Ramatiki ea ramatiki , boloetse bo ikemetseng bo amang batho ba Amerika ba limilione tse 1,3 ho isa ho tse 1,5, ke phello ea lisele tsa 'mele tsa' mele tse hlaselang lefuba le manonyeletso. Ke eng e hlileng e eang haywire ho ' mele oa motho ea nang le ramatiki ea lefu la masapo ho baka bohloko le timetso tse amanang le lefu lena?
Liphuputso tse entsoeng ke Dr. Julia Ying Wang oa Brigham & Sepetlele sa Basali Boston le Harvard Medical School, hammoho le mosebetsi-'moho le eena Dr. Michael H.
Roehrl ea Harvard, li ile tsa hlahisoa sebokeng sa selemo le selemo sa American Chemical Society ka August 2002 'me sa hatisoa PNAS, sa sebetsana le potso ena.
Pele mosebetsi oa Wang le Roehrl o etsoa, lipatlisiso tsa ramatiki tsa lefu la masapo li ne li lebisitse haholo lipepeng, kapa likaroloana tsa protheine. Wang le Roehrl ba ile ba khothalletsa hore glycosaminoglycans, kapa GAG, ke sona se bakang ramatiki ea ramatiki ho e-na le liprotheine.
Theory GAGs
Li-glycosaminoglycans li na le lik'habohaedreite tse tsoang ka tlhaho tse fumanoang marapeng , liphatsa tse sebetsang , motsoako o kopantsoeng le letlalo. Glycosaminoglycans ke lik'habohaedreite tse rarahaneng. Ha ba amehe ke lik'habohaedreite, lichelete tse ngata le tsoekere tseo re li jang ha re ja.
Ka mantsoe a bonolo feela, khopolo ea Wang e ne e fana ka tlhahiso ea hore lisele tsa 'mele tsa immune, kapa li-antibodies, li lebise ho glycosaminoglycans. Li-antibodies li tlama ho GAG, li ipokelletse ka manonyeletso, 'me li baka bohloko le ho ruruha ho amanang le ramatiki ea lefu la rumatoid.
Lipatlisiso
Phuputsong ea Wang le Roehrl, litoeba li ne li kenngoa ka GAG.
Litoeba li ile tsa hlahisa lefu la ramatiki le sa foleng-joaloka matšoao, ho kopanyelletsa le ho ruruha, ho ruruha le ho fokola ha masapo.
Li-antibodies tsa Glycosaminoglycan li 'nile tsa fumanoa ka mahlahahlaha a bakuli ba ramatiki ba lefu la masapo. E lokela ho totobatsoa hore ena e ne e le lekhetlo la pele mafu a mang a glycosaminoglycan a ne a hlokomeloa ka liphoofolo kapa batho.
Bafuputsi ba hlokometse hore:
- GAG meriana e ka 'na ea hlaha ka lebaka la tšoaetso ea baktheria.
- Maemong a phahameng a GAG a ka hlahisa ha libaktheria li hlahisa lik'hemik'hale tse senyang lihlahisoa tse nang le li-connective le ho lokolla lik'habohaedreite.
- Libaktheria tse ngata li na le GAG seleng ea tsona. Matšoao a masapo a 'mele a ka itšireletsa ka phoso mahlaseli a' mele a hlahang ka 'mele ka tsela e tšoanang le eo a ka e lebisang ho GAG holim'a libetsa tsa baktheria.
Bafuputsi ba ne ba tšepile hore liphuputso tse ling li tla senola tsela ea ho tlama likokoana-hloko tsa GAG, e leng ho lebisang tlhokomelong ea meriana kapa meriana ea lefu la ramatiki. Phuputso e hatisitsoeng ka 2008, ho Arthritis Research & Therapy , e senoletse ho eketsehileng ka GAGS:
- Li-antibodies tse itseng tsa GAG ha li teng li-neonates (masea a sa tsoa tsoaloa).
- Li-GAG li teng ka chelete e ngata serum ea batho ba baholo.
- Li-GAG li arotsoe ka li-antigen tsa TI2. Lisele tsa B1 B li tsejoa hore li ikakhetse ka setotsoana le li-antigen tsa TI2.
E boetse e senotsoe hore lithibela-mafu tse khahlanong le GAG ke li-autoantibodies tsa tlhaho tse fumanehang ho batho ba phetseng hantle. Li-anti-GM tsa anti-GAG le tse ling tsa li-anti-GAG tsa mofuta oa IgG li ile tsa fumanoa li phahamisitsoe haholo ho sera ea bakuli ba nang le ramatiki ea lefuba. Le hoja li-anti-GAG li-antibodies li ne li le teng tsamaisong ea systemic, metsi a synovial a bile a khona ho tlama matrix ea extracellular ea lefu la hyaline.
Bafuputsi ba nahana hore tlhahiso ea anti-gag ea anti-GAG e "holimo-hloko" tabeng ea ramatiki ea lefu la rameum e ka 'na eaba e amana le ho lokolloa ha limolek'hule tsa lefuba. Ho thahasellisang ke hore litekanyo tse phahameng tsa ho loantša GAG li amahanngoa le ho se sebetse haholo ha lefu lena la ramatiki. Bafuputsi ba ile ba etsa qeto ea hore li-GAG li ka sebetsa e le likokoana-hloko tsa pele tsa mafu bakeng sa lefu la ramatiki.
Lisebelisoa:
Li-glycosaminoglycans li ka 'na tsa baka lebaka la ramatiki ea ramatiki. Proceedings of National Academy of Sciences ea United States of America. Wang JY le Roehrl MH. La 21 October, 2002.
Mefuta e mengata ea tlhaho ea likokoana-hloko e sebelisana le Glycosaminoglycans ka lefu la ramatiki. Bence Gyorgy et al. Pheputso ea ramatiki le Therapy. 2008.