Angiotensin e fetola enzyme (ACE) inhibitors ke meriana ea molomo e fokolang khatello ea mali. ACE inhibitors e sebelisetsoa ho phekola khatello ea kelello ea mali (khatello ea mali e phahameng), lefu la methapo ea pelo le ho hloleha ha pelo, le ho thusa ho laola tsoelo-pele ea lefu la tsoekere le lefu la liphio.
Kakaretso
Mekhoa ena ea mafu e atisa ho tsamaea ka letsoho; khatello e phahameng ea mali e tloaelehile har'a batho ba nang le lefu la tsoekere.
Matšoao a phahameng a mali a boetse a tlatsetsa tabeng ea ntshetsopele ea lefu la lefu la tsoekere (lefu la liphio).
Ho feta moo, ba nang le lefu la tsoekere ba atisa ho ba le liphello tse mpe (ho fumana li-hospitali tse telele, nako e telele ea ho hlaphoheloa le likotsi tse phahameng tsa tšoaetso) ho tloha mathateng a maholo a pelo. Ka hona, bafani ba tlhokomelo ea bophelo bo botle ba tšoara khatello ea meriana ka kakaretso le lefu la tsoekere .
Le hoja ACE inhibitors ha e fokolise tsoekere ea mali ka ho toba, e ka tlatsetsa ho laola tsoekere ea mali ka ho eketsa kutloisiso ea 'mele ho insulin. Insulin e thusa 'mele hore o be le metsoako ea tsoekere (tsoekere) ebe o e tlosa ho tloha mali ho ea lisele, moo e sebetsang e le mohloli oa matla.
Ba bangata ba ACE inhibitors ba teng United States, ho akarelletsa Capoten (captopril), Prinivil le Zestril (lisinopril), Vasotec (enalapril), Lotensin (benazepril), Altace (ramipril), Accupril (quinapril), Monopril (fosinopril), Mavik ( trandolapril), Aceon (perindopril) le Univasc (moexipril).
Kamoo ba Sebetsang Kateng
ACE inhibitors khatello ea mali ea mali ka ho thibela 'mele ho hlahisa hormone angiotensin II. Angiotensin II e bakisa vasoconstriction (ho fokotsa methapo ea mali) le ho boloka metsi, ho fella ka khatello ea meriana. Ka ho fokotsa khatello ea mali le ho boloka metsi, ACE inhibitors e thusa ho laola pelo ho hlōleha.
ACE inhibitors e ka boela ea thibela le ho laola lefu la tsoekere (mafu a liphio) le ho thusa ho laola retinopathy (mathata a mahlo). ACE inhibitors ha e liehe ho otla pelo kapa ts'oaetso e tlaase ea mali.
Histori ea Sebeliso
ACE inhibitors e amohetse FDA bakeng sa phekolo ea mokuli oa meroalo ho tloha ka 1981. Ka nako e telele, tšebeliso ea ACE inhibitor e atolositse haholo ho phekola mafu a pelo le maemo a amanang.
Ke Mang ea Lokelang ho Qoba
Batho ba nang le khatello e tlaase ea mali (hypotension), kapa ba nang le menyetla kapa meno e amanang le ACE inhibitors, ha baa lokela ho sebelisa ACE inhibitors. Hape batho ba nang le methapo ea renal stenosis ha baa lokela ho ba joalo, bakhachane le basali ba lekang ho emola.
Batho ba nang le tšenyo e khōlō ea liphio ba hloka hore ho be le phetoho e fetotsoeng ea ACE inhibitors.
Litla-morao le Likotsi
Meriana eohle ea khatello ea mali e beha kotsing ea ho itšoara hantle, le matšoao a kenyeletsang ho ba le bohlooho bo botle, ho ba le botenya, ho nyefoloha, ho fufuleloa le ho lahleheloa ke kelello.
Hangata, ACE inhibitors e ka baka tsoekere e tlase ea mali (hypoglycemia). Sena se etsahala ho batho ba nang le lefu la ts'oaetso ba nang le tsoekere ea mali e sa laoloang hantle ke ho ja le meriana e meng ea antidiabetic.
ACE inhibitors e ka baka ho khohlela ho batho ba bang. Haeba sena se etsahala, ba lokela ho bua ka sena le bafani ba bona ba bophelo bo botle, ba ka nkang meriana e fapaneng ea khatello ea mali.
Lisebelisoa tse ling tsa 'Off-Label'
ACE inhibitors e ka thusa ho thibela ho qala ha mofuta oa lefu la tsoekere oa mofuta oa 2 . Ho phaella moo, ACE inhibitors e ka thusa ho laola mekhoa e sa tloaelehang ea pelo, haholo-holo ha e sebelisoa ka mor'a lefu la pelo.
ACE inhibitors e sebelisoa ho tloha kalafo ea mafu a kang lefu la ramatiki, migraines, ts'oaetso ea Raynaud le lefu la Bartter.
Litlhahiso tsa Bophelo
Li-Angiotensin receptor blockers (ARBs) li tšoana le ACE inhibitors. Batho ba lekanang le ACE inhibitors kapa ba hlaolelang khohlela e amanang le ACE inhibitors ba ka atisa ho fetohela ho ARB ka phello e ntle. Batho ba nang le lefu la ts'oaetso ba lokela ho bolella bafani ba bona ka bophelo bo bong ka meriana e meng le e mengata, hammoho le litlama leha e le life tse sebelisoang hona joale, pele ba qala ho nka li-inhibitor tsa ACE.
Batho ba ACE inhibitors ba lokela ho hlahloba bafani ba bona ba bophelo pele ba qala meriana e mecha.
Lisebelisoa:
Bakris, George L. "Phekolo ea Kelello ea Mafu a Mafu a Lefu la tsoekere Mellitus." UpToDate.com. Dec. 11, 2015. Phetolelo .. (ho ngolisa).
Kaplan, Norman M., le Burton D. Rose. "ACE Inhibitors ho Phekolo ea Hypertension." UpToDate.com. 2014. UpToDate. (ho ngolisa)
McCulloch, David K., le R. Paul Robertson. "Ho Boleloa Pele le Thibelo ea Mofuta oa 2 oa Lefu la tsoekere Mellitus." UpToDate.com. 2007. UpToDate. 7 Sep. 2007 (ho ngolisa).