Joalokaha saense ea bongaka e utloisisa haholoanyane ka lefu la fibromyalgia (FMS), lik'hamphani tsa meriana li qobella ho fumana FDA hore e amohele lithethefatsi tse ling tsa fibromyalgia. Lingaka li fana ka lithethefatsi tse amohelehang le meriana e mengata ea meriana e tlohang holimo hobane e fumane hore e atleha.
FDA-HLAHLISITSOA MOKHOA OA FIBROMYALGIA
Lyrica (pregabalin) : Ka June 2007, Lyrica e ile ea fetoha moriana oa pele oa FDA o amohelehang oa fibromyalgia.
Litekong tsa meriana , batho ba nang le FMS ba bontšitse ntlafatso e kholo ho bohloko, boroko, mokhathala le boleng ba bophelo . E entsoeng ke Pfizer, Lyrica e boetse e amoheloa bakeng sa ho phekola bohloko ba lefu la tsoekere la lefu la tsoekere le la neuralgia ea morao-rao . E boetse e sebelisoa, e kopantsoe le lithethefatsi tse ling, ho thibela ho ba le tšohanyetso-ho qala ho tšoaroa ke batho ba baholo ba lefu la sethoathoa.
E ka 'na ea bonahala eka e makatsang, empa Pfizer ha e tsebe hantle hore na ke hobane'ng ha Lyrica e sebetsa. Sena ke seo se se buang ka websaeteng ea FDA:
Mochine oa ketso o sa tsejoe, empa ho na le boitsebiso bo bong bo bontšang hore bo na le liphello ho lokolloa ha li-neurotransmitters bokong. Li-neurotransmitters ke lik'hemik'hale tse bokong tse fetisang lipontšo ho tloha ho neurone e 'ngoe ho ea ho e' ngoe.
Cymbalta (duloxetine) : The FDA e amohelehang Cymbalta e le lithethefatsi fibromyalgia ka June 2008. Cymbalta e khetholloa e le SNRI, kapa serotonin-norepinephrine reuptake inhibitor. Serotonin le norepinephrine ke li-neurotransmitter ka bobeli tse hlokang batho ba nang le fibromyalgia.
SNRIs li etsa hore li ngata li fumanehe bokong.
Cymbalta e ne e kile ea amoheloa ke FDA bakeng sa ho phekola ho tepella maikutlong le lefu la kelello la lefu la tsoekere .
Savella (milnacipran) : Ncha ea lithethefatsi 'marakeng oa US, Savella e ile ea amoheloa ka January 2009 e le lithethefatsi tsa fibromyalgia. E entsoe ke Forest Laboratories, Inc. le Cypress Bioscience, Inc., Savella ke motho ea nang le khatello ea kelello e tšoanang le ea Cymbalta ntle le hore ke eona lithethefatsi tsa pele ka tlelaseng ho matlafatsa norepinephrine ho feta serotonin.
Kopo ea Meriana e mecha ea lithethefatsi , e ileng ea kenngoa ka December 2007, e kenyelelitse lintlha tse tsoang litekong tse peli tsa Phase III tse amang bakuli ba fetang 2 000. Khamphani e re data e bontšitse Savella e ne e sebetsa haholo ho feta placebo mme e ne e mamelloa hantle. Ho ne ho se na lefu 'me bongata ba litla-morao bo hlalosoa e le bo bonolo ho isa boemong bo botle.
Milnacipran e rekisoa Europe ka mabitso a Dalcipran le Ixel. E 'nile ea rekisoa ka lilemo tse leshome' me e amoheloa ho tepella maikutlong linaheng tse fetang 50.
HO HLOKA HO HLAHALA HORE KE FIBROMYALGIA DRUGS
JZP-6 (oksibate ea sodium) : Liteko tsa meriana ea JZP-6 (sehlahisoa se sebetsang sa Xyrem) se bontšitse hore se ntlafalitse boleng ba boroko le ho fokotsa bohloko ba bakuli ba fibromyalgia . JZP-6 ke tsamaiso ea methapo ea pelo e tepeletseng 'me ho nahanoa hore e thusa mokuli hore a fihlele boemong bo tebileng ba mohato oa boraro le boemong ba 4 ba boroko. Tlhahlobo ea boithaopo ea Phase III e koetsoeng ka Sept. 2008 le Jazz Pharmaceuticals e romelitse Tlhahlobo e Ncha ea Drug ho FDA ka December 2009. Liphello tsa liteko tse ling tsa Phase III li ntse li emetse, empa khamphani e re liphuputso li tšehetse liphello tse ntle tse fetileng.
Xyrem ke FDA-e amohelehang bakeng sa ho lahleheloa ke matla (ho lahleheloa ke tšohanyetso ea mesifa) le ho robala ha letsatsi ka bongata ho bakuli ba nang le boloetse bo sa feleng.
Tlhokomeliso: Ka lebaka la matla a eona a ho hlekefetsoa, Xyrem ke sesebelisoa sa Kemiso III se laoloang ke mokhatlo.
Adeona Pharmaceuticals e tšepa ho fumana Effirma e amohelehang United States ka lekhetlo la pele, 'me ka April 2008 khamphani e phatlalalitse hore US FDA e fane ka Investigational New Drug Application. Sena se fana ka tumello ea ho tsamaisa liteko tsa kemiso ea likhallelo tsa Phase II tsa mahlakore a mabeli , tse peli , tse nang le bobeli , tse nang le bobeli bo nang le bokooa .
Mantsoe a molomo o amohelehile Europe ka lilemo tse fetang 25. Ha e le moo, e sebelisetsoa ho tšoara bohloko bo tsoang mehloling e 'maloa, ho akarelletsa le ho buuoa , kankere, lefu la seoa le sebete.
Leha ho le joalo, Adeona o na le tšepo ea ho bontša hore ha e sebetse feela bohloko ba FMS, empa e ntlafatsa maikutlo, khatello, mathata a ho utloisisa, ho sithabela ho robala le ho sebetsa ka kakaretso.
LINTHO TSE LING TSA FIBROMYALGIA
Ho imeloa kelellong : Likokoana-hloko li phahamisa lik'hemik'hale tse itseng bokong, ho kenyeletsa serotonin ea neurotransmitter le hormone ea khatello ea kelello norepinephrine - ka bobeli e tlaase ho batho ba nang le khatello ea kelello kapa FMS.
- Dual Reuptake Inhibitors: Sehlopha sena se kenyelletsa Cymbalta le Savella. Mehlala e meng ea lithethefatsi tsena ke: venlafaxine le nefazodone.
- Tricyclic Ho tepella maikutlo : Haeba ho nkoa bosiu, lithethefatsi tsena li ka thusa batho ba nang le FMS ho fumana boroko bo boleng bo botle. Ba boetse ba eketsa liphello tsa endorphin ea ho bolaea le ho thusa ho khatholla mesifa e bohloko . Li-tricyclic tse ling tse sebelisoang ho phekola FMS li kenyelletsa: amitriptyline, doxepin le nortriptyline.
- Selective Serotonin Reuptake Inhibitors ( SSRI s): Lithethefatsi tsena li fumana boko bo lokolla serotonin e mengata, e thusang ho laola boroko, 'me ka linako tse ling thusa batho ba nang le FMS hore ba ikutloe ba khathetse' me ba fumana khatello ho matšoao a mang. Leha ho le joalo, ba ka kena-kenana le boroko. Mehlala ea SSRIs ke: fluoxetine, paroxetine le sertraline.
Meriana eohle e thathamisitsoeng mona e na le litla-morao tse ka 'nang tsa baka mathata a tebileng a bongaka haeba u khaotsa ho ba tšoara ka tšohanyetso. Ho bohlokoa ho lula u buisana le ngaka ea hau ho buisana ka mathata leha e le afe kapa liphetoho tsa tekanyo.
BATHO / LITŠOANTŠO TSA LITŠOANTŠISO TSA FIBROMYALGIA
Liphuputso li bontša hore li-opiate ha li atlehe khahlanong le bohloko ba FMS. Leha ho le joalo, batho ba bangata ba tlaleha hore ba thusa, 'me lithethefatsi tsena li atisa ho behoa bakeng sa eona.
Li-opiates / li-narcotics li kenyelletsa:
- Vicodin (hydrocodone acetaminophen)
- Percocet (oxycodone acetaminophen)
- OxyContin (oxycodone)
Ho rarolla tšabo ea ho hlekefetsoa ha opiate le ho lemala, Mokhatlo oa American Pain o fane ka tataiso ho lingaka.
LINTHO TSE LING TSA LITŠOANTŠISO TSA LITŠOANTŠISO
- Etsa bonnete ba hore ngaka ea hau e tseba ka lithethefatsi tsohle le lisebelisuoa tse matlafatsang tseo u li nkang. Bua le ngaka kapa setsebi sa metsoako ka litla-morao 'me ho khoneha hore u sebelisane hantle.
- Ho bona lethathamo la litla-morao le likamano tsa lithethefatsi , hammoho le boitsebiso bo bong bo bongata, bona Drugs.com kapa RxList.com.
- Haeba u e-na le liphello tse mpe meriana, etsa bonnete ba hore u tla ba tlalehela ka Lenaneo la Tlaleho ea Tšireletso ea FDA ea Boitsebiso le Bobebe.
Mohloli:
NIH Publication NO. 04-5326.
US Administration of Drug and Drug Administration. "Ho Phela le Fibromyalgia"