Hlahloba le setsebi sa hau sa mafu pele u nka Painkiller
Sheba hoo e batlang e le leha e le efe ea meriana ea khoebo 'me u ka fumana NSAID (e seng steroidal e khahlanong le ho ruruha lithethefatsi). Li-SASA, tse sebelisetsoang ho tšoara bohloko le ho ruruha, li tloaelehile hoo li atisang ho ba le sebaka sa bona sa lipapali tsa lithethefatsi. Ha e le hantle, tlhokomelo e hloka ho nkoa e le ho netefatsa hore batho ha ba nke NSAIDS ka mokhoa o phoso, haholo-holo hobane ho ka ba bonolo ho sebelisa lisebelisoa tse fetang tse 'maloa ho feta ho sebelisa lithethefatsi ho folisa bohloko le feberu ho tswa ho feberu kapa tse ling tse tloaelehileng ho kula.
Litšebeliso tse ling tsa li-NSAID li kenyelletsa ho tšoaroa ke hlooho, bohloko ba mesifa, mekhoa ea ho ilela khoeli le ho lopolla mahlaba le bohloko ba letsatsi le leng le le leng.
Batho ba nang le maloetse a nang le ho ruruha (IBD) ba hlaheloa ke bohloko le bohloko joaloka motho e mong le e mong. Ba bangata ba boetse ba utloa bohloko letsatsi le leng le le leng ka lebaka la maemo a mangata a mala a kang a ramatiki kapa litla-morao tsa lithethefatsi tse kang ho tšoaroa ke hlooho. Leha ho le joalo, tse ling tsa gastroenterologists li khothalletsa hore bakuli ba bona ba IBD ba lule hōle le li-NSAIDs. Lebaka la hore: NSAID e ka 'na ea e-ba le phello e mpe holim'a lefu la Crohn le lefu la ho bolaoa ke lefu la ulcerative.
Mesebetsi ea NSAID e sebetsa joang
Li-SASA li sebetsa ka ho thibela li-enzyme tse peli 'meleng: cyclooxygenase-1 (COX-1) le cyclooxygenase-2 (COX-2) . COX-1 e phetha karolo ea bohlokoa tsamaisong ea phepo ea lijo le COX-2 e phetha karolo ea mokhoa oa ho ruruha. Mosebetsi oa COX-1 ke ho laola lintho tse bitsoang prostaglandins tse sireletsang lesela la mpa ho tswa ho li-acids tse thusang ho cheka lijo.
The prostaglandins e entsoeng ke COX-2 e kopanya mokhoa oa ho ruruha le bohloko ba ho arabela.
Seo se bolelang ke hore le hoja li-NSAID li fokotsa potoloho ea ho ruruha le bohloko, li boetse li etsa hore tsamaiso ea lijo tsa 'mele e lahleheloe ke lintho tse ling tsa eona tse sireletsang. Sena se ka baka mathata a mangata ho batho ba seng ba ntse ba e-na le ho ruruha, kapa monyetla oa ho ruruha, ka tsela ea bona ea lijo.
NSAID le Lisoli
Esita le ho batho ba se nang li-IBD, li-NSAID li ka tlatsetsa lithong tse ka mpeng le karolo ea pele ea mala a manyenyane ( duodenum ). Li-SASA li ka baka ho ruruha le ho mpefala ho tsoa mali maling a manyenyane. Litsebi tse ling tsa ho itšireletsa li amehile ka hore li-NSAID li ka etsa hore IBD e tsoe ka ntle.
NSAIDs le IBD
Lipatlisiso mabapi le hore na li-NSAID li kenya letsoho ho matšoao a IBD li fapana, ho baka phehisano mabapi le tšebeliso ea bona har'a li-gastroenterologists. Bakeng sa sehlopha sa lithethefatsi tse bitsoang COX-2 inhibitors, hona joale ha ho bopaki bo bongata liphellong tsa bona ho batho ba nang le IBD. Lipatlisiso tse ling li bontša hore li-NSAID li ka ama karolo ea itseng feela ea batho ba nang le IBD, empa ho ke ke ha khoneha ho tseba hore na ke mang ea tla ameha le eo e seng eena. Ho 'nile ha nahanoa hore ho sebelisa COX-2 inhibitor, ho e-na le lithethefatsi tse nang le COX-1 le COX-2 inhibitor, li ka sebelisoa ka tlhokomelo ho bao IBD ea bona e neng e le tšepisong.
Batho ba nang le IBD ba lokela ho buisana le gastroenterologist ea bona pele ba nka li-NSAID, esita le tse fumanehang ka holim'a counter. Hape ke habohlokoa haholo ho etsa hore litho tsohle tsa sehlopha sa tlhokomelo ea mokuli li tsebe hore na li-NSAID li na le phello efe ho tsona tsa IBD.
Seo ba nang le IBD ba ka se etsang
Batho ba nang le IBD ba batlang ho phomola ka ho fetisisa ka ho fetisisa ho ka 'na ba lakatsa ho nahana ka acetaminophen.
Acetaminophen, e rekisoang ka tlas'a mabitso a mangata, ho akarelletsa le Tylenol, hase NSAID mme e ka ba khetho e ntle ho batho ba nang le IBD ba hlokang ho fokolloa bohloko. Mokhoa oa acetaminophen o sebetsang ho thibela bohloko ha o utloisisoe ka ho feletseng, empa ho nahanoa hore o kenyelletsa ho thehoa ha prostaglandins.
Kamehla u botse ho tlatsoa ha ngaka e ncha ea lithethefatsi, haholo-holo e sebelisoang ho laola bohloko. Hase setsebi se seng le se seng sa tlhokomelo ea bophelo se tsebang hore na ho ka etsahala joang hore ho be le khokahanyo pakeng tsa lipilisi le IBD Ha batho ba nang le IBD ba tla etsoa opereishene kapa mekhoa ea mekhoa e metle, ke habohlokoa hore u bue le gastroenterologist bakeng sa puisano mabapi le phomolo ea bohloko ho etsa bonnete ba hore u na le tlhahisoleseding ea morao-rao ka li-NSAID le hore na li sebetsa joang ho uena.
Ka tlase tafole ea NSAID e fumanoang ka lengolo la ngaka kapa ka holim'a counter. Hona ha ho na lethathamo le feletseng, ka hona ka kōpo kopana le setsebi sa meriana kapa ngaka bakeng sa ho ameha ka lithethefatsi tse khethehileng.
Di-anti-inflammatory drugs (non-steroidal) (NSAIDs)
| Lebitso la Mabitso | Lebitso la Sehlahahlaha |
| Advil, Excedrin IB, Genpril, Haltran, Ibuprin, Ibuprohm, Ibu-Tab, Midrin 200, Medipren, Midol IB, Motrin, Nuprin, Pamprin-IB, Rufen, Trendar | Ibuprofen |
| Aleve, Anaprox, Naprosyn | Sodium ea Naproxen |
| Amigesic, Anaflex 750, Marthritic, Mono-Gesic, Salflex, Salsitab, Disalcid | Salsalate |
| Anacin, Bayer, Bufferin, Ecotrin | Choline salicylate |
| Tšoara, Froben | Flurbiprofen Mantsoe |
| Apo-Keto, Orudis, Oruvail, Rhodis | Ketoprofen |
| Apo-Sulin, Clinoril, Novo-Sundac | Sulindac |
| Aspergum, Bayer ea sebele, Bayer Childrens, Bufferin, Easprin, Ecotrin, Empirin, Genprin, Halfprin, Magnaprin, ZORprin | Aspirine |
| Butazolidin | Phenylbutazone |
| Cataflam, Voltaren | Diclofenac Systemic |
| DayPro | Oxaprozin |
| Dolobid | Diflunisal |
| Feldene, Novo-Pirocam, Nu-Pirox | Piroxicam |
| Indocin SR, Indocid, Novo-Methacin | Indomethacin |
| Lodine | Etodolac |
| Meclomen | Meclofenamate Sodium |
| Mobic | Meloxicam |
| Nalfon | Fenoprofen Calcium |
| Ponstan, Ponstel | Meclofenamic acid |
| Relafen | Nabumetone |
| Tolectin | Sodium ea Tolmetin |
Lisebelisoa:
Kefalakes H, TJ ea Stylianides, Amanakis G, Kolios G. "Ho eketseha ha maloetse a ho ruruha a amanang le tšebeliso ea lithethefatsi tse seng khahlanong le ho ruruha: tšōmo kapa nnete?" Eur J Clin Pharmacol . 2009 Oct; 65: 963-970.
Long MD, Kappelman MD, Martin CF, le al. "Karolo ea Likokoana-hloko tse khahlanong le ho ruruha ha li-anti-inflammatory" (Existerations of Inflammatory Bowel Disease). " J Clinic Gastroenterol . 2016 Feb; 50: 152-156.
Mahadevan U, Loftus EV Jr, Tremaine WJ, Sandborn WJ. "Tšireletseho ea Khetho ea Cyclooxygenase-2 Inhibitor ka Maloetse a Bohale a Tšoaetso." Am J Gastroenterol 2002 Apr; 97: 910-914.
Matuk R, Crawford J, Abreu MT, et al. "Bongata ba menoana ea chefo ea meno le phello ea lefu la ho etsa lintho tse khethollang cyclooxygenase-2 inhibitors ho bakuli ba tšoeroeng ke lefu la matšoafo." Inflam Bowel Dis 2004 Jul; 10: 352-356.
Ribaldone DG, Fagoonee S, Astegiano M, le al. "Tšireletseho ea Coxib ho bakuli ba nang le maloetse a bakoang ke ho ruruha ha maikutlo:" Ho hlahloba litlhaku. " Ngaka ea Makuli . 2015 Nov; 18: 599-607.
Sandborn WJ, Stenson WF, Brynskov J, et al. "Tšireletseho ea Celecoxib ho bakuli ba nang le lefu la ho qetela la ho phomola ha a le khopotsong: Thuto ea Pilot e sa fetoheng, e nang le sebaka se laoloang." Clin Gastroenterol Hepatol 2006 Feb; 4: 203-2011.
Singh S, Graff LA, Bernstein CN. "Na li-NSAID, Antibiotics, Infections, kapa Stress Trigger Flares ho IBD?" Am J Gastroenterol 2009; 104: 1298-1313; e hatisitsoeng ka la 31 March 2009.
Takeuchi K, Smale S, Premchand P, et al. "Ho ata le mekhoa ea phekolo ea meriana e sa sebeliseng lithethefatsi e sa thibeleng ho ruruha ho bakuli ba tšoeroeng ke mafu a ho ruruha." Clin Gastroenterol Hepatol . 2006 Feb; 4: 196-202.