E 'ngoe ea Liteko tsa Pele li Laetsoe Ha Ramatiki ea Rheumatoid e Lebelloa
Tlhahisoleseding ea lefuba ke autoantibody (hangata IgM) e tlamang sebakeng sa Fc sa li-antibodies tsa IgG. Li-antiantibodies ke liprotheine tse hlahisoang ke tsamaiso ea ' mele ea ho itšireletsa mafung , empa ho e-na le ho hlasela lintho tse tsoang linaheng tse ling, li hlasela litho tsa' mele. Haeba ngaka ea hao e belaela hore u ka ba le ramatiki ea lefuba , tlhahlobo ea lefu la tšoaetso e tla ba e 'ngoe ea liteko tsa pele tse hlahlojoang.
Litlhahlobo tsa pele-pele (liteko) tse bontšang hore li-autoantibodies li ne li amahanngoa le ramatiki ea ramatiki e ile ea hlahisoa lilemong tsa bo-1940. Qalong, tsena e ne e le liteko tsa mafu a mangata moo ho bonahalitsoeng hore serame e tsoang ho bakuli ba ramatiki ea lefu la masapo e bakoa ke lefu la lisele tse khubelu tsa mali tse neng li hlokomelisitsoe le mebutlanyana e khahlanong le linku tsa 'mele. Ho ne ho e-na le liphetoho tse 'maloa tse entseng tlhahlobo ea tlhaho ea agglutination, haholo-holo ho kenya likhahla tse entsoeng ka IgG bakeng sa lisele tsa linku. Qetellong, tlhahlobo ea lefu la rumatoid e ile ea ntlafatsoa ke ELISA (e-enzyme e amanang le immunosorbent assay), hammoho le liteko tsa nephelometry.
Litekong tsa agglutination, ho bokella ho bonts'a sephetho se setle. Li-dilutions tsa li-serial li ka etsoa ka sampuli ea tlhahlobo ho fumana hore na sehlooho se joang. Letšoao le bontša hore na sampula e ka hlakisoa hakae pele setho sa matšoafo se sa bonahale (ha se fokotsehe).
Litlhahlobo tsa nephelometry, sesupa-mali ea mali e kopantsoe le li-antibodies tse bakang clumping.
Leseli le fetisoa ka sampuli ho fumana hore na boemo ba cloudiness bo bokae.
Ho utloisisa Litholoana
Ka tloaelo, litekanyo tse tloaelehileng bakeng sa teko ea bokooa ba lefu lena li tlalehoa e le:
- Ka tlaase ho 40-60 u / mL
- Ntle ho 1:80 (titer)
Tlhokomeliso: Li-laboratori tse fapaneng li ka fapana ka mokhoa oa teko kapa lisebelisoa tsa tlhahlobo tse sebelisoang, kahoo latela mekhahlelo le mefuta e tloaelehileng e fanoang ke laboratori ea hau.
Liphello tsa liteko tsa lefu lena li ka ferekanya bakuli ba ramatiki. Ntho ea bohlokoa ka ho fetisisa, ntho ea bohlokoa ka ho fetisisa eo u lokelang ho e tseba ke hore tlhahlobo ea lefu la tšoaetso ke karolo e le 'ngoe feela ea boitsebiso bo sebelisetsoang ho etsa hore motho a hlahlojoe. Tlhahlobo e hlakileng ha e mohla e thehiloe feela ka lebaka la teko ea lefu la bokooa. Mona ke lintlha tse ling tsa bohlokoa mabapi le teko ea bokooa ba lefu lena eo u lokelang ho e tseba:
- Bothata ba lefu la tšoaetso bo ka ba le tšusumetso ho batho ba phetseng hantle (ho 1% ea batho ba bacha le ho fihlela ho 5% ea ba fetang lilemo tse 70).
- Matšoao a lefu la tšoaetso a ka ba le tšusumetso ho maloetse a mangata a sa tšoaroeng ke ramatiki le maemo (mohlala, tšoaetso, lefu la kankere) kapa maemong a rheumatic ntle le ramatiki ea rhumatori (mohlala, Sjogren's syndrome kapa lupus ).
- Tlhahlobo ea lefu lena e ka fumanoa maling ho fihlela ho lilemo tse 10 pele matšoao a ramatiki a lefuba a hlaha. Leha ho le joalo, sehlopheng se le seng sa bakuli ba ramatiki ea lefu la masapo, lefu la rumatoid lea fumanoa ka mor'a hore matšoao a hlahe.
- Batho ba nang le ramatiki ea lefu la masapo ba nang le tšoaetso ea lefu la ho ramahanngoa (e leng li-seropositive) ba atisa ho ba le maloetse a mangata, athe bakuli ba nang le tšoaetso ea lefuba (seronegative) ba na le maloetse a seng makae le ho fokotseha ha masapo.
- Batho ba etsang karolo ea 20 lekholong ba fumanoeng ba e-na le ramatiki ea lefu la tšoaetso ba ntse ba e-na le tšoaetso ea letho bakeng sa lefu lena.
Tlhahisoleseding ea Meriana ea Boipheliso
Phello ea liteko tsa lefu la tšoaetso ea mali e ka 'nang ea e-ba le mathata hamorao e ka fetoha e ntle, empa bohlokoa ba kliniki ba taba eo bo ntse bo le teng. Ho ea ka Scott Zashin, MD, rheumatologist ea Dallas, Texas (scottzashinmd.com) le mongoli oa Arthritis ntle le bohloko - Mohlolo oa TNF Blockers le moqapi oa buka ea ka ea bobeli ea Natural Arthritis Treatment , "Rheumatologists hangata ha e latele rheumatoid factor hang ha ho fumanoa lefu la ramatiki la mafu a mafu . Ho boleloa hore, ka phihlelo ea ka, boemo ba rumatoid bo ka fetoha ka mokhoa o itseng oa lefu lena , empa ha se thuso ea meriana ho feta liteko tse ling, tse kang tekanyo ea erythrocyte sedimentation , C- protheine e nang le matla a mangata (CRP) , 'me maemong a mang ho na le lisebelisoa tse ling tse ka fumanoang litekong tsa VECTRA , tse sebelisetsoang ho hlahloba mafu a lefu la ramatiki. "
Lisebelisoa:
Kelley's Textbook ea Rheumatology. Khatiso ea Borobeli. Autoantibodies ka Rheumatoid Arthritis. Khaolo ea 56. Felipe Andrade et al. p. 804.
Primer ka Rheumatic Diseases. Khatiso ea Bo13. E phatlalalitsoe ke Arthritis Foundation. Khaolo ea 6. Rheumatoid Arthritis. Li-Rheumatoid Factors. p. 126.
Rheumatoid Factor (RF). MedlinePlus. E hlalositsoe 4/20/2013.
https://www.nlm.nih.gov/medlineplus/ency/article/003548.htm