Likokoana-hloko tse ling tsa Proton Pump li fumaneha ho feta-The-Counter
Meriana e tloaelehileng ka ho fetisisa ea meriana e sebelisoang ho phekola mafu a Gastroesophageal Reflux (GERD) ke proton pump inhibitors (PPIs).
Proton pump inhibitors ke ba fokolang acid. Lingaka li laela ma-PPI ho tšoara batho ba nang le maemo a mangata ho akarelletsa:
- Ho sithabela (lefu la reflux la gastroesophageal)
- Liso tsa mpa kapa mala
- Kalafo bakeng sa Helicobacter pylori
- Nako e feteletseng ea acid ( Zollinger-Ellison Syndrome )
Kamoo li-PPIs li sebetsang kateng
E 'ngoe ea mabaka a etsang hore proton pump inhibitors e behoa hangata ke hobane ba atisa ho fokotsa ho otloa ke pelo.
Mathata a hao a hlahisa acid e le ho thusa ho senya lijo e le hore ho be bonolo ho o cheka. Maemong a mang, asiti ena e ka halefisa kamore ea mpa ea hao le duodenum (lebitso la bongaka bakeng sa karolo e ka holimo ea mala a hao a manyenyane) e bakang ho tsuba le esita le liso.
Kampa e na le pompo, e bitsoang gastric acid acid, e hlahisang acid e ka mpeng. Li-PPI li thibela ho khutsuoa ha acid ka mpeng ka ho tlamella lipompo tsena. Ho fokotsa bongata ba mpa e ka thusa li-ulcers hore li folise le reflux ho fokotseha.
Ho fumaneha Meriana ea PPI
Mona ke li-PPI tse supileng tse fumanehang, tse ling ka holimo-le-'moho le tse ling ka lengolo la ngaka feela:
- Aciphex (Rabeprazole)
- Nexium (Esomeprazole)
- Prevacid (Lansoprazole) -e fumaneha ka holimo-ho-counter
- Prilosec (Omeprazole) -e fumaneha ka holimo-ho-ea
- Protonix (Pantoprazole)
- Dexilant (Dexlansoprazole)
- Zegrid (omeprazole / sodium bicarbonate) -e fumaneha ka holimo-le-'moho
Li-PPI Tlas'a GERD e Tšoaroang
Haeba ngaka ea hau e buella PPI bakeng sa ho laola GERD, mohlomong o ne a boetse a khothalletsa liphetoho tsa bophelo tsa bophelo joaloka ho lahleheloa ke boima ba 'mele (haeba ho feta boima ba' mele kapa bobebe), ho phahamisa hlooho ea bethe ea hau bosiu, le ho ja lihora tse peli ho isa ho tse tharo pele ho robala.
Hangata li-PPI li nkoa hang ka letsatsi metsotso e 30 ho isa ho e 60 pele ho lijo tsa hoseng, 'me li nkiloe libeke tse ka bang robeli, ka nako eo ngaka ea hau e tla hlahloba hore na u ikutloa joang. Haeba u ntlafetse, ngaka ea hao e ka fokotsa lethal dose kapa ea emisa meriana ea hau. Ka karabelo e itseng, ngaka ea hau e ka eketsa lethal dose ka makhetlo a mabeli ka letsatsi. Haeba o ntse o sa fumane phomolo bakeng sa GERD ea hau, ngaka ea hau e ka 'na ea u lebisa ho setsebi (gastroenterologist) kapa ho hlahloba hape lefu lena.
Phekolo ea PPI ha e reretsoe ho nkoa nako e telele, kahoo pakane ke ho e nka ka tekanyo e tlaase ka ho fetisisa e ka ntseng e nolofalletsa tsitsipano ea hao le ho thibela mathata a kang lisosa. Ke ka lebaka leo ho latellanang haufi le ngaka ea hao ho bohlokoa-kahoo morero oa tlhokomelo ka hloko o ka etsoa le ho fetoloa ha ho hlokahala.
Seo U Lokelang ho se Tseba Pele U nka PPIs
Ka 2012, FDA e ile ea fana ka temoso ho bareki ba sebelisang li-PPI ba ka kopanngoa le kotsi e eketsehileng ea tšoaetso, joaloka pneumonia, hammoho le letšollo le amanang le Clostridium difficile. Ho tšoaetsoa ke baktheria Clostridium difficile ho baka litsi, mahlaba a mpeng le feberu.
Ho phaella moo, li-PPI li amahanngoa le ho fokotsa matla a khalsiamo le kotsi e eketsehileng ea mafu a masapo (ho batho ba ntseng ba e-na le litekanyetso tse phahameng tsa li-PPI-e bolelang hangata ka letsatsi le selemo kapa nako e telele).
E boetse e amahanngoa le ho fokotsoa ho kenngoa ha magnesium meleng, kahoo ngaka ea hau e ka 'na ea hlahloba boemo ba hau ea magnesium nako le nako.
Lentsoe le Tsoang ho
Ho bohlokwa ho nka meriana leha e le efe, ho akarelletsa le proton pump inhibitors, tlas'a tataiso ea ngaka, le haeba e fumaneha ka holimo-le-ngoe. Sena ke ho etsa bonnete ba hore proton pump inhibitor e nkiloe ka tsela e nepahetseng le ka lebaka le nepahetseng-ho hlahloba hantle ho bohlokoa, kaha ho na le mathata a bophelo a mangata a ka etsisang GERD.
Lisebelisoa:
> American College of Gastroenterology. (June 2008). Mathata a tloaelehileng a GI Buka ea 1: Ho utloisisa tse ling tsa Meriana Hangata e ngotsoeng bakeng sa GERD & Ulcers.
> Johnson, T. (June 2014). Tsamaiso ea lijo le lithethefatsi tsa US: Sebeliso ea likokoana-hloko tsa proto Pump le kotsi ea mafu a fractures ho batho ba baholo.
> Katz, PO, Gerson, LB, Vela MF Litekanyetso tsa ho hlahlojoa le ho laola mafu a reflux ea mafu a mangata. Am J Gastroenterol. 2013 Mar; 108 (3): 308-28.
> Lanza, FL, Chan, FK, Quigley, EM, Likarabo tsa Parameters Komiti ea American College of Gastroenterology. Litaelo tsa thibelo ea mathata a seso a amanang le lefuba la NSAID. Am J Gastroenterol. 2009 Mar; 104 (3): 728-38.
> Tsamaiso ea Tsamaiso ea Lijo le Meriana ea US. (February 2012). Tlhaloso ea Tšireletso ea Meriana ea FDA: Moriana oa lefu la Clostridium difficile o ka amahanngoa le lithethefatsi tsa asiti tse bitsoang proton pump inhibitors (PPIs).