Liphuputso Fumana Kopano e Khonehang pakeng tsa Statins le Inflammation
Liphuputso li fumane liphello tse molemo tsa li-statins , ho kenyelletsa kamano pakeng tsa li-statin le ho ruruha .
Bothata ke eng?
Ho ruruha ke karolo ea karabelo e tloaelehileng ea 'mele ho kotsi kapa tšoaetso. Ha o fumana kotsi e nyenyane (ho senyeha kapa ho khaola), sebaka se potolohileng eona se khutlela mantsiboea ebe sea ruruha hanyenyane. Tsena ke matšoao a kantle a ho ruruha, matšoao a 'mele a bokellang ha a tobane le tšenyo.
Ke karolo ea tlhaho ea mokhoa oa ho folisa. Empa hase kamehla ho thusang.
Ho ruruha ho etsahala ha tsamaiso ea 'mele ea' mele ea ho itšireletsa mafung e romella lisele tse khethehileng tsa mali tse tšoeu sebakeng se senyehileng. Lisele tsena li thusa ho loantša tšoaetso leha e le efe le ho hloekisa lisele tse shoeleng tse setseng. Mokhoa o ts'oanang o etsoang ka ho khaola, ho longoa kapa ho otloa ho boetse ho etsahala ka likotsi ho mesifa kapa methapo ea pelo.
Mosebetsi oa LDL Cholesterol ka ho ruruha
Ka mokhoa o ts'oanang, 'mele o romela masole a tšosang a tsamaiso ea' meleng ho isa libakeng tse chesang tsa mongobo - ke hore, plaques e entsoeng ke cholesterol e mpe ( LDL ) ka marako a methapo. Ka bomalimabe, ha macrophages e nka lipoleiti tsena, li ka kenngoa ka k'holeseterole 'me li qetella li phaella ka lekaneng le ka kakaretso. Le hoja ho ne ho reretsoe ho loantša letlapa, karabo ea ho ruruha e hlile e etsa hore plaque e se ke ea tsitsa 'me e atisa ho fela,' me seo se ka fella ka lefu la pelo kapa ho otloa ke pelo.
Ho phaella moo, ho ruruha ka pelong le methapo ea mali ho etsa hore marako a sekepe a mali a be "sticky" 'me a atisa ho hohela lisele tse ling tsa mali le k'holeseterole, e etsang sekontiri, kapa likoti holim'a li-deposit deposits tse seng li le teng. Qetellong, mokhoa ona o ka thibela ho phalla ha mali le oksijene.
Haeba mothapo o ammeng o fana ka pelo kapa boko, hape, phello e ka ba lefu la pelo kapa stroke .
C-Reactive Protheine ea ho ruruha
Ha ho ruruha ho teng kae kapa kae 'meleng, liprotheine tse khethehileng li lokolloa ka mali a ka fumanoang ka liteko tsa mali. Liteko tse ling, tse kang tekanyo ea erythrocyte sedimentation (ESR, kapa "sed rate") ke litekanyo tse akaretsang tsa ho ruruha. Protheine ea C-reactive (CRP) ke tekanyo e 'ngoe ea ho ruruha kapa tšoaetso' meleng. Lipalo tsa CRP tse fetang 10 mg / L ke pontšo ea hore ho ruruha ho teng kae-kae 'meleng. Leha ho le joalo, ha CRP e phahame ka bonolo, pakeng tsa 1 mg / L ho 3 mg / L, e tlameletsoe ho mathata a pelo ea methapo ea pelo, e leng pelo le methapo ea mali.
Le hoja maemo a phahameng a CRP ke karolo ea karabelo ea tlhaho ea matšoenyeho, e boetse ke litaba tse mpe. Ba ka bolela esale pele lefu la pelo ho batho ba e-s'o ka ba ba le eona pele. Tabeng ea bakuli ba nang le mekhoa e meng ea pelo - ho akarelletsa le angioplasty , ho behoa ka mokhoa o tsitsitseng, le ho beha methapo ea mali e lekaneng - le ba nang le lefu la sefuba se amanang le pelo - angina e tsitsitseng kapa angina e sa tsitsang - litekanyetso tse phahameng tsa CRP li 'nile tsa amahanngoa le kotsi e eketsehileng bakeng sa tlhaselo ea pelo kapa stroke le monyetla o moholo oa lefu.
Ka lehlakoreng le leng, ho thibela ho ruruha ho thusa batho ba kotsing ea lefu la pelo. Lintho tse bohlokoa tsa lefu la pelo li kenyelletsa khatello e phahameng ea mali , lefu la tsoekere , k'holeseterole e phahameng, ho tsuba kapa histori ea malapa a pelo.
Litemoso li etsa'ng ka ho ruruha le ho fokotsa litekanyetso tsa CRP?
Litemana ke sehlopha sa bohlokoa sa meriana e fokolang mahlaseli a kotsi a k'holeseterole e mpe. Litokomane li thusa ho thibela maloetse a pelo, ho otloa ke lefu le kotsi e ling e amanang le k'holeseterole e mpe haholo (LDL) maling. Ka boikokobetso ba phahamisa k'holeseterole e ntle ea mali ( HDL ). Litokomane li sebetsa ka ho thibela enzyme e bitsoang HMG-CoA reductase e bohlokoa bakeng sa ho etsa k'holeseterole e mpe ho tsoa mafura a tletseng lijo.
Ntle le ho fokotsa maemo a mabe a k'holeseterole e mpe, li-statins li boetse li thusa ho theola maemo a mali a CRP. Le hoja phello ea k'holeseterole e utloisisoa hantle, mekhoa ea ho fokotsa CRP le ho ruruha ha e tsejoe hantle. Bo-rasaense ba lumela hore li-statin li thibela liprotheine le lisele tsa 'mele tsa' mele tse lokolotsoeng e le karolo ea mokhoa o tloaelehileng oa ho ruruha ha 'mele. Ho fokotsa liprotheine tsena ho thibela ho ruruha hore ho se ke ha etsahala.
Hape ho bonahala hore tšebeliso ea nako e telele ea li-statine e fella ka ho ruruha ho seng kae pelong le mathata a fokolang. Liphuputso tsa bakuli ba sebetsang ka angioplasty ka pontšo e tsotehang ea hore ba neng ba nka li-statins pele ho ts'ebetso ena ba ne ba e-na le maemong a tlaase a CRP ka morao 'me ba ne ba se na monyetla oa hore ba hlaseloe ke pelo kapa ba shoe selemo se seng ka mor'a mokhoa ona.
Liphuputso tsa bakuli ba nang le likoti tsa senyesemane li fumane hore ka nako e khutšoanyane le ho fihlela ho 1 selemo ka mor'a ho otloa, bakuli ba nkang li-statins ba na le maemo a tlase a CRP le liphello tse ntlafetseng. Melemo ena e ne e kenyeletsa mathata a fokolang a methapo ea pelo, joalo ka lipuo le mathata a tsamaiso. Hape ho ne ho boetse ho e-na le lefu le fokolang la lefu selemong se latelang ka lefu la stroke. Ho phaella moo, li-statins li fokotsa kotsing ea ho ba le tšoaetso ea lefu ho batho ba kileng ba e-ba le ketsahalo e boima ea liketsahalo, tse kang lefu la pelo.
Feela joalokaha ho ba teng ha CRP maling ho ka bolela esale pele mathata a pelo, ho theola likarolo tsa CRP ho fokotsa likotsi tsa pelo tsa tlhaselo ea pelo kapa liketsahalo tse ling tsa lefu la pelo, ho akarelletsa le stroke. Le hoja mokhoa o tobileng o ntse o sa hlaka, bo-rasaense ba thehile maqhama a hlakileng pakeng tsa li-statins le ho theola maemo a CRP. Ho feta moo, lipatlisiso li bontša hore molemo o moholo ka ho fetisisa oa ho nka li-statins ke oa batho ba qalang ka maemo a phahameng a CRP; melemo ena ha e nahane feela ka liphello tsa lik'holingolole feela.
Ke habohlokoa ho hopola hore ho theola likhutsana tsa CRP le li-statins ha ho lekaneng ka boeona ho thibela lefu la pelo. Le hoja maemong a tlase a CRP a le molemo, ntho e 'ngoe le e' ngoe e bakoang ke lefu la tsoekere, e kang lefu la tsoekere, khatello e phahameng ea mali , ho tsuba, botenya le / kapa k'holeseterole e phahameng - e tlisa mafu a pelo 'me e phahamisa kotsi ea ho ba le lefu la pelo kapa leqeba. Tsela e molemo ka ho fetisisa ea ho qoba liketsahalo tsena ke ho ikoetlisa, ho latela lijo tse phetseng hantle, tse fokolang mafura le ho noa meriana e laetsoeng joaloka khothaletso ea mofani oa tlhokomelo ea bophelo ho thusa ho fokotsa likotsi tsa hau ka hohle kamoo ho ka khonehang.
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