Tlhahlobo ena e lemoha li-autoantibodies tse thusang ho netefatsa hore na ho fumanoa eng
Tlhahlobo ea anti-CCP e sebelisetsoa ho bona li-autoantibodies le thuso ho khetholla pakeng tsa ramatiki le mafu a mang a ho ruruha a ramatiki . Antibody ea cyclic citrullinated peptide (CCP) ke autoantiane khahlanong le liprotheine tse hlaselitsoeng (ACPA) 'me e lekantsoe ke teko ena.
Tlhahlobo e na le kutloisiso e phahameng haholo ea ramatiki ea ramatiki , eo ho thoeng e pakeng tsa 50 le 75 lekholong.
E boetse e na le boemo bo phahameng ka ho fetisisa bakeng sa ramatiki ea lefu la masapo a etsang karolo ea 90 lekholong. Tlhaloso ea eona e phahameng ke hore tlhahlobo ea anti-CCP e fetohile karolo ea bohlokoa ea ts'oaetso ea lefu la ramatiki.
Tlhahlobo ea Test-Anti-CCP le Boemo ba Prognostic
Ntle le ho thusa ho khetholla pakeng tsa ho ruruha ha ramatiki , tlhahlobo ea anti-CCP e boetse ke ea bohlokoa haholo ha ho fumanoa batho ba seronegative bakeng sa lefu la ho rama . Hase feela hore tlhahlobo ea anti-CCP e na le tekanyo ea ho hlahloba (ho lekanyetsa hore na ke boemo bofe boo u nang le bona), hape bo na le bohlokoa ba ho bolela (ho bolela esale pele boemo ba boemo ba hau).
Haeba anti-CCP e le teng ka mokhoa o itekanetseng ho ea holimo, ha e thuse feela ho netefatsa hore na ho fumanoa eng, e fana ka maikutlo a hore ho ka 'na ha e-ba kotsi e kotsi le e matla haholo ea mafu, e kang tšenyo e kopanetsoeng e kopaneng. Maemong a tlase a anti-opione ha a bolele kapa a bolela esale pele.
Hangata, tlhahlobo ea anti-CCP e laeloa hammoho le teko ea bokooa ba lefu la tšoaetso, kaha ha ho le teko feela e ka tiisang hore ho na le lefu la ramatiki la lefu la rumatoid.
Ho ea ka setsebi sa rheumatologist Scott J. Zashin, "Le hoja ho na le ntho e tloaelehileng ho batho ba nang le lefu la ramatiki, ho na le batho ba nang le tšoaetso ea lefu la masapo a sa tšoaneng a nang le lefu la masapo. Ho feta moo, boteng ba rumatoid bo na le bohlokoa bo fetisisang ho feta ACPA.
Hape, haeba motho a e-na le tšusumetso e mpe ea lefu la tšoaetso ea mafu, ha ho bonolo hore a be le boikutlo bo nepahetseng bakeng sa ACPA. "
Ho khetholla li-Autoantibodies
Bohlokoa ba ho khetholla li-autoantibodies mafu a li- rheumatic bo ne bo tsejoa ka lilemo tse mashome, empa ho khetholla tse neng li le bohlokoa holima lits'ebeletso tse khethehileng le ho nka kutloisiso ho nka nako. Ho bile le meloko e meraro ea tlhahlobo ea anti-CCP. Ho na le moloko o mong le o mong oa ho hlahloba taba e tobileng le kutloisiso e ntlafetseng.
Ho ea ka "Kelley's Textbook of Rheumatology," batho ba fetang karolo ea 90 lekholong ba nang le ramatiki e sa amaneng le ba bang ba nang le tšoaetso e ntle ea anti-CCP ba hlahisa lefu la ramatiki ka mor'a lilemo tse tharo. Ke karolo ea 25 lekholong feela ea ba nang le ramatiki e sa amaneng le ba bang ba nang le tšoaetso e mpe bakeng sa anti-CCP ho hlahisa ramatiki ea mafu.
Li-autoantibodies li ka 'na tsa e-ba teng pele ho kula ha mafu a mang a mangata, ho akarelletsa le lefu la ramatiki. Li-autoantibodies li ka etella pele ho qaleha ha ramatiki ea lefu la ho ruruha hamonate ka lilemo tse peli ho isa ho tse tšeletseng, ho ea ka "Kelley's Textbook of Rheumatology." Ho tlalehoa, ho loantšana le anti-CCP pele ho lefu la ramatiki la lefu la rumatoid le tloaelehile ka makhetlo a mabeli ho feta lekhetlo la pele le fumanoang ke lefu la lefu la tšoaetso.
Le hoja bothata ba lefu la rheumatoid hangata bo lula bo le teng, ho ba teng ha anti-CCP ho ka fapana le bakuli ba ramatiki ea lefu la masapo-esita le ho nyamela maemong a mang.
Bohlokoa ba Anti-CCP
Bafuputsi ba tsoela pele ho sheba se etsahalang 'meleng ho hlahisa limolek'hule (li-antigens) tse bakang tlhahiso ea likokoana-hloko tsena tsa anti-CCP. Li bitsoa autoantigens hobane li hlahisoa ke ho senyeha ha likarolo tsa 'mele ho e-na le ho tsoa ka ntle ho' mele. Li-enzyme tsa Peptidylarginine deiminase (PAD), tse susumetsang phetoho ea peptidylarginine ho peptidylcitrulline, li na le karolo ea bohlokoa ho hlahisang li-autoantigens ka ramatiki ea lefu la rumatoid.
Hape, ho etsa lipatlisiso tse eketsehileng ho fumana hore na ke eng e bakang karolo ea pele ho tšoaetso ea ramatiki ea lefu la ho ruruha ho fetola tšoaetso ea matšoao a tšoaetsanoang.
Le hoja anti-CCP e hlakile ka ho fetisisa bakeng sa ramatiki ea lefu la masapo, liphello tse ntle li ka hlaha ka mafu a mang a bakoang ke lefu la lefu, lefuba le lefu le sa foleng la matšoafo. Li-antibodies tsa Anti-CCP li tlalehile ka systemic lupus erythematosus le lefu la mantlha la Sjogren , hangata ha ho na le ramatiki e matla. E fumanoe hape ho batho ba etsang karolo ea 16 lekholong ba nang le ramatiki ea psoriatic -hangata ka ho phekola kapa polyarthritis . Ka linako tse ling, e tsamaea le psoriasis e matla ntle le ramatiki.
> Mehloli:
> Cush JJ, Kavanaugh A, Weinblatt ME. Ramatiki ea Ramatiki: Tlhahlobo ea Pele le Phekolo . Bophirimela Islip, NY: Professional Communications; 2010.
> Firestein GS, Kelley WN. Kelleys Textbook ea Rheumatology . Philadelphia, PA: Elsevier / Saunders; 2013.
> Taylor PC, Nete ea RN. Li-Biologic Markers ho Tsejoang le Tlhahlobo ea Ramatiki ea Ramatiki. E maemong. https://www.uptodate.com/contents/biologic-markers-in-the-diagnosis-and-assessment-of-rheumatoid-arthritis.