeletsa mesifa le ho fokola, hammoho le motsoako o nang le soda. Kotsi ea hau ea litla-morao tsena e ka etsahala haeba o noa meriana e meng, lilemo tse eketsehileng le maemo a mang a bophelo. Haeba u e-na le matšoao afe a rhabdomyolysis, o lokela ho tsebisa hang-hang mofani oa hao oa tlhokomelo ea bophelo.
Na ho na le Meriana leha e le efe e ka sebelisanang le Livalo?
Lithethefatsi tse latelang li ka sebelisana le Livalo, ho eketsa monyetla oa ho ba le litla-morao (haholo-holo myopathy). Ntle ho k'holeseterole-ho theola lithethefatsi tse thathamisitsoeng ka tlaase, lithethefatsi tsena li ka eketsa boholo ba Livalo 'meleng oa hau.
- Lithethefatsi tse fokolang tsa k'holeseterole ( nicotinic acid , fibrates)
- Rifampin
- Erythromycin
- Colchicine
Lena hase lenane le feletseng. U lokela ho lumella mofani oa hao oa tlhokomelo ea bophelo hore a tsebe meriana eohle - ho kopanyelletsa le meriana ea litlama le lithethefatsi tse ngata-tseo u li nkang ha u ntse u nka Livalo. Sena se tla u thusa mohlokomeli oa tlhokomelo ea bophelo ho u shebella ka ho khoneha ho sebelisana ha lithethefatsi ha u noa meriana. Haeba ho hlokahala hore u nke lithethefatsi tse thathamisitsoeng ka holimo, mofani oa hao oa tlhokomelo ea bophelo o ka 'na a hloka ho fetola lethal dose, ho lekola haufi le litla-morao, kapa ho khaotsa lithethefatsi tse ling.
The Bottom Line
Livalo ke meriana ea morao-rao e fokolang lipilisi tse amohelehang ho rōna United States. Liphuputsong tse ling, ho bonahala eka e sebetsa hantle ho fokotsa lipids ka litekanyo tse lekaneng tsa simvastatin le atorvastatin. Livalo e bonahala e feta tseleng e 'ngoe sebeteng e le hore e be le metaboli e bapisoang le li-statine tse ling, e fokotsang palo ea likamano tsa lithethefatsi tse boleloang ke batho ba noang meriana ena. Leha ho le joalo, Livalo ha e e-s'o ithute haholo ho thibela lefu kapa bokooa ka lebaka la lefu la pelo.
Lisebelisoa
Duggan ST. Pitavastatin: tlhahlobo ea tšebeliso ea eona tsamaisong ea hypercholesterolemia kapa meriana e tsoakiloeng ea dyslipidemia. Lithethefatsi 2012; 72: 565-584.
Ose L, Budinski D, Hounslow N, et al. Ho bapisa pitavastatin le simvastatin mantlha ea hypercholesterolaemia kapa ho kopantsoe ha dyslipidaemia. Curr Med Res & Opin 2009; 25: 2755-64 15.
Budinski D, Arneson V, Hounslow N, le al. Pitavastatin ha e bapisoa le atorvastatin e ka sehloohong ea hypercholesterolemia kapa e kopantsoeng le dyslipidemia. Clin Lipidol 2009; 4: 291-302
LIVALO [sephutheloana sa liphutheloana]. Cincinnati, OH: Koa Pharmaceuticals America, 10/2013
Micromedex 2.0. Truven Health Analytics, Inc. Greenwood Village, CO. E fumaneha ho: http://www.micromedexsolutions.com. E fihlile ka la 10 February , 2016