Ke mesebetsi efe eo ba e etsang, ke mathata afe ao ba ka e bakang
GABA le glutamate ke li -neurotransmitters- baemeli ba tšebetso ba bokong ba hao. E mong o khutsisa, e 'ngoe e susumetsa,' me e tlameha ho lula e leka-lekana. Joale ho etsahala'ng haeba tekanyetso ee e lahleheloa?
Lipatlisiso tse ling li bontša hore ho se lekane ha lintho tsena tse peli ho ka ba le karolo ho fibromyalgia (FMS). Lipatlisiso ha lia tiea ha li kenella ho boloetse bo sa foleng ba mokhathala ( ME / CFS ), ka lipatlisiso tse ling li fetola bopaki ba ho senya maikutlo le ba bang ba sa fumane letho.
Boko ba Hao
Boko ba motho bo rarahane haholo. E mong le e mong oa neurotransmitter o etsa mesebetsi e fapa-fapaneng, 'me a sebelisana le li-neurons tsa hao (lisele tsa bokopi) ka mokhoa o rarahaneng oo re sa o utloisiseng ka botlalo.
Leha ho le joalo, re ntse re ithuta ho eketsehileng ka boko le bafuputsi ba khonne ho hokahanya tse ling tse sa tloaelehang tsa mafu a matšoao ho mafu a itseng kapa matšoao. Ba boetse ba fumane litsela tsa ho fetola mosebetsi oa li-neurotransmitter mme ba ka bona liphello tsa sebele tseo li nang le tsona litabeng tsa patlisiso.
Boko ke mokhoa o tsitsitseng oa ho pheta-pheta, hangata o sebelisa mothapo o mong oa li-neurotransmitter ho theha e 'ngoe. Mosebetsi ona o etsa hore o be le kutloisiso e kholo ha u ntse u bua ka li-neurotransmitters tse nang le mesebetsi e fapaneng, e kang GABA le glutamate. Serotonin e tsejoang hantle le bobeli ba melatonin ke mohlala o mong, joalo ka norepinephrine le dopamine. Ho lumeloa hore li-neurotransmitters kaofela li fokotsoa ka maemo ana.
Ha e mong oa methapo ea meriana e sa sebetse hantle, e ka 'na ea etsa hore e mong a se ke a leka-lekana.
Glutamate
Glutamate ke mofuta oa cheerleader ea boko ba hao. E 'ngoe ea mesebetsi ea eona e ka sehloohong ke hore lisele tse ling tsa boko li hlaseloe. E ba susumelletsa hore ba khone ho etsa lintho tsa bohlokoa tse kang ho ithuta tlhahisoleseding e ncha kapa ho hopola lintho-lintho tse ling tseo glutamate e amehang ho tsona.
Leha ho le joalo, moshanyana ea sa khaotseng ho etsa hore u hlahise lintho o halefa ka nakoana. Ho hongata haholo ho susumetsang hase ntho e ntle, kaha mang kapa mang ea tahiloeng ka tsela e ngata haholo kofi a ka u bolella. Maemong a mang, glutamate e ka fetoha seo ho thoeng ke "excitotoxin," e bolelang hore ka linako tse ling e bonahala eka ke ho feta-ho thabisa li-neurone ho fihlela ba ipolaea.
Bokhoni ba ho baka lefu la lisele tsa boko ke hore na ke hobane'ng ha glutamate e lumeloa hore e ameha ho maloetse a mang a ho holofala a kang a Alzheimer's disease le amyotrophic lateral sclerosis (ALS kapa lefu la Lou Gehrig). (Hlokomela: FMS le ME / CFS ha li lumele e mpefatse.)
Ho FMS, lipatlisiso li bontša maemo a phahameng ka ho sa tloaelehang a glutamate karolong e itseng ea boko e bitsoang insula kapa insular cortex. Bafuputsi ba ile ba ea holimo hobane sebaka seo se ameha haholo mahlomoleng le maikutlong, e leng lintho tse ka sehloohong tsa boemo boo. Sebaka sena sa insula se boetse se ameha ka kutloisiso ea kutlo, boiphihlelo ba likoloi, matšoenyeho, mathata a ho ja le ho lemala.
Liphuputso li boetse li amahanngoa le maemo a phahameng a glutamate a nang le ho tepella maikutlong le ts'ebetso e tlaase ea tsebo ho batho ba nang le lefu la tsoekere la mofuta oa 1. (Glutamate e ka fumanoa ho tsoekere, e atisang ho ba le lihlopha tsa lefu la tsoekere.) Bonyane phuputso e le 'ngoe ea FMS e bontšitse hore ho theola mahlakore a glutamate ho ka fokotsa bohloko.
Ho ba le boko bo feteletseng bokoetliso ho lumeloa hore bo baka matšoao a mangata, ho akarelletsa:
- hyperalgesia (bohloko bo matlafatsang, karolo ea bohlokoa ea FMS)
- ho tšoenyeha
- ho se phomole
- Matšoao a kang a ADHD, a kang ho sitoa ho tsepamisa maikutlo
Ka ME / CFS, bafuputsi ba bang ba etsa qeto ea hore mosebetsi oa glutamate o tlase, o bolelang hore boko ha bo fumane ts'ebetso e lekaneng. Leha ho le joalo, tumelo ena ha e e-s'o tšehetsoe ke bopaki.
Ho lumeloa hore ho haelloa ke glutamate bokong ho baka matšoao ho akarelletsa:
- ho hlobaela
- mathata a mahloriso
- ho khathala kelellong
- matla a fokolang
GABA
GABA emela gamma-amino-n-butyric acid. Boko ba hau bo sebelisa glutamate ho hlahisa GABA.
Mosebetsi oa mantlha oa GABA ke ho kokobetsa boko ba hao.
E boetse e ameha ho robala, boikhathollo, molao oa khatello le mesifa ea mosebetsi.
GABA e lumeloa e le e tlase kapa e sebelisoa hampe FMS. Ho fihlela joale, lipatlisiso ha li fane ka maikutlo a GABA dysregulation ka ME / CFS.
Ka lebaka la GABA le kamano ea kamano e haufi le matšoao, matšoao a bokooa a GABA a ka tšoana, kapa a kopana le, a boko ba glutamate bo feteletseng.
Ho Fumana Tekanyo
Haeba u belaella GABA / glutamate dysregulation e baka matšoao a mang, bua le ngaka ea hau ka eona. Ho na le lithethefatsi, li-supplement, le liphetoho tsa lijo tse ka u thusang ho fumana tekanyo e nepahetseng. O ka hlahloba dikgetho tseo mona:
Lisebelisoa:
Hannestad U, Theodorsson E, Evengård B. Koranta ea Machaba ea litsebi tsa bongaka. 2007 Feb; 376 (1-2): 23-9. Epub 2006 Jul 14. beta-Alanine le gamma-aminobutyric acid ka lebaka la boloetse bo sa feleng ba mokhathala.
Harris RE, et. al. Ramatiki le rheumatism. 2009 Oct; 60 (10): 3146-52. Litho tse phahameng tsa glutamate tsa fibromyalgia li amahanngoa le bohloko ba liteko.
Harris RE, et. al. Ramatiki le rheumatism. 2008 Mar; 58 (3): 903-7. Mefuta e matla ea glutamate ka har'a insula e amahanngoa le ntlafatso ea libaka tse ngata tsa bohloko ho fibromyalgia.
> Lyoo IK, le. al. Litlaleho tsa mafu a kelello ka kakaretso. 2009 Aug; 66 (8): 878-87. Litekanyetso tsa li-prefutal glutamate-glutamine-gamma-aminobutyric acid le likamano tse fokolang tsa ts'oaetso le matšoao a tepeletseng a mofuta oa lefu la tsoekere la mofuta oa 1.
Murrough JW, le. al. NMR ho biomedicine. 2010 Jul; 23 (6): 643-50. Lactate e eketsehileng ea ventricular e nang le boloetse bo sa foleng ba mokhathala o lekantsoeng ke litšoantšo tsa 1H tsa MRS ka 3.0 T. II: ho bapisoa le lefu le tebileng la ho tepella maikutlo.