Sebaka sa 'mala o mosehla se entsoeng ke lifate tsa mukul myrrh ( Commiphora mukul ), guggul e' nile ea sebelisoa ka lilemo tse likete ka ayurveda (meriana ea setso ea India). Basebetsi ba meriana ea ayurvedic ba atisa ho kopanya lisebelisoa tsa guggul le lisebelisoa tse ling tsa tlhaho ho folisa mathata a bophelo bo kang mafu a masapo, manonyeletso le mafu a moriana. Guggul e boetse e nkoa e le pheko bakeng sa mafura, hammoho le ho lahleheloa ke boima ba 'mele.
Melemo ea Bophelo ea Guggul
Ho fihlela joale, ts'ehetso ea saense bakeng sa melemo ea guggul e haella.
1) Cholesterol e phahameng
Le hoja guggul e sebelisoa haholo India ho loantša k'holeseterole e phahameng, lipatlisiso tsa liphello tsa ho tlohela k'holeseterole e hlahisitsoeng ke liphello tse tsoakaneng. Phuputso ea 2009 ea batho ba baholo ba 43 ba nang le k'holeseterole e phahameng ka mokhoa o itekanetseng, ka mohlala, ba fumane hore ba ileng ba nka 2,160 mg ea guggul ka foromo ea capsule letsatsi le leng le le leng ba ne ba e-na le palo e kholo ea k'holeseterole ho feta ba ileng ba nka pilisi ea placebo. Leha ho le joalo, litho tsa thuto tse ileng tsa sebelisa guggul ha li bontše ho fokotseha ho hoholo lihlopheng tsa bona tsa LDL ("bad") k'holeseterole.
Phuputso e 'ngoe e phatlalalitsoeng ka 2003, e fane ka batho ba baholo ba 103 ba nang le k'holeseterole e phahameng ho nka 1000 mg kapa 2,000 mg ea guggul letsatsi le leng le le leng ka libeke tse robeli' me ba fumane hore karolo e nkiloeng e hlahisitse li-LDL k'holeseterole.
Ho feta: litlhare tsa tlhaho ho theola k'holeseterole .
2) Ho lla
Liphuputso tsa pele li bontša hore lesela la guggul le ka thusa ho loantša lisele.
Phuputso e 'ngoe ea 2007 ka lisele tsa batho e fumane hore guggulsterone (e leng motsoako o fumanoang ka guggul) e bakile lefu la lisele tsa kankere ea senya, ha tlaleho ea 2008 e bontša hore guggulsterone e sititse ho hōla ha lisele tsa letlalo ka litoeba.
3) Osteoarthritis
Phuputso e 'ngoe e bontša hore lesela la guggul le ka thusa ho fokotsa matšoao a lefu la osteoarthritis la lengole.
Ithute ka litlhare tsa tlhaho tsa lefu la masapo a osteoarthritis .
Lithako
Sehlahisoa sa Guggul se ka 'na sa baka litla-morao tse kang hlooho, ho nyeheloa ke pelo, le ho halefa ha letlalo (hangata e le mofuta oa ho phatloha) ho batho ba bang. Kaha guggul e fumanoe e le ho susumetsa qoqotho, motho ea nang le boemo ba qoqotho o lokela ho ea ngakeng pele a sebelisa pokello ea guggul.
Phuputsong ea 2004, bo-rasaense ba fumane hore guggulsterone e ka thibela liketso tsa lithethefatsi tse fokolisitsoeng ke lik'hemik'hale tsa CYP3A tsa 'mele. Lithethefatsi tsena li kenyelletsa Lipitor, cyclosporine, le quinidine.
Lisebelisoa ha li e-s'o hlahlojoe polokeho 'me ka lebaka la hore lijo tse ling tsa lijo tse ngata li sa tsamaisoe ka molao, lihlahisoa tsa lihlahisoa tse ling li ka fapana le se hlalositsoeng holim'a lihlahisoa tsa sehlahisoa. Hape hopola hore polokeho ea liphallelo ho basali ba nang le bakhachane, bo-'mè ba tlhokomelo, bana le ba nang le maemo a bophelo kapa ba noang meriana ha e e-s'o thehoe. U ka fumana litlhahiso tsa ho sebelisa lisebelisoa tse ling mona , empa haeba u nahana ka tšebeliso ea guggul, buisana le mofani oa hao oa tlhokomelo ea mantlha pele. Ho itšoara ka boithati le ho qoba kapa ho lieha tlhokomelo e tloaelehileng ho ka ba le liphello tse tebileng.
> Mehloli:
> Brobst DE, Ding X, Creech KL, Goodwin B, Kelley B, Staudinger JL. "Guggulsterone e Sebelisa Batho ba bangata ba Nuclear Receptors Reporors le Likotsi cyp3a Gene Ho Boleloa ka ho Pregnane X Receptor." Journal ea Pharmacology le Experimental Therapeutics 2004 310 (2): 528-35.
> Nohr LA, Rasmussen LB, Straand J. "Resin e tsoang Sefate sa Myrrh ea Mukul, Guggul, Na e ka Sebelisoa ho Phekola Hypercholesterolemia? Thuto e Laoloang, e Laolang." Litlhare Tse Phelisang ka Meriana 2009 Jan; 17 (1): 16-22 .
> Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Mukhtar H. "Guggulsterone Modulates MAPK le NF-kappaB 'Me e Thibela Letlalo la Tumorigenesis Meleng ea SENCAR." Carcinogenesis 2008 29 (10): 2011-8.
> Singh BB, Mishra LC, Vinjamury SP, Aquilina N, Singh VJ, Shepard N. "Katleho ea Mukuphora ea Mukul bakeng sa Osteoarthritis ea Knee: > e > thuto ea Lipatlisiso." Mekhoa e meng ea phekolo ea Bophelo le Meriana 2003 9 (3): 74-9.
> Singh SV, Choi S, Zeng Y, Hahm ER, Xiao D. "Guggulsterone-E entsoe ka Apoptosis Mananeng a Kankere ea Batho ba Ts'oaetso ea Lefatše e Bakiloe ke Tšebeliso ea Oxygen Bohareng ba Ts'ebetso e Ncha ea c-Jun NH2-Terminal Kinase." Phuputso ea kankere 2007 1; 67 (15): 7439-49.
> Szapary PO, Wolfe ML, Bloedon LT, Cucchiara AJ, DerMarderosian AH, Cirigliano MD, Rader DJ. "Guggulipid bakeng sa Phekolo ea Hypercholesterolemia: Tlhahlobo e laoloang ka nako e sa lekanyetsoang." JAMA 13; 290 (6): 765-72.