Karate ea kharenate eo hangata e neng e nkoa e le ea tloaelehileng, hona joale e tumme haholo. Jere ea kharenate e fumanoa hoo e batlang e le lebenkele le leng le le leng la Amerika Leboea.
Empa tlaleho ea nyeoe e hlahang tokollong ea September 1, 2006 ea American Journal of Cardiology e fana ka maikutlo a hore likharenate li ka sebelisana le meriana e tloaelehileng.
Monna e mong ea lilemo li 48 o ne a nka ezetimibe (Zetia®) 10 mg ka letsatsi le rosuvastatin (Crestor®) 5 mg ka letsatsi le leng ka likhoeli tse 17.
Ka bobeli meriana e sebelisoa bakeng sa k'holeseterole e phahameng.
O ile a qala ho noa lero la kharenate (200 ml ka makhetlo a mabeli beke le beke) le libeke tse tharo hamorao, a amoheloa ka tšohanyetso ka bohloko ba leqeba le tekanyo e phahameng ea serum creatine kinase (138,030 U / L, e tloaelehileng <200 U / L). Ka bobeli ke matšoao a rhabdomyolysis, boemo bo tebileng bo bakang ho senyeha ha mesifa ea 'mele le ho ka lebisa ho liphio ho hlōleha.
Rosuvastatin ke ea sehlopha sa meriana e bitsoang HMG-CoA reductase inhibitors, kapa 'statins'. Merosa ea litholoana tsa morara o tsejoa ho eketsa kotsi ea ho ba le myopathy e bakoang ke statin, empa ho fihlela joale, ho ne ho e-na le tlhahisoleseding e nyenyane mabapi le hore na lero la kharenate le tsona le ka eketsa kotsi.
Jarate ea kharenate le lero la morara, li tsejoa ka bobeli ho thibela tsamaiso ea cytochrome P450 3A4 ea lik'hemik'hale ka maleng. Ka ho thibela li-enzyme tsena, lero le ka eketsa meriana e mengata ea mali.
Ho ka 'na ha e-ba le Likamano le Meriana ea Lithethefatsi
- Antiarrhythmics - Amiodarone (Cordarone®), disopyramide (Norpace®), quinidine
- Li-calcium channel blockers - Felodipine (Plendil®), nicardipine (Cardene®), nifedipine (Procardia®), nimodipine (Nimotop®), nisoldipine (Sular®)
- Statins - Atorvastatin (Lipitor®), lovastatin (Mevacor®), simvastatin (Zocor®)
- Immunosuppressants - Cyclosporine (Sandimmune®, Neoral®), tacrolimus (Prograf®)
- Protease inhibitors - Saquinavir (Fortovase®)
Leha ho le joalo, lero la kharenate le lona le ka sebelisana le meriana e seng lethathamong lena.
Ezetimibe ea lithethefatsi le rosuvastatin ha li nahane hore li robehile ke cytochrome P450 3A4.
Ho itšetlehile ka bopaki bo fokolang mabapi le ho sebelisana ha lithethefatsi, ke habohlokoa hore u buisane le ngaka ea hau haeba u noa meriana 'me u nahana ho noa lero la kharenate.
Lisebelisoa:
Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K. Liphello tsa lero la kharenate holim'a cytochrome ea motho p450 3A (CYP3A) le carbamazepine pharmacokinetics ka likhoto. Tšebeliso ea Metabolism le Litlhahiso. 33.5 (2005): 644-8.
Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. Litla-morao tsa li-juice tsa litholoana mosebetsing oa CYP3A. Tšebeliso ea Metabolism le Litlhahiso. 34.4 (2006): 521-3.
Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis e amahanngoa le tšebeliso ea lero la kharenate. Journal of American Cardiology. 98.5 (2006): 705-6.
Taba e nepahetseng: Boitsebiso bo boletsoeng setšeng sena bo reretsoe merero ea thuto feela 'me ha bo nkele sebaka keletso, ho hlahlojoa kapa kalafo ke ngaka e nang le tumello. Ha e reretsoe ho koahela mekhoa eohle ea tlhokomelo, likamano tsa lithethefatsi, maemo kapa liphello tse bohloko. U lokela ho batla thuso ea meriana hang-hang bakeng sa bophelo bo botle le ho buisana le ngaka pele u sebelisa mefuta e meng ea phekolo kapa u etse phetoho tsamaisong ea hau.