Glutamate ke eng?
Tlhaloso:
Glutamate ke mofuta oa lik'hemik'hale tsa boko tse bitsoang neurotransmitter , e bolelang hore e thusa ho fetisa melaetsa e pota-potileng boko. Hangata ho ameha ho ithuta le ho hopola. Glutamate e boetse e ameha maloetseng a mangata a likokoana-hloko.
E boetse e tsejoa e le: L-glutamic acid, glutamic acid, L-glutamate
Hangata ba ferekane le: Glutamine
Glutamate e etsa mesebetsi e meng ea bohlokoa bokong ba hau.
Ho nkoa e le mothapo oa ho ba le pelo ea ho ithabisa, e bolelang hore o susumetsa libaka tsa boko kapa likarolo tse ling tsa tsamaiso ea methapo. Mofuthu oa mofuta ona ke karolo ea bohlokoa ea ho ithuta, kahoo ka tsela eo, glutamate ke ntho e ntle.
Leha ho le joalo, boholo ba glutamate hase hakaalo seo u se batlang. Maemong a mang, e ka fetoha seo ho thoeng ke excitotoxin. "Toxin" ke seoelo e leng lentsoe le letle, 'me ka sebele ha le nahane tabeng ena. Karolong ea eona e le excitotoxin, glutamate e ka fetelletsa lisele tsa hau tsa boko.
Haeba maemo a phahameng a sa hlahlojoe, motsoako ona oa methapo ea matla a ka fetela lisele tseo ho fihlela a nka bohato bo matla 'me a etsa boitlamo ba li-cellular e le hore a sireletse lisele tse li potolohileng. (Ak'u nahane joalo ka ho ntša leino le bolileng e le hore ho senyeha ho se ke ha hasana meno a haufi le eona.)
Lisele tsa 'meleng oa rona li shoa ka nako eohle,' me boholo ba tsona li ka nkeloa sebaka. Leha ho le joalo, li-glutamate tse khanna ho ipolaea, ke li-neurons.
Boko ba hau bo ke ke ba etsa hore ba ncha ba nkeloe sebaka, kahoo ke habohlokoa ho ba boloka ba phetse hantle 'me ba sireletsehile.
Karolo ea Glutamate e le excitotoxin ho lumeloa hore e ameha ka mathata a sa tšoaneng a methapo ea mafu a kang multiple sclerosis, lefu la Alzheimer's le amyotrophic lateral sclerosis (tse tsejoang e le ALS kapa lefu la Lou Gherig).
Glutamate dysregulation e boetse e nkoa e le karolo ea fibromyalgia le boloetse bo sa foleng ba mokhathala , le hoja maemo ana a sa nkoa e le neurodegenerative.
Glutamate & Fibromyalgia
Lipatlisiso li bontša hore batho ba nang le fibromyalgia ba na le litekanyo tse sa tloaelehang tsa glutamate sebakeng sa boko se bitsoang insula kapa li-cortex. Sebaka sena sa insula se ameha haholo tabeng ea ho sebetsana le bohloko le maikutlo a mabeli. Litekanyetso tse phahameng tsa glutamate ke pontšo ea hore sebaka sena sa boko se ka 'na sa fetoloa haholo ka boemo bona.
Lihlekehleke tsena li boetse li kenyeletsa ho:
- lisele
- ho tšoenyeha
- tsebo ea likoloi
- litakatso
- mathata a ho ja
- lemalla
Ka fibromyalgia, tlhahiso ea maikutlo e ka 'na ea eketseha, e lebisang ho feteletseng . Ho t soenyeha ke letšoao le tloaelehileng / boemo bo qaqileng. Tsebo ea likoloi e ka 'na ea e-ba ea senyeha, e lebisang ho leka-lekanya mathata le ho oa . Mathata a ho ja a ka 'na a tloaeleha ho batho ba nang le fibromyalgia, hape.
Glutamate e teng libakeng tsa 'mele ntle le tsamaiso ea methapo, moo e sebetsang joaloka hormone. Karolong ena, e ka baka bohloko.
Phuputso ea 2016 e bontša hore boikoetliso bo ka fokotsa bohloko bo amanang le glutamate ho batho ba nang le fibromyalgia, e ka thusang ho hlalosa kamano e sa utloisiseng pakeng tsa boemo bona le boiteko .
Glutamate ho Syndrome ea Mokhathala o sa Feleng
Liphuputso li arotsoe ka hore na glutamate dysregulation e phetha karolo ea ho kula mokhathala o sa feleng, boemo boo hape bo akarelletsang mathata a ho imeloa kelellong, matšoenyeho le mathata a ho tsamaea / ho leka-lekanya .
Leha ho le joalo, ho fapana le fibromyalgia, liphuputso li bontša hore litekanyo tsa glutamate li ka 'na tsa e-ba tlase libakeng tse ling tsa boko. Seo se utloahala ha u nahana ka boko ba boko bo amanang le lefu lena, le akarelletsang mathata a ho ithuta.
Hape re na le bopaki bo bong bo bontšang hore mokhathala o sa foleng oa mokhathala o ka 'na oa akarelletsa liphatsa tsa lefutso tse amanang le glutamate dysregulation.
Monosodium Glutamate
Joaloka amino acid, glutamate ke motsoako oa monosodium glutamate (MSG), e sebelisoang meriana e meng le ho eketsa lijo.
E ka 'na ea amana le liphello tse mpe tsa bophelo bo botle.
Litsebi tse ling tsa tlhokomelo ea bophelo bo botle li lumela hore li-MSG li ka ba kotsi ho batho ba nang le fibromyalgia, ha ba bang ba lumela hore ha ho joalo. Batho ba bang ba bolela hore ho tlosa MSG lijong tsa bona ho thusitse ho fokotsa matšoao a fibromyalgia le boloetse bo sa foleng ba mokhathala, empa litlaleho tsena ha li tiisetsoe ke saense ea bongaka.
Li-glutamate le li-neurotransmitters tse ling
U ka 'na ua ipotsa hore na boko ba hao bo sebetsana joang le maemo a phahameng a glutamate. E na le tharollo-e 'ngoe ea li-neurotransmitter e bitsoang GABA. Mosebetsi oa GABA ke ho khutsisa boko ka mor'a hore glutamate e phutholohe.
Ke habohlokoa hore GABA le litekanyetso tsa glutamate li lekane , empa hangata ha ho joalo ka boloetse bo amanang le glutamate.
Litsebi tse ling tsa meriana tse amanang le maemo ana li kenyelletsa:
Hannestad U, Theodorsson E, Evengård B. Koranta ea Machaba ea litsebi tsa bongaka. 2007 Feb; 376 (1-2): 23-9. beta-Alanine le gamma-aminobutyric acid ka boloetse bo sa feleng ba mokhathala.
Harris RE, et. al. Ramatiki le rheumatism. 2009 Oct; 60 (10): 3146-52. Litho tse phahameng tsa glutamate tsa fibromyalgia li amahanngoa le bohloko ba liteko.
Kuratsune H, Yamaguti K, Lindh G, et al. NeuroImage. > 2002 Nov; 17 (3): 1256-65. Libaka tse nang le bokooa tse amanang le mokhathala o utloahalang: ho fokolloa ke acetylcarnitine bokong.
> Martins DF, Setenete A, Ludtke DD, et al. Li-molecular neurobiology. 2016 Sep. 13. [Epub pele ho khatiso] Boima bo matla ba ho sesa bo fokotsa ho nociception e bakoang ke glutamate ka ho sebelisoa ha li-protein-coupled receptors tse thibelang phosphorylated protein kinase a.
Smith AK, Fang H, Whistler T, le al. Neuropsychobiology. > 2011; 64 (4): 183-94. Liphuputso tsa genomic tsa convergent li khetholla mokhatlo oa GRIK2 le NPAS2 o nang le boloetse bo sa feleng ba mokhathala.