Mokhathollo o Moholo oa Motsoako le lefu la tsoekere ke K'honthinente ea Pelo e Mpe
Bo-rasaense ba fumana bopaki ba hore lefu la tsoekere ka boeona le baka tšenyo ea k'holeseterole , e eketsa haholo monyetla oa ho hlaseloa ke pelo kapa stroke le ho feta. Likamano tse haufi pakeng tsa maemo ana a mabeli a kotsi li bolela hore haeba u na le lefu la tsoekere, u lokela ho falimeha haholo ka ho laola k'holeseterole ea hau.
Ho Kopanya Pakeng tsa Insulin le Cholesterol
Bafuputsi ba sa ntsane ba tseba hantle hore na lefu la tsoekere le fetola maemo a k'holeseterole joang maemong a lisele a nyenyane.
Baa tseba hore likarolo tse phahameng tsa insulin maling a atisa ho ama palo ea lik'holiseterole tse maling.
Mefuta e phahameng ea insulin e sebetsa ho phahamisa lenane la LDL-cholesterol ("k'holeseterole e mpe") e atisang ho etsa li-plaque li- arteries le ho fokotsa palo ea likarolo tsa cholesterol tsa HDL ("cholesterol e ntle") e thusang ho hlakola li-plaque tse kotsi pele li robeha ho tsoa ho baka lefu la pelo kapa stroke. Lefu la tsoekere le boetse le etsa hore ho be le mefuta e phahameng ea triglycerides , mofuta o mong oa mafura o potolohang maling.
Ka mokhoa o ts'oanang, k'holeseterole e phahameng e ka boela ea e-ba mohloli oa lefu la tsoekere; li-cholesterol tse phahameng li atisa ho bonoa ho batho ba nang le insulin ea ho hanyetsa, le pele ba e-ba le lefu la tsoekere le tletseng lefu. Ha maemo a LDL a qala ho hloa, litsebi li khothalletsa ho ela hloko ts'oaetso ea mali le ho qala ho ja le ho ikoetlisa ho thusa ho thibela lefu la tsoekere le lefu la pelo.
Sena ke sa bohlokoa haholo haeba u e-na le pale ea lelapa ea lefu la pelo.
Bakeng sa batho ba nang le lefu la tsoekere la Mofuta oa 1 , ho laola tsoekere ea mali ho ka etsa phapang e kholo. Ho laola tsoekere e ntle ea mali ho amana le maemo a tloaelehileng a k'holeseterole, a tšoanang le a batho ba se nang lefu la tsoekere. Empa batho ba nang le lefu la tsoekere la Mofuta oa 1 o laoloang hampe ba ekelitse litekanyetso tsa triglyceride le maemo a fokolang a HDL, a tlatsetsang ho nts'etsopele ea methapo ea moriana.
Mofuta oa 2 oa lefu la tsoekere: Tšoaetso e khethehileng ka ho khetheha e tsoang ho High Cholesterol
Batho ba nang le lefu la tsoekere la Mofuta oa 2 , ho sa tsotellehe taolo ea tsoekere ea mali, hangata ba eketsehile triglycerides , ba theohile HDL, 'me ka linako tse ling ba eketseha LDL. Tlhaloso ena ea k'holeseterole e ka 'na ea phehella le haeba tsoekere ea mali e laoloa ke mali - e supa boemong bo phahameng ka ho fetisisa ba ho hlahisa lipoleiti. Ha e le hantle, li-plaque tse entsoeng ka methapo ea batho ba nang le lefu la tsoekere ea Mofuta oa 2 hangata li mafura ebile li fokotseha haholo ho feta batho ba nang le lefu la tsoekere la Mofuta oa 1, e leng se lebisang kotsing e phahameng le ho feta ea sekhahla se senyehileng ho baka lefu la pelo kapa stroke.
Mokhatlo oa American Diabetes Association o khothalletsa hore ho hlahlojoe likarolo tsa k'holeseterole bonyane hanngoe ka selemo, kapa hangata ha li phahame mme li sa laoloe ke meriana. Bakeng sa batho ba nang le lefu la tsoekere le lefu le pelo le tsebahalang, ho kgothaletswa hore litefello tsa LDL maling e be ka tlase ho limiligrama tse 100 ka deciliter (mg / dL), hore litekanyetso tsa HDL li be ka holimo ho 50 mg / dL, 'me triglycerides e ka tlaase ho 150 mg / dL. Setekere e tšelisitsoeng ea mali, kapa tsoekere, tekanyo e ka tlaase ho 7% (<7%) tekong ea HA1C.
Bakeng sa batho ba nang le lefu la tsoekere le maloetse a lefu la pelo, ho akarelletsa le methapo e thibelitsoeng kapa ADA e khothalletsa LDL ka tlaase ho 70 mg / dL.
Ho finyella sepheo sena se tlaase haholo sa LDL ho ka 'na ha hloka meriana e phahameng ea meriana ea statin, empa e bontšoa ho fokotsa haholo kotsi ea lefu la pelo. Maemong a Triglyceride e lokela ho ba ka tlase ho 150 mg / dL le HDL ho feta 40 mg / dL. Basali ba nang le lefu la tsoekere le lefu la pelo la lefu la pelo ba khothalletsoa hore ba be le li-HDL tse phahameng ho feta 50 mg / dL.
Meriana e le 'ngoe, WelChol (colesevelam), e bontšitsoe ho fokotsa lebelo la tsoekere le k'holeseterole ho batho ba nang le lefu la tsoekere la Mofuta oa 2. Welchol e sebetsana ka ho thibela mala hore a amohele limolek'hule tse mafura lijong. Le hoja Welchol e theola litekanyetso tsa LDL , e ka hlahisa litekanyetso tsa triglyceride maling, 'me ha ea lokela ho sebelisoa ke batho ba nang le triglycerides e phahameng.
Metabolic Syndrome le Cholesterol
Batho ba nang le lihlopha tsa mathata a kang insulin ho hanyetsa, maemo a futsanehileng a k'holeseterole, khatello e phahameng ea mali le botenya ho hlalosoa e le lefu la metabolism (le tsejoang e le syndrome X). Liphuputso li fumane hore bakuli ba nang le HDL le ba phahameng triglycerides - matšoao a lefu la ts'oaetso - ba na le kotsi e kholo ka ho fetisisa ea ho hlokofatsoa ke lefu la pelo kapa stroke. Batho ba nang le phihlelo ena ea k'holeseterole ba boetse ba rua molemo haholo ho tsoa merianeng ea statin.
Likotsi tse fapa-fapaneng tsa lefu la pelo li hlaha ka letsoho 'me li lokela ho phekoloa hammoho. Batho ba nang le lefu la tsoekere - ba nang le kotsing e kholo ea letsatsi le letsatsi ba hlokofatsoang ke lefu la pelo - lokela ho ba hlokolosi haholo ka ho boloka tsoekere ea mali le k'holeseterole maemong a tlase. Hape ke habohlokoa ho boloka boima bo boima le khatello e tlaase ea mali le ho qoba ho tsuba.
Lisebelisoa:
Mokhatlo oa Amerika oa lefu la tsoekere. "ADA Tlhaloso ea Boemo: Mekhoa ea Tlhokomelo ea Bongaka ho Lefu la tsoekere." Tlhokomelo ea lefu la tsoekere 30 (2007): Tlatse 1.
McCulloch, David K. "Tlhaloso ea Tlhokomelo ea Bongaka ho Batho ba baholo ba nang le lefu la tsoekere Mellitus." UpToDate.com. 2008. UpToDate. 6 Apr 2008. (tlatsetso)
Meigs, James B. "Metabolism Syndrome (Insulin Resistance Syndrome kapa Syndrome X)." UpToDate.com. 2008. UpToDate. 7 Apr 2008. (ho ngolisa)
Nesto, Richard W. "Lintho tsa Bohlokoa le tsa Likotsi tsa Likooa tsa Pelo ea Coronary Diabetes Mellitus." UpToDate.com. 2008. UpToDate. 6 Apr 2008. (tlatsetso)
Pyorala, K., et al. "Ho fokotsa Liketsahalo tsa Ts'oaetso ea Simvastatin Metseng ea Nondiabetic Coronary Heart Mafu a Nang le Kantle ho Meriana ea Metabolic: Tlhahlobo ea Sehlopha sa Scandinavia Simvastatin Survival Study (4S)." Tlhokomelo ea lefu la tsoekere 27 (2004): 1735-40.
Rosenson, Robert S. "Tlhaloso ea Phekolo ea Hypercholesterolemia." UpToDate.com. 2008. UpToDate. 30 Mar2008 (ho ngolisa)
Rosenson, Robert S. "Lisosa Tse Ling tsa Dyslipidemia." UpToDate.com. 2008. UpToDate. 26 Apr 2008. (tlatsetso)
"Tlaleho ea Boraro ea Lenaneo la Thuto ea Cholesterol ea National (NCEP) Lekhahla la Bohlale la ho Tseba, ho Hlahloba le ho Phekola Haholo ea Mali ea Cholesterol ka Batho ba baholo (Tlhokomelo ea Batho ba baholo Bakeng sa Batho ba baholo)." Tsamaiso ea 106 (2002): 3143.
Zieve, FJ, MF Kalin, SL Schewartz, MR Jones, le WL Bailey. "Liphello tsa" Glucose-Tlhahiso e Fokolang ea WelChol Thuto (GLOWS): Thuto ea Pilot e laoloang ka nako e sa lekanyetsoang, e nang le bobeli, e nang le boipheliso Ho hlahloba phello ea Colesevelam Hydrochloride ho Laola Glycemic In Subjects le Mofuta oa 2 oa Lefu la tsoekere. " Clinical Therapeutics 29 (2007): 74-83.