Ho utloisisa Fibromyalgia le ME / CFS Lithethefatsi
Ha u ntse u ithuta ka likhetho tsa phekolo bakeng sa fibromyalgia le boloetse bo sa foleng ba mokhathala , mohlomong u tla fumana lentsoe "reuptake inhibitors." E hlalosa mofuta oa khatello ea kelello eo re atisang ho e fuoa, ho akarelletsa le meriana ea fibromyalgia e amohelehang ka FDA Cymbalta (duloxetine) le Savella (milnacipran) .
Empa na u utloisisa hore na reuptake e bolela'ng?
Ha u qala ho ithuta ka reuptake inhibitors, e ka ba e ferekanyang-re tseba maemo ana ho lumeloa hore a kenyeletsa maemo a tlase a lik'hemik'hale tsa boko serotonin le norepinephrine, kahoo ho nka ntho e thibelang ho utloahala e sa utloahaleng.
Tlhaloso ea sena e kenyelletsa mantsoe a mangata a bongaka ao boholo ba rona re ke keng ra a utloisisa. Ka tlase, o tla senyeha ha mokhoa ona ka puo eo ho leng bonolo ho e utloisisa.
Reuptake ke eng?
Ntlha ea pele, hanyane ka hanyane mabapi le hore na boko ba hao bo sebetsa joang:
Lisele tsa hao tsa boko (li-neurons) li arohane ka likheo tse nyane. Ha boko ba hao bo fetisa molaetsa ho tloha ho e mong ho ea ho e 'ngoe, e hula likheo tseo ka ho lokolla lik'hemik'hale tse khethehileng tse bitsoang li-neurotransmitters hore li nke molaetsa.
Ka mor'a nakoana, sebaka se pakeng tsa lisele li atisa ho ba le li-neurotransmitter tse ngata tse sebelisitsoeng. Ho tšoana le ho bula mangolo a hau le ho qetella ka qubu ea enfelopo e se nang letho-lifelopo tseo e ne e le tsa bohlokoa ho u romella mangolo, empa ha u sa li hloka.
Boko ba hau bo hloekisa bothata ka ho nchafatsa li-neurotransmitters e le hore li ka tsosolosoa hape. Mantsoe a bongaka bakeng sa seo ke reuptake.
Joale a re e nolofatse mme re tsamaee mohato o tsoelang pele:
Ak'u inahanele sekho se teteaneng ka morao setulong sa kamore ea ho jela. O batla ho fihla tafoleng, kahoo o hula sefahleho sa marang-rang ho pholletsa le sebaka.
Ha aa lokela ho ba le bothata ba ho ea moo a eang teng, empa mofuthu o tsitsitseng kahare ho kamoreng o ntse a fetola tataiso eo 'me a leleka web pele sekhopo se ka qeta leeto.
Joale, ak'u nahane hore motho e mong o fetola lebelo ka fensetere e le hore e sisinyehe butle haholoanyane. Seo se fa nako ea nakoana nako e lekaneng ea ho tšela lekhalo pele websaete e fofa.
Sekhopo ke molaetsa, web ke mokokotlo oa li-neurotransmitter, 'me fan e pheta-pheta hape. Ha o lieha ho tsuba, molaetsa o na le neurotransmitter e lekaneng ho fumana moo e eang teng. Reuptake inhibitors ha e ekelle kakaretso ea methapo ea kutlo ea bokooa bokong, empa e eketsa nako ea nako eo e fumanehang. E thusang melaetsa ho fumana moo ba eang teng.
Kamoo Reuptake e Etsanghalang Kateng ho Rōna
Bafuputsi ba bolela hore boko ba batho ba nang le fibromyalgia, boloetse bo sa foleng ba mokhathala le mafu a mang a mangata a kelello bo na le maemo a fokolang a li-neurotransmitter kapa ha ba sebelise li-neurotransmitters hantle. Seo se bitsoa neurotransmitter dysregulation, 'me ho lumeloa hore ke eona e ikarabellang ka matšoao a mangata a rona, ho akarelletsa le boko ba boko le ho matlafatsa bohloko .
Lipatlisiso li bontša hore ho lieha ho tsuba ho thusa ho fokotsa matšoao a batho ba bangata ba nang le maloetse ana.
Li-inhibitor tsa khale li ile tsa fokotsa ts'ebetso bakeng sa li -neurotransmitters tsohle , tse lebisang likotsing tse ngata tse sa batleheng. Mefuta ea kajeno ea reuptake inhibitors e khetholla batho ba khethehileng ba li-neurotransmitter-haholo-holo serotonin le eorepinephrine. Ba bitsoa:
- Selectional serotonin reuptake inhibitors (SSRIs)
- Serotonin-norepinephrine reuptake inhibitors (SNRIs)
Le hoja lithethefatsi tsena li baka mathata a seng makae ho feta meriana ea khale, li ntse li e-na le lethathamo le lelelele la litla-morao. Karolo e 'ngoe ea bothata ke hore ha re na bofokoli ba methapo ea mali sebakeng se seng le se seng sa boko, kahoo meriana e ka ntlafatsa phetisetso sebakeng se seng ha e ntse e e sitisa ho e' ngoe.
Leha ho le joalo, mofuta o mocha oa SSRI oa hlaha o ka fanang ka liphallelo ka liphello tse fokolang ka ho lebisa seleng ea boko e amohelang molaetsa oa neurotransmitter. Sele eo e bitsoa receptor, 'me mokelikeli ka mong o etselitsoe hore o fumane feela melaetsa e rometsoeng ke batho ba bang ba li-neurotransmitters. Ha e le hantle, mokamoli ke senotlolo. Ke tsona feela lik'hemik'hale tse nepahetseng tse ka li bulelang.
Lithethefatsi tsena tse ncha li sebelisa lisebelisoa tsa lik'hemik'hale tse ts'oanelang ho qhekella li-receptor tse itseng ho kena, ho nolofalletsa hore melaetsa e tsoele pele ho tloha seleng ho isa seleng. Bonyane lithethefatsi tse le 'ngoe tsa mofuta ona-Viibryd (vilazodone) -e amoheloa hona joale bakeng sa khatello ea maikutlo United States. (Leha ho le joalo, ha e e-s'o batlisisoe bakeng sa fibromyalgia kapa lefu le sa foleng la mokhathala.)
Ithute ho eketsehileng ka hore na lithethefatsi tsena li sebetsa joang maemong a rona:
Ho bona matšoao a amanang le ho haelloa ke methapo ea meriana, hammoho le dikgetho tsa phekolo, bala:
Lisebelisoa:
Masimo, R. Douglas, Ph.D. (2009) Boko bo bong. New York: Simon & Schuster.
Goldstein, J. Alasbimn Journal2 (7): April 2000. AJ07-5. "Pathophysiology le Treatment ea Chronic Chronic Fatigue Syndrome le Mathata a mang a Neurosomatic: Phekolo ea kelello Pilliseng."
Smith AK, le al. Psychoneuroendocrinology. 2008 Feb; 33 (2): 188-97. "Ho hlahlojoa ha liphatsa tsa lefutso tsa serotonergic tsamaiso ea boloetse bo sa foleng ba mokhathala."
Setsi sa Bongaka sa Univesithi ea 2008. Litokelo tsohle li sirelelitsoe. "Boloetse bo sa Feleng ba Boloetse"