Sheba Lits'ebetso tsa hau
Li-neurotransmitters tse 'maloa (manģosa a lik'hemik'hale bokong) li senyeha ka fibromyalgia (FMS) le lefu le sa foleng la mokhathala ( ME / CFS ). Ha u ntse u utloa ho eketsehileng ka serotonin le norepinephrine, ba bang ba 'maloa le bona ba ka senyeha hantle.
GABA le li-glutamate tse nang le li-neurotransmitters li bonahala eka li fokotsoe ka FMS le ME / CFS. Maemong a Glutamate kapa mosebetsi o bonahala eka o phahame, ha mahlakore a GABA kapa mosebetsi o bonahala o le tlaase.
Glutamate e susumetsa-'me e ka fetela-boko-bokong ba hao, ha GABA e e khutsisa. Ho se lekane ha bona ho ka ba le boikarabello, bonyane ka karolo e itseng, bakeng sa matšoenyeho a amanang le maemo ana hammoho le matšoao a mang. (Bakeng sa tse ling, bona GABA & Glutamate: Karolo ea 1 ).
Ho fetola mesebetsi ea li-neurotransmitters ho ka thusa ho fokotsa matšoao.
Lijo le Lisebelisoa bakeng sa Mosebetsi oa GABA / Glutamate
Lisebelisoa tsa ho fetola mosebetsi oa GABA le glutamate bokong ba hau ha lia ithutoa ka ho toba bakeng sa FMS le ME / CFS, empa re na le tsebo e akaretsang ka tsona.
Foromo ea maiketsetso ea GABA e fumaneha e le tlatsetso. Leha ho le joalo, maikutlo a hona joale a bongaka ke hore ha a tšele tšitiso ea mali-ea boko (BBB) kahoo ha a etse letho ho lokisa ho se leka-lekane ha methapo ea mali.
Ka ho makatsang, u ka khona ho eketsa tlhahiso ea GABA ka ho eketsa glutamate, kaha 'mele oa hau o sebelisa glutamate ho hlahisa GABA.
Ho eketsa tlhahiso ea glutamate, e ka thusa ho eketsa li-precursors tsa glutamate (lintho tseo 'mele oa hau o li sebelisang ho li etsa) ho lijo tsa hau kapa ho tlatsetsa.
Ba bang ba pele ho kenyelletsa:
- 5-HTP : 'Mele oa hau o fetola 5-HTP ho serotonin, mme serotonin e ka ntlafatsa mosebetsi oa GABA. 5-HTP ke mofuta oa maiketsetso oa tryptophan, o fumanoang ka Turkey. Leha ho le joalo, mehloli ea tryptophan ha e nahane hore e tšela BBB ka tsela eo 5-HTP e etsang.
- Glutamine: 'Mele oa hau o fetola amino acid ena ho glutamate. Glutamine e teng ka mokhoa oa tlatsetso 'me e teng nama, tlhapi, mahe, lebese, koro le meroho.
- Taurine: Ena ea amino acid e bontšitsoe ka litoeba ho fetola maemo a boko ba GABA le glutamate. U ka e nka ka foromo ea tlatsetso 'me ue fumane ka tlhaho linthong tsa nama le tsa tlhapi. Taurine e atisa ho eketsoa ho lino tse tahang.
- Theanine : Leqheka lena la glutamate le bonahala le fokotsa tšebetso ea glutamate bokong ka ho thibela li-receptors ha li ntse li matlafatsa maemong a GABA. E fumanoa ka tlhaho ka tee hape e fumaneha e le tlatsetso.
Ho ea ka phuputso ea 2011 ho na le probiotic e bitsoang Lactobacillus rhamnosus e ka fetolang mosebetsi oa GABA bokong ba hau. Bafuputsi ba re litoe tse jang baktheria li na le matšoenyeho a fokolang ha li behoa maemong a sithabetsang. Leha ho le joalo, sena se hloka lipatlisiso tse ngata pele e ka ba khothatso.
Pele u qala ho tlatsa lisebelisoa tse ncha kapa ho etsa liphetoho tsa bohlokoa tsa phepo, buisana le ngaka le setsebi sa metsoako ka likotsi tse ka bang teng le likamano tsa lithethefatsi . Bakeng sa tlhahisoleseling mabapi le ho qala li-supplement, bona: Lintho Tse 7 tseo U Lokelang ho li Tseba ka Lisebelisoa .
Lithethefatsi tse Etsang hore GABA le Glutamate ba sebetse ka bokooa
Meriana e 'maloa hona joale' marakeng e fetola mosebetsi oa boko oa GABA le glutamate.
Ba bangata ba 'nile ba lekoa le / kapa ba sebelisoa e le phekolo ea FMS, empa ho fokolloa ke ME / CFS.
Lithethefatsi tsena li bitsoa agonists. Ha li bakise mekhoa ea methapo ea methapo ea mafu empa ho e-na le hoo e eketsa ts'ebetso ka ho amohela li-receptors. Ha e le hantle, li etsa hore boko ba hau bo sebelise tse ling tse seng li le moo.
GABA agonists e kenyelletsa:
- Benzodiazepines: Lithethefatsi tsena li sithabetsa tsamaiso ea methapo ea bohareng. Li-benzodiazepines tse tloaelehileng li kenyelletsa Ativan (lorazepam), Klonopin (clonazepam), Valium (diazepam) le Xanax (alprazolam). Ka linako tse ling Benzodiazepines e ngotsoe bakeng sa FMS, haholo-holo ha ho hloka boroko le matšoenyeho li teng.
- Xyrem (oksibate ea sodium) & GHB (Gamma-Hydroxybutyric acid): Lithethefatsi tsena tse amanang haufi le tsona li sithabetsa tsamaiso ea methapo ea bohareng. Lebitso la seterateng la GHB ke " lithethefatsi tsa peto tsa letsatsi ." Xyrem e amoheloa bakeng sa matšoao a mang a ho khutla ha lefu, 'me lithuto li bontšitse hore li sebetsa hantle joaloka phekolo ea FMS; Leha ho le joalo, US Administration and Drug Administration Administration (FDA) e ile ae lahla bakeng sa FMS ka mathata a tšireletso.
- Non-Benzodiazepine Hypnotics: Sehlopha sena sa lithethefatsi se akarelletsa meriana e tloaelehileng ea ho robala Ambien (zolpidem), Sonata (zaleplon) le Lunesta (eszopiclone). Lithethefatsi tsena li fapane le lik'hemik'hale ho benzodiazepines empa li sebetsa ka ho tšoanang. Liphuputso tse ling (ho kenyeletsa Gronblad le Moldofsky, ka tlase) li bontšitse hore sehlopha sena sa lithethefatsi se ka ntlafatsa boroko 'me mohlomong se utloisa bohloko ho FMS. Ha ho le lithethefatsi tsena tse kileng tsa e-ba teng pele FDA e lumelloa.
Yoga e ka Eketsa GABA?
Hangata ho lumeloa hore Yoga e khutsisa. Na e hlile e ka eketsa GABA bokong? Thuto e 'ngoe e nyenyane e bontša hore e ka ba joalo. Bafuputsi ba tlalehile hore ho na le keketseho ea 27 lekholong ea likhahla tsa GABA tsa 'mele pele ho lingaka tse robeli.
Hona ke thuto e le 'ngoe feela, leha ho le joalo, re hloka lipatlisiso tse eketsehileng mabapi le hore na yoga e tsosa bokooa ba GABA le hore na e etsa joalo ho feta mesebetsi e tšoanang.
Neurotransmitter Dysregulation
Haeba o lumela hore o na le GABA / glutamate dysregulation, o lokela ho bua le ngaka ea hau mabapi le dikgetho tsa kalafo. Hopola hore esita le phekolo ea tlhaho e ka ba le litla-morao tse tebileng.
Ithute haholoanyane:
Lisebelisoa:
Bravo JA, le. al. Proceedings of the national academy of sciences ea United States of America. 2011 Sep 20; 108 (38): 16050-5. Ho kenngoa ha khatello ea Lactobacillus ho laola boitšoaro ba maikutlo le boikutlo bo bohareng ba GABA ea ho amohela molumo ka mouse ka mokhoa oa vagus.
Jacobs GE, le. al. Khatelo-pele ea neuro-psychpharmacology le lefu la kelello la likokoana-hloko. 2010 Apr 16; 34 (3): 486-91. Matšoao a li-glutamicate ka lebaka la ho susumetsa serotonergic.
Malemud CJ. Rheumatology ea meriana le liteko. 2009 Sep-Oct; 27 (Tlhaloso ea 56): S86-91. Tsepamisa maikutlo mekhoeng ea bohloko le pharmacotherapy ha ho phekoloa lefu la fibromyalgia.
Molchanova SM, Oja SS, Saransaari P. Ts'ebetso ea mokhatlo oa bophirimela oa litsekishene. 2007; 50: 95-7. Phello ea taurine ka tekano ea glutamate, GABA, glutamine le alanine ka rat ratatum le hippocampus.
Spitzer AR, Broadman M. Pein Practice. 2010 Jan-Feb; 10 (1): 54-9. Phekolo ea bothata ba ho robala ka narcoleptiform boemong bo sa foleng ba mokhathala le fibromyalgia e nang le oksibate ea sodium.