Ithute ho eketsehileng ka mefuta ea Paenibacillus e fokolang VT 400
Lehlabuleng la 2016, kopanong ea selemo le selemo ea American Society for Microbiology, bo-rasaense ba bokane ho arolelana le ho tšohla liphihlelo tse amanang le lefats'e la libaktheria le bophelo bo botle ba batho.
E 'ngoe ea lintho tse fumanoeng, sehlopha se tlalehile liphatsa tsa lefutso, kapa liphatsa tsa lefutso tse feletseng, bakeng sa baktheria e bitsoang Peenibacillus mofuta oa VT 400 (PVT400). Likokoana-hloko tsena li ne li fumanoe pele ho matšoao a bakuli ba nang le lefu la acute lymphoblastic (ALL).
Boitsebiso bo qaqileng bo tsoang ho sena le lithuto tsa nakong e tlang bo tla thusa bo-rasaense hore ba ithute hore na libaktheria tsena li ka ba le karolo ho maloetse a batho, haholo-holo ho batho ba tšoeroeng ke lefu la lekoemia le nang le tšoaetso ea mali kapa matšoao a mali.
Pneumonia ho Batho ba Nang le Kankere
Pneumonia ke sesosa se ka sehloohong se bolaeang bakuli ba kankere ba nang le neutropenia, haholo-holo ba tšoeroeng ke kankere ea mali. Neutropenia ke palo e tlase ea neutrophils li-neutrophils tsa mali ke lisele tse tšoeu tsa mali tse bohlokoa ho thusa 'mele ho loantša tšoaetso .
Mafu a tlase a tšoaetsanoang ke mafu a tloaelehileng a tloaelehileng har'a bakuli ba kankere, 'me ho na le litlaleho tse bontšang hore bakuli ba 13 ho ea ho karolo ea 31 lekholong ea bakuli ba lefu la leukemia ba fumanoang ke chemotherapy' me karolo ea 80 lekholong ea hematopoietic stem cell transplant baeti ba tla ba le bonyane sekhetho se seng sa pneumonia.
Pneumonia ea Neutropenic e ka 'na ea e-ba tšoaetso e sokelang bophelo. Maemong a joalo, lingaka li qala kalafo ea lithibela-mafu hang-hang, ntle le ho emela liphetho tsa laboratory ho tiisa le ho bolela mofuta oa tšoaetso ea baktheria-hobane ke habohlokoa ho qala kalafo ka nako e le 'ngoe, ho fokotsa kotsi ea hore mokuli a fihle ho tšoaetso.
Ha e le hantle, phekolo ea thibelo e sebelisoa maemong a mang, a hlalositsoeng ka tlaase mona.
Khatelo-pele ea morao-rao tsamaisong ea pneumonia ea neutropenic e hlahisa tšepo ea liphello tse molemo. Mekhatlo e mengata ea bongaka e ntšitse pele tataiso e ncha ea phekolo ea lithibela-mafu ea ho belaelloa ka pneumonia ea neutropenic.
Hape ho ka etsahala hore mahlahana a macha a khothalletsang likarabo tsa 'mele ho tšoaetso a ka ntlafatsa mosebetsi oa lithibela-mafu.
Ho tsepamisa maikutlo ho likokoana-hloko ho bakuli ba nang le neutropenia
Litaelo tse tsoang ho American Society of Clinical Oncology (ASCO) li khothalletsa hore lingaka li leke ho thibela tšoaetso maemong a ka ntle ho neutropenia empa ha ho feberu. Kalafo ea antibacteria le ea maiketsetso e eletsoa haeba li-neutrophils li lebeletsoe ho lula ka tlase ho 100 / μL ka matsatsi a fetang a supileng. Tataiso e bolela hore moemeli ea khethiloeng bakeng sa phekolo ea thibelo ea antibacterial ke molomo oa fluoroquinolone, athe seo bakeng sa phekolo ea antifungal ke triazole ea molomo.
Bakuli ba nang le neutropenia ba ka 'na ba e- ba le mefuta e sa tšoaneng ea mafu a likokoana-hloko ho feta balekane ba bona. Ho ka ba molemo ho lingaka ho hlahloba moo libaktheria li hlahang teng ho bolela esale pele hore na ke lithibela-mafu life tseo ba ka 'nang ba li hanyetsa, mme ka hona ke mekhoa efe e ka atlehang ka ho fetisisa.
Mefuta ea Paenibacillus
Ho fihlela moo, bo-rasaense ba 'nile ba ithuta PVT400, libaktheria tse ncha tse arohaneng le mokuli oa kankere, e leng setho sa mofuta oa Paenibacillus-e leng lelapa la mefuta e mengata ea baktheria. Mefuta e sa tšoaneng ka hare ho sehlopha sena e 'nile ea aroloa ke mobu, metsi, limela, lebese le libaka tse ling.
Leha ho le joalo, mefuta ea Paenibacillus e ne e sa tsejoe hore e baka mafu a batho. .. ho fihlela litlaleho tsa morao-rao li bontšitse hore ho na le mefuta e meraro e fapaneng ea mefuta ea Paenibacillus ea mafu a batho.
Ka mor'a hore PVT 400 e arohane le masapo a mokuli a nang le lefu la leukemia le amang acute lymphoblastic , liphuputso tsa pele li ile tsa bontša ho tšoana hoa mefuta ena e ikarotseng le mefuta ea amylolyticus, e fumanoang ka lekhetlo le le leng la sefofane; Leha ho le joalo, ho fihlela joale, e sa ntse e le 'nete hore P. amylolyticus ha e fumanoe ho batho,' me lithuto tse ling li bontšitse phapang pakeng tsa baktheria ea VT 400 e fumanehang mokuli oa kankere le tse ling tse P.
mefuta ea amylolyticus.
Kahoo, ha bafuputsi ba hlahloba tsohle tsa genome tsa VT 400, ho ne ho e-na le liphuputso tse 'maloa tse thahasellisang. E ne e na le liphatsa tsa lefutso tse kenyang mekhoa ea ho thibela meriana ea chemotherapy , joaloka tunicamycin le bleomycin. Ba ile ba boela ba fumana liphatsa tsa lefutso bakeng sa lipompo tsa baktheria tse amanang le ho hanyetsa likokoana-hloko, hammoho le liphatsa tsa lefutso tse khonang ho hanyetsa lithibela-mafu, ho akarelletsa le vancomycin, fosmidomycin, tetracycline hammoho le lithethefatsi tse kang penicillin, kapa beta-lactams.
Bangoli ba thuto ena ea genome ba ile ba bolela hore sekhetho se feletseng sa genome sa Paenibacillus sp. VT 400 e tla thusa ho fumana karolo ea mefuta ea Paenibacillus ka maloetse a batho le ho fana ka leseli ka sebōpeho sa libaktheria tse tloaelehileng tse phelang ho bakuli ba nang le kankere ea mali.
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