Truvada ke pilisi e le 'ngoe, tekanyo e tsitsitseng ea lithethefatsi e nang le li-antiretroviral tse peli, tenofovir le emtricitabine, tse peli tse khetholloang e le nucleotide reverse transcriptase inhibitors. Likarolo tse peli tsa lithethefatsi li rekisoa ka boithaopo e le Viread (tenofovir) le Emtriva (emtricitabine, FTC).
Truvada e ile ea amoheloa ke US Food and Drug Administration (FDA) ka August 2004 bakeng sa tšebeliso ea HIV , haholo-holo ho batho ba baholo le bana ba fetang lilemo tse 12 ba boima ba lik'hilograma tse 35 kapa ho feta.
Hamorao Truvada e ile ea fuoa tumello ea FDA ka July 2012 bakeng sa ho thibela tšoaetso ea HIV ho batho ba kotsing haholo ka leano le bitsoang pre-exposure prophylaxis (PrEP) .
Ho thehoa
Letlapa le entsoeng ka kopi e nang le 300mg tenofovir diisopropyl fumarate le 200mg emtricitabine. Letlapa le leputsoa, le selelele ke filimi e koahetsoeng le e koahetsoeng ka lehlakoreng le leng ka palo "701" 'me e' ngoe e e-na le lebitso la moetsi "GILEAD."
Tekanyo
- Bakeng sa bakuli ba nang le kokoana-hloko ea HIV: hlapa e le 'ngoe letsatsi le leng le le leng, ba nkoa ka molomo kapa ba se na lijo
- Ho sebelisoa e le PrEP: letlapa le leng le le leng letsatsi le leng le le leng, le nkiloe ka molomo kapa le se na lijo.
- Bakeng sa bakuli ba nang le ts'oaetso ea liphio: ho hlahisoa letlapa le leng le le leng lihora tse 48 haeba letlalo la creatinine le pakeng tsa 30-49mL / motsotso. Haeba o ka tlase ho 30mL / metsotso kapa ka hemodialysis, u se ke ua e sebelisa .
Litaelo
Bakeng sa bakuli ba nang le kokoana-hloko ea HIV, Truvada e tlameha ho nkoa ka meriana e meng ea li-antiretroviral.
Ha e sebelisoa e le PrEP, Truvada e nkoa e le eona mokhoa oa ho thibela HIV, o akarelletsang likhohlopo le mekhoa e meng e sireletsehileng ea thobalano.
Liphello tse Tloaelehileng
Litla-morao tse tloaelehileng tse amanang le tšebeliso ea Truvada (e etsahalang ka 5% kapa ka tlaase ho linyeoe) li kenyelletsa:
- Nausea
- Letšollo
- Mokhathala
- Sinusitis
- Hlooho ea hlooho
- Sehlōhō
- Ho tepella maikutlong
- Rash
Litlhōlisano
Ka molao, tekanyo leha e le efe e tsitsitseng e kopantseng lithethefatsi e nang le tenofovir, emtricitabine kapa lamivudine (e leng lithethefatsi tse ling tsa NRTI tse tšoanang le emtricitabine) ha lia lokela ho nkoa ka Truvada.
- Matšoao a meriana a khahlanong le HIV: Atripla (tenofovir + emtricitabine + efavirenz), Combivir (Retrovir + lamivudine), Complera (tenofovir + emtricitabine + rilpivirine), Emtriva (emtricitabine, FTC), Epivir (lamivudine, 3TC), Epzicom (abacavir + lamivudine) , Stribild (Tenofovir + emtricitabine + elvitegravir + cobicistat), Triumeq (abacavir + lamivudine + dolutegravir), Trizivir (Retrovir + abacavir + lamivudine), Viread (tenofovir)
- Meriana ea Hepatitis B: Hepsera (adefovir)
Likamano
Ebisa ngaka ea hau haeba u nka e 'ngoe ea tse latelang:
- Li-Anticoagulants: Lixiana (edoxaban), Pradaxa (ho feta)
- Meriana ea kankere e seng e nyenyane-ea lefuba: Ofev / Vargatef (nintedanib)
Litlhahlobo tsa Kalafo
Truvada e lokela ho sebelisoa ka tlhokomelo ho bakuli ba nang le histori ea ho fokola ha liphio (liphio). Kamehla hlahloba ho lefshoa hoa pele ho tlhaho pele u qala kalafo. Bakeng sa bakuli ba nang le kotsing ea ho se sebetse hantle, ba kenyeletsang ho tlosoa ha li-creinine, serum phosphorus, popo ea urine le protheine ea moroto nakong ea ho hlahloba.
Tlhokomelo e lokela ho nkoa ha ho sebelisoa Truvada le Videx ea antiretroviral ea HIV (didanosine). Le hoja mekhoa ea ho sebelisana e sa tsejoe, liphuputso li bontšitse hore khoebo ea khoebo e ka eketsa mohopolo oa serame oa Videx le ho eketsa menyetla ea liketsahalo tse mpe (mohlala, pancreatic, neuropathy).
Ho khothalletsoa hore Videx e fokotsehe ho 250mg ho bakuli ba boima ba lik'hilograma tse 60 (60kg) kapa ho feta.
Dintlha tse fumanoang ke batho le liphoofolo li bontša hore Truvada ha e eketsa kotsi ea ho holofala nakong ea bokhachane . Leha ho le joalo, hobane liphello tsa tenofovir le emtricitabine ho lesea ha li tsejoe, bo-'mè ba eletsoa hore ba se ke ba anyesa haeba ba nka Truvada.
Lisebelisoa:
US Administration of Drug and Drug Administration (FDA). "FDA e lumellana le meriana e 'meli e tsitsitseng-likokoana-hloko bakeng sa phekolo ea tšoaetso ea HIV-1." Silver Spring, Maryland; tokomane ea khatiso e fanoeng ka la 2 August, 2004.
FDA. "FDA e amohela lithethefatsi tsa pele ho fokotsa kotsi ea tšoaetso ea HIV." Silver Spring, Maryland; tokomane ea khatiso e fanoeng ka la 16 July, 2012.